66 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
    1
    1. scibot 02 Dec 2024
      RRID:AB_10013724

      DOI: 10.1016/j.neuron.2024.10.029

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    sciencedirect.com/science/article/pii/S0896627324008006
  3. Nov 2024
  4. 52.53.155.43 52.53.155.43
    effects_of_p301l_tau_on_post_translational.25-html.html
    1
    1. scibot 07 Nov 2024
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      DOI: 10.4103/nrr.nrr-d-23-01742

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    52.53.155.43/6f5189698d9c1b8a18d3fb9b9f3d0cf87ff075d6/effects_of_p301l_tau_on_post_translational.25-html.html
  5. Oct 2024
  6. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mass spectrometry identifies tau C-terminal phosphorylation cluster during neuronal hyperexcitation
    1
    1. scibot 03 Oct 2024
      RRID:AB_10013724

      DOI: 10.1111/jnc.16221

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16221
  7. Sep 2024
  8. www.biorxiv.org www.biorxiv.org
    Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration
    1
    1. scibot 28 Sep 2024
      RRID:AB_10013724

      DOI: 10.1101/2024.09.19.613736

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    biorxiv.org/content/10.1101/2024.09.19.613736v1
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early-Stage Moderate Alcohol Feeding Dysregulates Insulin-Related Metabolic Hormone Expression in the Brain: Potential Links to Neurodegeneration Including Alzheimer’s Disease
    1
    1. scibot 12 Sep 2024
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      DOI: 10.3233/ADR-240026

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    ncbi.nlm.nih.gov/pmc/articles/PMC11380283/
  10. www.sciencedirect.com www.sciencedirect.com
    Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation
    1
    1. scibot 10 Sep 2024
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      DOI: 10.1016/j.crmeth.2024.100858

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    sciencedirect.com/science/article/pii/S2667237524002364
  11. Aug 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy
    1
    1. scibot 30 Aug 2024
      RRID:AB_10013724

      DOI: 10.1002/alz.14074

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    ncbi.nlm.nih.gov/pmc/articles/PMC11350046/
  13. May 2024
  14. www.jneurosci.org www.jneurosci.org
    Human iPSC-derived neurons with reliable synapses and large presynaptic action potentials
    1
    1. scibot 25 May 2024
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      DOI: 10.1523/JNEUROSCI.0971-23.2024

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    jneurosci.org/content/jneuro/early/2024/05/07/JNEUROSCI.0971-23.2024.full.pdf
  15. Apr 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
    1
    1. scibot 16 Apr 2024
      RRID:AB_10013724

      DOI: 10.1016/j.stem.2024.03.013

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    sciencedirect.com/science/article/pii/S1934590924000948
  17. Feb 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioural, metabolic and lipidomic characterisation of the 5xFADxTg30 mouse model of Alzheimer’s Disease.
    1
    1. scibot 01 Feb 2024
      RRID:AB_10013724

      DOI: 10.1016/j.isci.2024.108800

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    ncbi.nlm.nih.gov/pmc/articles/PMC10826307/
  19. Oct 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
    1
    1. scibot 06 Oct 2023
      RRID:AB_10013724

      DOI: 10.1016/j.neuron.2023.08.012

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    sciencedirect.com/science/article/pii/S0896627323006232
  21. Sep 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Agent Orange Causes Metabolic Dysfunction and Molecular Pathology Reminiscent of Alzheimer’s Disease
    1
    1. scibot 07 Sep 2023
      AB_10013724

      DOI: 10.3233/ADR-230046

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    ncbi.nlm.nih.gov/pmc/articles/PMC10473158/
  23. Aug 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
    1
    1. scibot 23 Aug 2023
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2023.112994

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    sciencedirect.com/science/article/pii/S2211124723010057
  25. Jul 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
    1
    1. scibot 05 Jul 2023
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2023.112725

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    sciencedirect.com/science/article/pii/S2211124723007362
  27. Jun 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
    1
    1. scibot 07 Jun 2023
      RRID:AB_10013724

      DOI: 10.1016/j.isci.2023.106905

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    sciencedirect.com/science/article/pii/S2589004223009823
  29. May 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
    1
    1. scibot 23 May 2023
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.2102-22.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10198456/
  31. Nov 2022
  32. academic.oup.com academic.oup.com
    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
    1
    1. scibot 15 Nov 2022
      RRID:AB_10013724

      DOI: 10.1093/brain/awac325

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    academic.oup.com/brain/advance-article/doi/10.1093/brain/awac325/6694190
  33. Sep 2022
  34. www.sciencedirect.com www.sciencedirect.com
    TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy
    1
    1. scibot 11 Sep 2022
      AB_10013724

      DOI: 10.1016/j.crmeth.2022.100292

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    sciencedirect.com/science/article/pii/S2667237522001746
  35. www.sciencedirect.com www.sciencedirect.com
    A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer
    1
    1. scibot 11 Sep 2022
      RRID:AB_10013724

      DOI: 10.1016/j.crmeth.2022.100289

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    sciencedirect.com/science/article/pii/S2667237522001710
  36. Aug 2022
  37. www.sciencedirect.com www.sciencedirect.com
    Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
    1
    1. scibot 26 Aug 2022
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2022.111249

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    sciencedirect.com/science/article/pii/S2211124722010671
  38. Jul 2022
  39. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1-month following repetitive mild traumatic brain injury
    1
    1. scibot 27 Jul 2022
      AB_10013724

      DOI: 10.1111/ejn.15752

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    onlinelibrary.wiley.com/doi/10.1111/ejn.15752
  40. Jun 2022
  41. www.sciencedirect.com www.sciencedirect.com
    Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons
    1
    1. scibot 03 Jun 2022
      RRID:AB_10013724

      DOI: 10.1016/j.stem.2022.04.018

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    sciencedirect.com/science/article/pii/S1934590922002004
  42. May 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Cholesterol determines the cytosolic entry and seeded aggregation of tau
    1
    1. scibot 13 May 2022
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2022.110776

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    sciencedirect.com/science/article/pii/S221112472200540X
  44. link.springer.com link.springer.com
    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
    1
    1. scibot 05 May 2022
      RRID:AB_10013724

      DOI: 10.1186/s13024-022-00526-y

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    link.springer.com/article/10.1186/s13024-022-00526-y
  45. Apr 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model
    1
    1. scibot 27 Apr 2022
      RRID:AB_10013724

      DOI: 10.3390/biom12040505

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    ncbi.nlm.nih.gov/pmc/articles/PMC9027016/
  47. www.sciencedirect.com www.sciencedirect.com
    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
    1
    1. scibot 20 Apr 2022
      RRID:AB_10013724

      DOI: 10.1016/j.immuni.2022.03.018

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    sciencedirect.com/science/article/pii/S1074761322001418
  48. Jan 2022
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies
    1
    1. scibot 28 Jan 2022
      RRID:AB_10013724

      DOI: 10.3233/ADR-210050

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    ncbi.nlm.nih.gov/pmc/articles/PMC8764631/
  50. www.sciencedirect.com www.sciencedirect.com
    Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
    1
    1. scibot 21 Jan 2022
      RRID:AB_10013724

      DOI: 10.1016/j.cell.2021.12.041

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    sciencedirect.com/science/article/pii/S0092867421015634
  51. www.sciencedirect.com www.sciencedirect.com
    Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
    1
    1. scibot 14 Jan 2022
      RRID:AB_10013724

      DOI: 10.1016/j.isci.2021.103658

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    sciencedirect.com/science/article/pii/S258900422101628X
  52. Nov 2021
  53. europepmc.org europepmc.org
    Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog
    1
    1. scibot 29 Nov 2021
      AB_10013724

      DOI: 10.3389/fvets.2021.725386

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    europepmc.org/article/MED/34805331
  54. Sep 2021
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization
    1
    1. scibot 25 Sep 2021
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      DOI: 10.1038/s41598-021-98142-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC8452691/
  56. www.sciencedirect.com www.sciencedirect.com
    Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
    1
    1. scibot 03 Sep 2021
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      DOI: 10.1016/j.neuron.2021.08.003

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    sciencedirect.com/science/article/pii/S089662732100578X
  57. Aug 2021
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 07 Aug 2021
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2018.12.085

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    ncbi.nlm.nih.gov/pmc/articles/PMC6335264/
  59. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
    1
    1. scibot 03 Aug 2021
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.2393-17.2017

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    jneurosci.org/content/37/47/11485
  60. Jul 2021
  61. www.sciencedirect.com www.sciencedirect.com
    ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
    1
    1. scibot 31 Jul 2021
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      DOI: 10.1016/j.cell.2021.07.003

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    sciencedirect.com/science/article/pii/S0092867421008291
  62. www.nature.com www.nature.com
    Untitled document
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    1. scibot 31 Jul 2021
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      DOI: 10.1038/s41598-018-33474-z

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    nature.com/articles/s41598-018-33474-z
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
    1
    1. scibot 30 Jul 2021
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.1550-17.2017

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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  64. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
    2
    1. scibot 27 Jul 2021
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.2393-17.2017

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    2. scibot 27 Jul 2021
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.2393-17.2017

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    jneurosci.org/content/37/47/11485
  65. www.nature.com www.nature.com
    Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures
    2
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      AB_10013724

      DOI: 10.1038/cddis.2017.97

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    2. scibot 27 Jul 2021
      AB_10013724

      DOI: 10.1038/cddis.2017.97

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    nature.com/cddis/journal/v8/n3/full/cddis201797a.html
  66. www.sciencedirect.com www.sciencedirect.com
    Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy
    1
    1. scibot 19 Jul 2021
      RRID: AB_10013724

      DOI: 10.1016/j.ebiom.2019.03.033

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    sciencedirect.com/science/article/pii/S2352396419301732
  67. Jun 2021
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Templated α-synuclein inclusion formation is independent of endogenous tau
    2
    1. scibot 24 Jun 2021
      AB_10013724

      DOI: 10.1523/ENEURO.0458-20.2021

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    2. scibot 24 Jun 2021
      AB_10013724

      DOI: 10.1523/ENEURO.0458-20.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8213444/
  69. May 2021
  70. www.sciencedirect.com www.sciencedirect.com
    Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes
    1
    1. scibot 19 May 2021
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2021.109134

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    sciencedirect.com/science/article/pii/S2211124721004733
  71. Apr 2021
  72. www.sciencedirect.com www.sciencedirect.com
    Tau seeds are subject to aberrant modifications resulting in distinct signatures
    1
    1. scibot 28 Apr 2021
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2021.109037

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    sciencedirect.com/science/article/pii/S2211124721003533
  73. Mar 2021
  74. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Suppression of tau‐induced phenotypes by vitamin E demonstrates the dissociation of oxidative stress and phosphorylation in mechanisms of tau toxicity
    1
    1. scibot 04 Mar 2021
      RRID:AB_10013724

      DOI: 10.1111/jnc.15253

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15253
  75. Feb 2021
  76. www.frontiersin.org www.frontiersin.org
    A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila
    1
    1. scibot 24 Feb 2021
      RRID:AB_10013724

      DOI: 10.3389/fnins.2020.00068

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    frontiersin.org/article/10.3389/fnins.2020.00068/full
  77. Jan 2021
  78. www.sciencedirect.com www.sciencedirect.com
    Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
    1
    1. scibot 20 Jan 2021
      RRID:AB_10013724

      DOI: 10.1016/j.neuron.2020.12.016

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    sciencedirect.com/science/article/pii/S0896627320309983
  79. Dec 2020
  80. www.sciencedirect.com www.sciencedirect.com
    Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease
    1
    1. scibot 07 Dec 2020
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2020.108420

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    sciencedirect.com/science/article/pii/S2211124720314091
  81. Sep 2020
  82. link.springer.com link.springer.com
    Tau reduction in aged mice does not impact Microangiopathy
    1
    1. scibot 25 Sep 2020
      RRID:AB_10013724

      DOI: 10.1186/s40478-020-01014-4

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    link.springer.com/article/10.1186/s40478-020-01014-4
  83. link.springer.com link.springer.com
    The unfolded protein response is activated in the olfactory system in Alzheimer’s disease
    1
    1. scibot 17 Sep 2020
      AB_10013724

      DOI: 10.1186/s40478-020-00986-7

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    link.springer.com/article/10.1186/s40478-020-00986-7
  84. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
    1
    1. scibot 14 Sep 2020
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.1076-19.2019

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    jneurosci.org/content/40/2/459
  85. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L ‐ acan mouse model
    1
    1. scibot 13 Sep 2020
      RRID:AB_10013724

      DOI: 10.1111/ejn.14923

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    onlinelibrary.wiley.com/doi/10.1111/ejn.14923
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability
    1
    1. scibot 08 Sep 2020
      RRID:AB_10013724

      DOI: 10.7554/eLife.57354

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    ncbi.nlm.nih.gov/pmc/articles/PMC7392604/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axon-like protrusions promote small cell lung cancer migration and metastasis
    1
    1. scibot 04 Sep 2020
      RRID:AB_10013724

      DOI: 10.7554/eLife.50616

      Resource: (Agilent Cat# A0024, RRID:AB_10013724)

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    ncbi.nlm.nih.gov/pmc/articles/PMC6940020/
  88. Aug 2020
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axon-like protrusions promote small cell lung cancer migration and metastasis
    1
    1. scibot 16 Aug 2020
      RRID:AB_10013724

      DOI: 10.7554/eLife.50616

      Resource: (Agilent Cat# A0024, RRID:AB_10013724)

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    ncbi.nlm.nih.gov/pmc/articles/PMC6940020/
  90. Jan 2020
  91. www.frontiersin.org www.frontiersin.org
    Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson’s Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_10013724

      DOI: 10.3389/fimmu.2019.02253

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    frontiersin.org/articles/10.3389/fimmu.2019.02253/full
  92. www.sciencedirect.com www.sciencedirect.com
    Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
    1
    1. scibot 13 Jan 2020
      AB_10013724

      DOI: 10.1016/j.neuron.2019.10.010

      Resource: (Agilent Cat# A0024, RRID:AB_10013724)

      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S0896627319308839
  93. www.sciencedirect.com www.sciencedirect.com
    Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2019.08.104

      Resource: (Agilent Cat# A0024, RRID:AB_10013724)

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    sciencedirect.com/science/article/pii/S2211124719311660
  94. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 13 Jan 2020
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2018.12.085

      Resource: (Agilent Cat# A0024, RRID:AB_10013724)

      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S221112471832045X
  95. www.sciencedirect.com www.sciencedirect.com
    Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_10013724

      DOI: 10.1016/j.neuron.2018.10.031

      Resource: (Agilent Cat# A0024, RRID:AB_10013724)

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0896627318309395
  96. Nov 2018
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
    1
    1. scibot 05 Nov 2018
      RRID:AB_10013724

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      (Dako Cat# A0024, RRID:AB_10013724)

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    ncbi.nlm.nih.gov/pmc/articles/PMC6185981/
  98. www.sciencedirect.com www.sciencedirect.com
    Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease
    1
    1. scibot 05 Nov 2018
      RRID:AB_10013724

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0896627318306378
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
    1
    1. scibot 05 Nov 2018
      RRID:AB_10013724

      Curator: @Zeljana_Babic

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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  100. Nov 2017
  101. www.sciencedirect.com www.sciencedirect.com
    Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
    1
    1. scibot 08 Nov 2017
      AB_10013724

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0896627317300582