- Jul 2018
-
europepmc.org europepmc.org
-
On 2016 Mar 13, Lise Bankir commented:
It may be useful to remind that loop diuretics act on the thick ascending limb upstream of the macula densa, whereas the thiazide-type diuretics work donwstream the macula densa. Moreover, loop diuretic block the sodium-chloride cotransporter in the cells of the macula densa. The tubulo-glomerular feedback that permanently regulates the GFR is thus abolished, allowing the GFR to go up. This produces a permanent "hyperfiltration" that is known to induce renal damage when sustained for long periods. Thiazide diuretics, acting beyond, the macula densa should not influence the GFR
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
-
- Feb 2018
-
europepmc.org europepmc.org
-
On 2016 Mar 13, Lise Bankir commented:
It may be useful to remind that loop diuretics act on the thick ascending limb upstream of the macula densa, whereas the thiazide-type diuretics work donwstream the macula densa. Moreover, loop diuretic block the sodium-chloride cotransporter in the cells of the macula densa. The tubulo-glomerular feedback that permanently regulates the GFR is thus abolished, allowing the GFR to go up. This produces a permanent "hyperfiltration" that is known to induce renal damage when sustained for long periods. Thiazide diuretics, acting beyond, the macula densa should not influence the GFR
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
-