On 2016 Aug 03, Murat Büyükşekerci commented:
Dear Sir In Page 26, under title "5.1 Pain Chronification", it is written as 'For example, neurokinin has been shown to both decrease inflammatory pain and joint cartilage destruction in rats [176, 177]. According to referenced atricles it should be like this '..NEUROKİNİN RECEPTOR ANTAGONİSTS.." not neurokinin. Thanks.
On 2016 Aug 02, Murat Büyükşekerci commented:
In page 13 under heading 3.8 Glutamate it is written as "They showed that alpha-2 antagonists inhibit the auto-phosphorylation of CaMKII, proposing that reduced CaMKII activity may lead to dephosphorylation of NMDA and AMPA glutamate receptors and a corresponding decrease in nociceptive transmission [77]." However, as we read the referenced article* clonidin ,an alpha-2 agonist, did inhibit the auto-phosphorylation of CaMKII but not any alpha-2 antagonists. I would like to point this misinterpret. Thank you for considering.
*Wang XT, Lian X, Xu YM, et al. Alpha2 noradrenergic receptor suppressed CaMKII signaling in spinal dorsal horn of mice with inflammatory pain. Eur J Pharmacol 2014;724:16-23.
On 2016 Aug 02, Murat Büyükşekerci commented:
In page 13 under heading 3.8 Glutamate it is written as "They showed that alpha-2 antagonists inhibit the auto-phosphorylation of CaMKII, proposing that reduced CaMKII activity may lead to dephosphorylation of NMDA and AMPA glutamate receptors and a corresponding decrease in nociceptive transmission [77]." However, as we read the referenced article* clonidin ,an alpha-2 agonist, did inhibit the auto-phosphorylation of CaMKII but not any alpha-2 antagonists. I would like to point this misinterpret. Thank you for considering.
*Wang XT, Lian X, Xu YM, et al. Alpha2 noradrenergic receptor suppressed CaMKII signaling in spinal dorsal horn of mice with inflammatory pain. Eur J Pharmacol 2014;724:16-23.
On 2016 Aug 03, Murat Büyükşekerci commented:
Dear Sir In Page 26, under title "5.1 Pain Chronification", it is written as 'For example, neurokinin has been shown to both decrease inflammatory pain and joint cartilage destruction in rats [176, 177]. According to referenced atricles it should be like this '..NEUROKİNİN RECEPTOR ANTAGONİSTS.." not neurokinin. Thanks.