On 2016 Jun 16, thomas samaras commented:

The increase in BMI is certainly puzzling in view of a recent study by Aune et al.(2016) that found a BMI of 20-22 was best for non-smokers over the long term. The study involved a meta-analysis of 230 studies involving 30 million subjects and almost 4 million deaths. When BMI increases, most biological factors get worse, starting for a BMI of less than 21(Lamon-Fava). This includes increases in blood pressure, total cholesterol, LDL, TG and lower HDL. Other studies have found that insulin and IGF-1 increase with BMI. Higher levels of insulin and IGF-1 have been found to be inversely related to longevity. Also, APO-B increases with BMI and is related to a higher risk of heart disease. In addition, APO-A decreases with increasing BMI and this trend is associated with increasing heart disease.

On 2016 Jun 16, thomas samaras commented:

The increase in BMI is certainly puzzling in view of a recent study by Aune et al.(2016) that found a BMI of 20-22 was best for non-smokers over the long term. The study involved a meta-analysis of 230 studies involving 30 million subjects and almost 4 million deaths. When BMI increases, most biological factors get worse, starting for a BMI of less than 21(Lamon-Fava). This includes increases in blood pressure, total cholesterol, LDL, TG and lower HDL. Other studies have found that insulin and IGF-1 increase with BMI. Higher levels of insulin and IGF-1 have been found to be inversely related to longevity. Also, APO-B increases with BMI and is related to a higher risk of heart disease. In addition, APO-A decreases with increasing BMI and this trend is associated with increasing heart disease.