- Jul 2018
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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On 2016 May 27, Eduardo ANGLES-CANO commented:
Comment on "We hypothesized that low factor XII reduces kallikrein formation and consequently the release of bradykinin..." I suggest an alternative explanation, to the oedema hypothesis; a low bradykinin may results in insufficient stimulation to release tPA by the endothelium leading to inefficient thrombus lysis. This is particularly pertinent if we consider that thrombus persistence is finally due to an insufficient fibrinolytic response.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
-
On 2016 May 27, Eduardo ANGLES-CANO commented:
Comment on "We hypothesized that low factor XII reduces kallikrein formation and consequently the release of bradykinin..." I suggest an alternative explanation, to the oedema hypothesis; a low bradykinin may results in insufficient stimulation to release tPA by the endothelium leading to inefficient thrombus lysis. This is particularly pertinent if we consider that thrombus persistence is finally due to an insufficient fibrinolytic response.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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