On 2014 Sep 01, Ferenc Zsila commented:

The authors claim that in relation to physiological conditions, cancer cells have substantially lower, acidic intracellular pH.

Abstract: "...under acidic conditions (pH 5.0) mimicking the intracellular pH-conditions."

In page 364: "Specifically, the intracellular pH of tumor cells (pH 5.0-6.5) is usually much lower than physiological pH conditions (pH 7.4), which has encour-aged researchers to develop pH-responsive prodrug formulations to improve therapeutic efficacy."

In contrast to this statement, numerous data show that just the opposite is true: the intracellular pH of cancer cells is modestly alkaline (pH~7.4). Not the intra- but the extracellular milieu of tumours is acidic. Intracellular acidosis leads to cell death.

Reference: Webb BA, 2011

On 2014 Sep 01, Ferenc Zsila commented:

The authors claim that in relation to physiological conditions, cancer cells have substantially lower, acidic intracellular pH.

Abstract: "...under acidic conditions (pH 5.0) mimicking the intracellular pH-conditions."

In page 364: "Specifically, the intracellular pH of tumor cells (pH 5.0-6.5) is usually much lower than physiological pH conditions (pH 7.4), which has encour-aged researchers to develop pH-responsive prodrug formulations to improve therapeutic efficacy."

In contrast to this statement, numerous data show that just the opposite is true: the intracellular pH of cancer cells is modestly alkaline (pH~7.4). Not the intra- but the extracellular milieu of tumours is acidic. Intracellular acidosis leads to cell death.

Reference: Webb BA, 2011