On 2014 Sep 10, Suleyman Serdar Koca commented:

I thank the comment first of all. The evaluation of serum IL-33 levels was not the primary aim of the present study. It was analyzed in limited patients to determine whether IL-33 gene polymorphisms affect serum IL-33 level. However, the detected relations of serum IL-33 level with the clinical signs were reported. Behçet’s disease has complex ethiopathogenesis. Genetic basis of the disease is divergent. Not only patients with different ethnic origins but also each patient has different disease burden. Therefore, the results of cytokines may be divergent in the different cohort.

On 2014 Aug 26, Kamel Hamzaoui commented:

Recently an interesting paper was published in Brain Behv Immunology about IL-33 in the CNS

On 2014 Aug 26, Kamel Hamzaoui commented:

Interesting paper. I cannot understand how the authors found similar IL-33 levels in BD patients than in healthy controls (52 patients were studied). They also found increased levels of IL-33 in BD patients with uveitid (32 patients were studied). We found the same increase of IL-33 in BD patients with retinal uveitis. We and others found increased levels of IL-33 in serun, in cerebrospinal fluid and in EN skin lesions measured at the mRNA and immunohistology.

Our laboratory and the Korean laboratory used the same Kit Elisa, but not the authors. The authors of the paper have to study control disease such as RA, SLE, MS patients.

Thank you

On 2014 Aug 26, Kamel Hamzaoui commented:

Interesting paper. I cannot understand how the authors found similar IL-33 levels in BD patients than in healthy controls (52 patients were studied). They also found increased levels of IL-33 in BD patients with uveitid (32 patients were studied). We found the same increase of IL-33 in BD patients with retinal uveitis. We and others found increased levels of IL-33 in serun, in cerebrospinal fluid and in EN skin lesions measured at the mRNA and immunohistology.

Our laboratory and the Korean laboratory used the same Kit Elisa, but not the authors. The authors of the paper have to study control disease such as RA, SLE, MS patients.

Thank you

On 2014 Aug 26, Kamel Hamzaoui commented:

Recently an interesting paper was published in Brain Behv Immunology about IL-33 in the CNS

On 2014 Sep 10, Suleyman Serdar Koca commented:

I thank the comment first of all. The evaluation of serum IL-33 levels was not the primary aim of the present study. It was analyzed in limited patients to determine whether IL-33 gene polymorphisms affect serum IL-33 level. However, the detected relations of serum IL-33 level with the clinical signs were reported. Behçet’s disease has complex ethiopathogenesis. Genetic basis of the disease is divergent. Not only patients with different ethnic origins but also each patient has different disease burden. Therefore, the results of cytokines may be divergent in the different cohort.