87 Matching Annotations
  1. Mar 2026
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    Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions
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    sciencedirect.com/science/article/pii/S0896627326000899
  3. Aug 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12335005/
  5. Jul 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuronal Deletion of Tumor Susceptibility Gene 101 (Tsg101) Causes Rapid Apoptotic Loss of Hippocampal CA3 Neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12191344/
  7. Jun 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity
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    pmc.ncbi.nlm.nih.gov/articles/PMC6400570/
  9. May 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluation of aggrephagy markers in myofibrillar myopathies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12102939/
  11. Apr 2025
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    pmc.ncbi.nlm.nih.gov/articles/PMC12045345/
  13. Nov 2024
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity in fission yeast
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    pmc.ncbi.nlm.nih.gov/articles/PMC11513537/
  15. Sep 2024
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    Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform
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    sciencedirect.com/science/article/pii/S1534580719305696
  17. Jul 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit
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    ncbi.nlm.nih.gov/pmc/articles/PMC10868424/
  19. Jun 2024
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    Bacterial esterases reverse lipopolysaccharide ubiquitylation to block host immunity
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    sciencedirect.com/science/article/pii/S193131282400132X
  21. May 2024
  22. www.science.org www.science.org
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    science.org/doi/10.1126/sciadv.adl6082
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    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068011/
  24. Apr 2024
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    Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties
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    sciencedirect.com/science/article/pii/S0092867424003155
  26. Dec 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10749615/
  28. Aug 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10425945/
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    Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3
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    sciencedirect.com/science/article/pii/S2451945623002337
  31. May 2023
  32. www.nature.com www.nature.com
    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
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    nature.com/articles/s41467-022-31905-0
  33. Apr 2023
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    Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair
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    sciencedirect.com/science/article/pii/S1097276523002113
  35. Oct 2022
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy controls Wolbachia infection upon bacterial damage and in aging Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC9589277/
  37. Sep 2022
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    Target protein localization and its impact on PROTAC-mediated degradation
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    sciencedirect.com/science/article/pii/S2451945622003129
  39. Aug 2022
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    TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
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    sciencedirect.com/science/article/pii/S1097276522006633
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    Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit
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    ncbi.nlm.nih.gov/pmc/articles/PMC10868424/
  42. Mar 2022
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8880992/
  44. Feb 2022
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8835362/
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    Neuropeptide signaling and SKN-1 orchestrate differential responses of the proteostasis network to dissimilar proteotoxic insults
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    sciencedirect.com/science/article/pii/S2211124722000663
  47. Jan 2022
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    Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
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    sciencedirect.com/science/article/pii/S2589004221016205
  49. Dec 2021
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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    sciencedirect.com/science/article/pii/S2211124721015710
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    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
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    sciencedirect.com/science/article/pii/S1550413121005398
  52. Aug 2021
  53. www.sciencedirect.com www.sciencedirect.com
    Coordination of tumor growth and host wasting by tumor-derived Upd3
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    sciencedirect.com/science/article/pii/S2211124721009876
  54. academic.oup.com academic.oup.com
    RNF8 is not required for histone-to-protamine exchange in spermiogenesis
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    academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/ioab132/6315290
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates
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    ncbi.nlm.nih.gov/pmc/articles/PMC6477179/
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    The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling
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    sciencedirect.com/science/article/pii/S2211124721008895
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum
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    ncbi.nlm.nih.gov/pmc/articles/PMC6483976/
  59. Jul 2021
  60. academic.oup.com academic.oup.com
    Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment
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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddz255/5613690
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    SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance
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    sciencedirect.com/science/article/pii/S2211124721008512
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  64. elifesciences.org elifesciences.org
    Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense
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    elifesciences.org/content/6/e21465
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    Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
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    sciencedirect.com/science/article/pii/S1534580721005165
  66. May 2021
  67. www.sciencedirect.com www.sciencedirect.com
    Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters
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    RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins
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    sciencedirect.com/science/article/pii/S1097276520304251
  69. www.cell.com www.cell.com
    The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia
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    cell.com/iscience/abstract/S2589-0042(21)00403-X
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    Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging
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  71. Apr 2021
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    Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity
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    Coordinate regulation of the senescent state by selective autophagy
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  74. Mar 2021
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    Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy
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    sciencedirect.com/science/article/pii/S2211124721001716
  76. Feb 2021
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuroprotective activity of ursodeoxycholic acid in CHMP2BIntron5 models of frontotemporal dementia
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    ncbi.nlm.nih.gov/pmc/articles/PMC7491204/
  78. Sep 2020
  79. www.sciencedirect.com www.sciencedirect.com
    Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair
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    sciencedirect.com/science/article/pii/S0092867420301549
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    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    elifesciences.org/articles/37993
  81. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
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    Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth
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    Mimicry Embedding Facilitates Advanced Neural Network Training for Image-Based Pathogen Detection
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    The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
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    Neuroprotective activity of ursodeoxycholic acid in CHMP2BIntron5 models of frontotemporal dementia
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  86. Jan 2020
  87. www.sciencedirect.com www.sciencedirect.com
    In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast
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    Proteostasis is essential during cochlear development for neuron survival and hair cell polarity
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    embopress.org/doi/abs/10.15252/embr.201847097
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    A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism
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    ncbi.nlm.nih.gov/pmc/articles/PMC6897512/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity
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    The N-Degron Pathway Mediates ER-phagy
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    PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development
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    Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A
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    The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
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    embopress.org/doi/10.15252/embj.2019102361
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    Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance
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    Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements
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    sciencedirect.com/science/article/pii/S1097276518310979
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining host–pathogen interactions employing an artificial intelligence workflow
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    ncbi.nlm.nih.gov/pmc/articles/PMC6372283/
  102. Nov 2018
  103. www.sciencedirect.com www.sciencedirect.com
    Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
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    BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor
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    The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection
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    Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
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    The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming
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    PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response
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    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
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    sciencedirect.com/science/article/pii/S1097276518301424
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    Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway
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    sciencedirect.com/science/article/pii/S1097276517308067
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  113. Nov 2017
  114. www.jneurosci.org www.jneurosci.org
    Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels
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    jneurosci.org/content/37/9/2485
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin
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    ncbi.nlm.nih.gov/pmc/articles/PMC5438252/
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    A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity
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    A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A conformational switch regulates the ubiquitin ligase HUWE1
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    ncbi.nlm.nih.gov/pmc/articles/PMC5308896/
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    Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination
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    sciencedirect.com/science/article/pii/S0092867416315914