On 2014 Sep 30, Ryan Radecki commented:

Post-publication commentary:

"Are a Third of Research Conclusions Wrong?"

As I covered last year, half of what you’ve been taught in medicine is wrong – we just don’t know which half.

And, it turns out, sometimes even the same authors taking a second look at the same data as before, can come up with new – and wildly different – conclusions.

This is a review of 37 randomized-controlled trials published after 1966 paired with 37 “re-analyses” of the same data. These trials span the entire medical domain, from mycophenolate therapy after cardiac transplantation to homeopathy for fibrosis. Of these 37 re-analyses, 32 of them involved authors from the original research group. These re-analyses differed by changing statistical techniques, outcome definitions, or other study interpretation methods....

http://www.emlitofnote.com/2014/09/are-third-of-research-conclusions-wrong.html

On 2014 Sep 30, Ryan Radecki commented:

Post-publication commentary:

"Are a Third of Research Conclusions Wrong?"

As I covered last year, half of what you’ve been taught in medicine is wrong – we just don’t know which half.

And, it turns out, sometimes even the same authors taking a second look at the same data as before, can come up with new – and wildly different – conclusions.

This is a review of 37 randomized-controlled trials published after 1966 paired with 37 “re-analyses” of the same data. These trials span the entire medical domain, from mycophenolate therapy after cardiac transplantation to homeopathy for fibrosis. Of these 37 re-analyses, 32 of them involved authors from the original research group. These re-analyses differed by changing statistical techniques, outcome definitions, or other study interpretation methods....

http://www.emlitofnote.com/2014/09/are-third-of-research-conclusions-wrong.html