- Jul 2018
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europepmc.org europepmc.org
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On 2014 Sep 01, Amanda Capes-Davis commented:
The authors describe KB as an epidermoid cell line. Although this term is widely used, it is not accurate for this cell line. KB is known to be cross-contaminated with HeLa and thus is a cervical adenocarcinoma cell line. It is not an oral squamous cell carcinoma (epidermoid carcinoma) as was originally thought.
KB is a widely used model for multidrug resistance. To help scientists who might use KB for other applications, it would be helpful if authors can refer to KB as a HeLa derivative, and to avoid the terms epidermoid, squamous cell carcinoma, or oral.
I note that the authors performed authentication testing. The information above would help readers to make sense of their test results. For a list of known cross-contaminated cell lines, see http://iclac.org/databases/cross-contaminations/.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2014 Sep 01, Amanda Capes-Davis commented:
The authors describe KB as an epidermoid cell line. Although this term is widely used, it is not accurate for this cell line. KB is known to be cross-contaminated with HeLa and thus is a cervical adenocarcinoma cell line. It is not an oral squamous cell carcinoma (epidermoid carcinoma) as was originally thought.
KB is a widely used model for multidrug resistance. To help scientists who might use KB for other applications, it would be helpful if authors can refer to KB as a HeLa derivative, and to avoid the terms epidermoid, squamous cell carcinoma, or oral.
I note that the authors performed authentication testing. The information above would help readers to make sense of their test results. For a list of known cross-contaminated cell lines, see http://iclac.org/databases/cross-contaminations/.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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