63 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Circular RNAs trigger nonsense-mediated mRNA decay
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    1. scibot 12 Dec 2024
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      DOI: 10.1016/j.molcel.2024.11.022

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    sciencedirect.com/science/article/pii/S109727652400947X
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    Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit
    1
    1. scibot 10 Dec 2024
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      DOI: 10.1016/j.xcrm.2024.101868

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    sciencedirect.com/science/article/pii/S2666379124006396
  4. Nov 2024
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
    1
    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.chembiol.2024.10.008

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    sciencedirect.com/science/article/pii/S2451945624004434
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
    1
    1. scibot 08 Nov 2024
      RRID:AB_1030947

      DOI: 10.1158/0008-5472.CAN-23-3574

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
  7. Oct 2024
  8. aacrjournals.org aacrjournals.org
    YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1158/0008-5472.CAN-20-0025

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    aacrjournals.org/cancerres/article/80/21/4741/645935/YAP-Mediated-Repression-of-HRK-Regulates-Tumor
  9. Sep 2024
  10. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
    1
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    sciencedirect.com/science/article/pii/S2666379124004245
  11. Aug 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells
    1
    1. scibot 23 Aug 2024
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      DOI: 10.7554/eLife.76940

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    ncbi.nlm.nih.gov/pmc/articles/PMC11333044/
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    LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
    1
    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.cell.2024.07.018

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    sciencedirect.com/science/article/pii/S0092867424007785
  14. Jul 2024
  15. www.sciencedirect.com www.sciencedirect.com
    IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
    1
    1. scibot 24 Jul 2024
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      DOI: 10.1016/j.ccell.2024.05.026

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    sciencedirect.com/science/article/pii/S1535610824002174
  16. Apr 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy
    1
    1. scibot 09 Apr 2024
      2933

      DOI: 10.1016/j.bcp.2024.116198

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    sciencedirect.com/science/article/pii/S0006295224001813
  18. Mar 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
    2
    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.035

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    2. scibot 19 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.035

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    sciencedirect.com/science/article/pii/S109727652400176X
  20. Dec 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
    1
    1. scibot 17 Dec 2023
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    sciencedirect.com/science/article/pii/S2666379123005037
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Statin-induced mitochondrial priming sensitizes multiple myeloma cells to BCL2 and MCL1 inhibitors
    1
    1. scibot 13 Dec 2023
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      DOI: 10.1158/2767-9764.CRC-23-0350

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    ncbi.nlm.nih.gov/pmc/articles/PMC10704957/
  23. www.sciencedirect.com www.sciencedirect.com
    Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113513

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    sciencedirect.com/science/article/pii/S2211124723015255
  24. Nov 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
    1
    1. scibot 22 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101290

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    sciencedirect.com/science/article/pii/S2666379123004846
  26. Oct 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
    1
    1. scibot 20 Oct 2023
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      DOI: 10.1158/0008-5472.CAN-22-1337

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    ncbi.nlm.nih.gov/pmc/articles/PMC10570680/
  28. Sep 2023
  29. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Yin-html.html
    2
    1. scibot 16 Sep 2023
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      DOI: 10.1111/bph.16245

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    52.53.155.43/3f4c3b7a8c80fd686d3f27ef9d97ee6662a4385e/British J Pharmacology - 2023 - Yin-html.html
  30. Aug 2023
  31. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
    2
    1. scibot 18 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101142

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      DOI: 10.1016/j.xcrm.2023.101142

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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  32. Jun 2023
  33. www.sciencedirect.com www.sciencedirect.com
    The potential therapeutic regimen for overcoming resistance to osimertinib due to rare mutations in NSCLC
    1
    1. scibot 24 Jun 2023
      RRID:AB_1030947

      DOI: 10.1016/j.isci.2023.107105

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    sciencedirect.com/science/article/pii/S2589004223011823
  34. Feb 2023
  35. www.sciencedirect.com www.sciencedirect.com
    IFNγ signaling sensitizes melanoma cells to BH3 Mimetics
    1
    1. scibot 04 Feb 2023
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      DOI: 10.1016/j.jid.2023.01.017

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    sciencedirect.com/science/article/pii/S0022202X23000726
  36. Nov 2022
  37. aacrjournals.org aacrjournals.org
    p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness
    1
    1. scibot 22 Nov 2022
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      DOI: 10.1158/1078-0432.CCR-22-1357

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    aacrjournals.org/clincancerres/article/28/21/4757/709842/p53-Inhibits-Bmi-1-driven-Self-Renewal-and-Defines
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
    1
    1. scibot 18 Nov 2022
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      DOI: 10.1016/j.isci.2022.105458

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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  39. Oct 2022
  40. 52.53.155.43 52.53.155.43
    ccr-22-1357-html.html
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      DOI: 10.1158/1078-0432.ccr-22-1357

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    52.53.155.43/b06e31323fa05ae99a3ee4406ee4cfeac8533d8b/ccr-22-1357-html.html
  41. Sep 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
    1
    1. scibot 28 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111433

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    sciencedirect.com/science/article/pii/S2211124722012748
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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    1. scibot 27 Sep 2022
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      DOI: 10.1016/j.jbc.2022.102532

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    sciencedirect.com/science/article/pii/S0021925822009759
  44. Aug 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
    1
    1. scibot 23 Aug 2022
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      DOI: 10.1016/j.crmeth.2022.100271

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    sciencedirect.com/science/article/pii/S2667237522001485
  46. Jul 2022
  47. www.embopress.org www.embopress.org
    LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance
    1
    1. scibot 09 Jul 2022
      RRID:AB_1030947

      DOI: 10.15252/embr.202154195

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    embopress.org/doi/10.15252/embr.202154195
  48. Jun 2022
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
    1
    1. scibot 25 Jun 2022
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      DOI: 10.1016/j.isci.2022.104518

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    ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
    1
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      DOI: 10.1016/j.isci.2022.104517

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    sciencedirect.com/science/article/pii/S258900422200788X
  51. May 2022
  52. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
    1
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      RRID:AB_1030947

      DOI: 10.1158/2159-8290.CD-21-1168

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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  53. Mar 2022
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors
    1
    1. scibot 26 Mar 2022
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      DOI: 10.1016/j.chom.2017.04.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC8938989/
  55. Jan 2022
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
    1
    1. scibot 15 Jan 2022
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      DOI: 10.1038/s41408-021-00603-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  57. Oct 2021
  58. www.sciencedirect.com www.sciencedirect.com
    Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
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    1. scibot 08 Oct 2021
      2933T

      DOI: 10.1016/j.stem.2021.09.009

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    sciencedirect.com/science/article/pii/S1934590921003854
  59. Aug 2021
  60. www.nature.com www.nature.com
    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
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      RRID:AB_1030947

      DOI: 10.1038/s41467-021-24821-2

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    nature.com/articles/s41467-021-24821-2
  61. www.sciencedirect.com www.sciencedirect.com
    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
    1
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      RRID:AB_1030947

      DOI: 10.1016/j.cmet.2019.01.011

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    sciencedirect.com/science/article/pii/S1550413119300117
  62. Jul 2021
  63. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
    1
    1. scibot 31 Jul 2021
      rabbit anti‐BIM

      DOI: 10.1002/ijc.32709

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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32709
  64. www.sciencedirect.com www.sciencedirect.com
    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
    1
    1. scibot 28 Jul 2021
      RRID:AB_1030947

      DOI: 10.1016/j.cmet.2019.01.011

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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
    1
    1. scibot 28 Jul 2021
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      DOI: 10.1038/s41408-018-0165-5

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  66. www.sciencedirect.com www.sciencedirect.com
    Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
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      RRID:AB_103947

      DOI: 10.1016/j.celrep.2019.05.020

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  67. www.sciencedirect.com www.sciencedirect.com
    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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      2933

      DOI: 10.1016/j.biocel.2021.106028

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    sciencedirect.com/science/article/pii/S1357272521001060
  68. Apr 2021
  69. www.sciencedirect.com www.sciencedirect.com
    Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells
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      RRID:AB_1030947

      DOI: 10.1016/j.cmet.2020.10.022

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  70. www.sciencedirect.com www.sciencedirect.com
    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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      RRID:AB_1030947

      DOI: 10.1016/j.ccell.2020.10.010

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  71. www.sciencedirect.com www.sciencedirect.com
    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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      RRID:AB_1030947

      DOI: 10.1016/j.ccell.2020.04.016

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    sciencedirect.com/science/article/pii/S1535610820302154
  72. www.sciencedirect.com www.sciencedirect.com
    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
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      RRID:AB_1030947

      DOI: 10.1016/j.celrep.2021.108966

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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
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      RRID:AB_1030947

      DOI: 10.1016/j.cell.2021.02.019

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  74. Sep 2020
  75. www.sciencedirect.com www.sciencedirect.com
    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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      RRID:AB_1030947

      DOI: 10.1016/j.ccell.2019.12.006

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  76. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.
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      RRID:AB_1030947

      DOI: 10.1158/1078-0432.CCR-19-1900

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  77. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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      RRID:AB_1030947

      DOI: 10.1016/j.celrep.2020.107764

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  78. www.sciencedirect.com www.sciencedirect.com
    Kinetic Heterogeneity of Cancer Cell Fractional Killing
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      RRID:AB_1030947

      DOI: 10.1016/j.celrep.2020.107845

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    sciencedirect.com/science/article/pii/S2211124720308263
  79. Jan 2020
  80. www.sciencedirect.com www.sciencedirect.com
    TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
    1
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      RRID:AB_1030947

      DOI: 10.1016/j.immuni.2019.09.013

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  81. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      RRID:AB_1030947

      DOI: 10.1111/bph.14674

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14674
  82. mbio.asm.org mbio.asm.org
    TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function
    1
    1. scibot 13 Jan 2020
      RRID:AB_1030947

      DOI: 10.1128/mBio.02638-19

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    mbio.asm.org/content/10/6/e02638-19
  83. www.sciencedirect.com www.sciencedirect.com
    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
    1
    1. scibot 13 Jan 2020
      RRID:AB_1030947

      DOI: 10.1016/j.celrep.2019.05.043

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    sciencedirect.com/science/article/pii/S2211124719306631
  84. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_1030947

      DOI: 10.1016/j.celrep.2019.02.108

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    sciencedirect.com/science/article/pii/S2211124719302943
  85. www.sciencedirect.com www.sciencedirect.com
    BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
    1
    1. scibot 13 Jan 2020
      RRID:AB_1030947

      DOI: 10.1016/j.ccell.2019.04.005

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    sciencedirect.com/science/article/pii/S1535610819302004
  86. www.sciencedirect.com www.sciencedirect.com
    Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R−STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity
    1
    1. scibot 13 Jan 2020
      RRID:AB_1030947

      DOI: 10.1016/j.immuni.2018.10.010

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    sciencedirect.com/science/article/pii/S1074761318304758
  87. Nov 2018
  88. www.sciencedirect.com www.sciencedirect.com
    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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      RRID:AB_1030947

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    sciencedirect.com/science/article/pii/S1535610818302691
  89. Nov 2017
  90. www.jneurosci.org www.jneurosci.org
    Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke
    1
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      AB_1030947

      Curator: @Zeljana_Babic

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    jneurosci.org/content/37/7/1797
  91. www.sciencedirect.com www.sciencedirect.com
    CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors
    1
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      AB_1030947

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1931312817301518
  92. www.sciencedirect.com www.sciencedirect.com
    Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
    1
    1. scibot 08 Nov 2017
      AB_1030947

      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S0092867417302465