On 2016 Feb 22, Daniel Corcos commented:

Actually, it is possible to estimate the relative risk associated to mammography by comparing the incidence of cancer in women with no exposure (whose age differ from women with exposure) to that of a BRCA carrier recent birth cohort (born after 1958) in figure 3 of Gabai-Kapara et al. It is also possible to use the data on interval breast cancer after negative mammography, showing that BC incidence is divided by more than three within two years following negative mammography (Bucchi et al., 2008). Both results suggest that figure 1 and 2 of Giannakeas et al. indicate a doubling of cancer incidence as a consequence of mammography. In other terms, these results suggest that a woman carrying a BRCA1 or BRCA2 mutation has a reasonable chance of not developing cancer if she has no mammography, and a very small chance to be spared if she has repeated mammography screening.

References

Gabai-Kapara et al; http://www.ncbi.nlm.nih.gov/pubmed/25192939

Bucchi et al. http://www.ncbi.nlm.nih.gov/pubmed/18416953

On 2016 Feb 08, Daniel Corcos commented:

Whether mammography screening increases the risk of breast cancer in women with DNA repair defect is an important question. In this paper, Giannakeas et al. found no difference in cancer incidence in women with previous mammography screening as compared to women with no prior irradiation. Negative mammography identify a population with a lower risk, since women with breast cancer are not part of the study. In the case of colon cancer, people with previous negative colonoscopy have a strongly reduced risk as compared to people with no previous colonoscopy (Brenner et al., 2011). Similarly it would be expected that women with negative mammography have a lower cancer incidence as compared to women with no previous mammography. Thus, Giannakeas et al. result suggests that mammography increases the risk of developing breast cancer in mutation carriers. http://www.ncbi.nlm.nih.gov/pubmed/21876077

On 2016 Feb 08, Daniel Corcos commented:

Whether mammography screening increases the risk of breast cancer in women with DNA repair defect is an important question. In this paper, Giannakeas et al. found no difference in cancer incidence in women with previous mammography screening as compared to women with no prior irradiation. Negative mammography identify a population with a lower risk, since women with breast cancer are not part of the study. In the case of colon cancer, people with previous negative colonoscopy have a strongly reduced risk as compared to people with no previous colonoscopy (Brenner et al., 2011). Similarly it would be expected that women with negative mammography have a lower cancer incidence as compared to women with no previous mammography. Thus, Giannakeas et al. result suggests that mammography increases the risk of developing breast cancer in mutation carriers. http://www.ncbi.nlm.nih.gov/pubmed/21876077

On 2016 Feb 22, Daniel Corcos commented:

Actually, it is possible to estimate the relative risk associated to mammography by comparing the incidence of cancer in women with no exposure (whose age differ from women with exposure) to that of a BRCA carrier recent birth cohort (born after 1958) in figure 3 of Gabai-Kapara et al. It is also possible to use the data on interval breast cancer after negative mammography, showing that BC incidence is divided by more than three within two years following negative mammography (Bucchi et al., 2008). Both results suggest that figure 1 and 2 of Giannakeas et al. indicate a doubling of cancer incidence as a consequence of mammography. In other terms, these results suggest that a woman carrying a BRCA1 or BRCA2 mutation has a reasonable chance of not developing cancer if she has no mammography, and a very small chance to be spared if she has repeated mammography screening.

References

Gabai-Kapara et al; http://www.ncbi.nlm.nih.gov/pubmed/25192939

Bucchi et al. http://www.ncbi.nlm.nih.gov/pubmed/18416953