On 2017 Nov 12, Gerardo Ferbeyre commented:

I have red this paper many times and I find always inspiration for experiments and new ideas. The authors condensed a tremendous body of work while keeping their main message beautiful and simple. In pancreatic cancer, inhibition of the RAS/MAPK pathway allows the emergence of a subpopulation of dormant tumor stem cell with increased dependency on mitochondria. We have reproduced many of the key characteristics of these pancreatic cancer stem cells using a different experimental model and I wonder whether this phenotype is unique to these cancer cells when they evolve or whether the cells are reactivating a primitive embryonic program of pancreatic epithelial stem cells.

On 2017 Nov 12, Gerardo Ferbeyre commented:

I have red this paper many times and I find always inspiration for experiments and new ideas. The authors condensed a tremendous body of work while keeping their main message beautiful and simple. In pancreatic cancer, inhibition of the RAS/MAPK pathway allows the emergence of a subpopulation of dormant tumor stem cell with increased dependency on mitochondria. We have reproduced many of the key characteristics of these pancreatic cancer stem cells using a different experimental model and I wonder whether this phenotype is unique to these cancer cells when they evolve or whether the cells are reactivating a primitive embryonic program of pancreatic epithelial stem cells.