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NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3904
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12221223/
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Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3267
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12398951/
Aug 2025
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De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer

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1. scibot 05 Aug 2025
  
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  DOI: 10.1038/s41467-025-61242-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12311037/
Jul 2025
www.biorxiv.org www.biorxiv.org

Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance

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1. scibot 11 Jul 2025
  
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  DOI: 10.1101/2025.06.24.661170
  
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biorxiv.org/content/10.1101/2025.06.24.661170v1
Jun 2025
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Holothurian Glycosaminoglycan (hGAG) Promoted Bim-Induced Apoptosis in Human Lung Adenocarcinoma A549 Cell Line Through Inhibition of Akt-Mediated FOXO3a Translocation

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1. scibot 21 Jun 2025
  
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journals.sagepub.com/doi/full/10.1177/15347354251341442
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.redox.2025.103649
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
52.53.155.43 52.53.155.43

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1. scibot 15 Jun 2025
  
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52.53.155.43/40d57cf5e469615dd789036d1af2f800d0eb4416/PDF-html.html
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1. scibot 13 Jun 2025
  
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52.53.155.43/39661a60067369c81e4f8c30deffb29c14ec6c80/PDF-html.html
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Holothurian Glycosaminoglycan (hGAG) Promoted Bim-Induced Apoptosis in Human Lung Adenocarcinoma A549 Cell Line Through Inhibition of Akt-Mediated FOXO3a Translocation

1
1. scibot 12 Jun 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12144356/
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Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.chembiol.2025.05.005
  
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sciencedirect.com/science/article/pii/S2451945625001667
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KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression

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1. scibot 03 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12302258/
May 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225008454-main-html.html

1
1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112584
  
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52.53.155.43/2f59eea255f6dfa2798e1e0fcb3d7e10d3ba6bc8/1-s2.0-S2589004225008454-main-html.html
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-2548
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11964295/
Feb 2025
52.53.155.43 52.53.155.43

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  DOI: 10.1158/1078-0432.ccr-24-2548
  
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52.53.155.43/f141eddf8d6ed9d4f64a9be0f6055059836b8d11/PDF-html.html
Dec 2024
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Circular RNAs trigger nonsense-mediated mRNA decay

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.022
  
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sciencedirect.com/science/article/pii/S109727652400947X
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Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101868
  
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sciencedirect.com/science/article/pii/S2666379124006396
Nov 2024
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A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.chembiol.2024.10.008
  
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Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-3574
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
Oct 2024
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YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma

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1. scibot 02 Oct 2024
  
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  DOI: 10.1158/0008-5472.CAN-20-0025
  
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aacrjournals.org/cancerres/article/80/21/4741/645935/YAP-Mediated-Repression-of-HRK-Regulates-Tumor
Sep 2024
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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  DOI: 10.1016/j.xcrm.2024.101703
  
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sciencedirect.com/science/article/pii/S2666379124004245
Aug 2024
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Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells

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1. scibot 23 Aug 2024
  
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  DOI: 10.7554/eLife.76940
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11333044/
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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.cell.2024.07.018
  
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sciencedirect.com/science/article/pii/S0092867424007785
Jul 2024
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IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma

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1. scibot 24 Jul 2024
  
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  DOI: 10.1016/j.ccell.2024.05.026
  
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Apr 2024
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Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy

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1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.bcp.2024.116198
  
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sciencedirect.com/science/article/pii/S0006295224001813
Mar 2024
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Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1

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1. scibot 19 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.035
  
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Dec 2023
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Econazole selectively induces cell death in NF1-homozygous mutant tumor cells

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1. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.xcrm.2023.101309
  
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Statin-induced mitochondrial priming sensitizes multiple myeloma cells to BCL2 and MCL1 inhibitors

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1. scibot 13 Dec 2023
  
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  DOI: 10.1158/2767-9764.CRC-23-0350
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10704957/
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Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death

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  DOI: 10.1016/j.celrep.2023.113513
  
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sciencedirect.com/science/article/pii/S2211124723015255
Nov 2023
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Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

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1. scibot 22 Nov 2023
  
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  DOI: 10.1016/j.xcrm.2023.101290
  
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sciencedirect.com/science/article/pii/S2666379123004846
Oct 2023
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Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

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1. scibot 20 Oct 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-1337
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10570680/
Sep 2023
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British J Pharmacology - 2023 - Yin-html.html

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1. scibot 16 Sep 2023
  
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  DOI: 10.1111/bph.16245
  
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  DOI: 10.1111/bph.16245
  
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52.53.155.43/3f4c3b7a8c80fd686d3f27ef9d97ee6662a4385e/British J Pharmacology - 2023 - Yin-html.html
Aug 2023
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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Jun 2023
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The potential therapeutic regimen for overcoming resistance to osimertinib due to rare mutations in NSCLC

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IFNγ signaling sensitizes melanoma cells to BH3 Mimetics

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p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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ccr-22-1357-html.html

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Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice

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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling

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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

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Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

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Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia

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EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

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Mar 2022
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CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors

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Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)

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Oct 2021
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Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis

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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

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Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity

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Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis

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Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity

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Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells

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Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

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Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

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Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

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MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

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UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

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In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

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5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

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Kinetic Heterogeneity of Cancer Cell Fractional Killing

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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

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BPS Publications

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  DOI: 10.1111/bph.14674
  
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TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function

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Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

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  DOI: 10.1016/j.celrep.2019.05.043
  
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  DOI: 10.1016/j.celrep.2019.02.108
  
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BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models

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  DOI: 10.1016/j.ccell.2019.04.005
  
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Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R−STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity

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  DOI: 10.1016/j.immuni.2018.10.010
  
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke

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1. scibot 08 Nov 2017
  
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CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors

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1. scibot 08 Nov 2017
  
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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

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1. scibot 08 Nov 2017
  
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  AB_1030947
  
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