62 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.devcel.2020.07.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  3. Jun 2024
  4. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
    1
    1. scibot 21 Jun 2024
      RRID:AB_10547134

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    sciencedirect.com/science/article/pii/S1550413124001918
  5. May 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
    1
    1. scibot 17 May 2024
      RRID:AB_10547134

      DOI: 10.1016/j.ajpath.2024.04.006

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    sciencedirect.com/science/article/pii/S0002944024001743
  7. Apr 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
    1
    1. scibot 24 Apr 2024
      RRID:AB_10547134

      DOI: 10.1093/narcan/zcae018

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
  9. Mar 2024
  10. www.sciencedirect.com www.sciencedirect.com
    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
    2
    1. scibot 07 Mar 2024
      RRID:AB_10547134

      DOI: 10.1016/j.isci.2024.109188

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    sciencedirect.com/science/article/pii/S2589004224004097
  11. Feb 2024
  12. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
    3
    1. scibot 09 Feb 2024
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      DOI: 10.1101/2023.12.05.570182

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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  13. Nov 2023
  14. www.sciencedirect.com www.sciencedirect.com
    Tsc2 coordinates neuroprogenitor differentiation
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.isci.2023.108442

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    sciencedirect.com/science/article/pii/S2589004223025191
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    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
    1
    1. scibot 14 Nov 2023
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      DOI: 10.1016/j.molcel.2021.03.010

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    sciencedirect.com/science/article/pii/S1097276521001787
  16. Oct 2023
  17. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
    1
    1. scibot 25 Oct 2023
      RRID:AB_10547134

      DOI: 10.1016/j.molcel.2021.03.009

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    Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex
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    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.celrep.2023.112838

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    ncbi.nlm.nih.gov/pmc/articles/PMC10529098/
  19. Apr 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.neuron.2023.04.006

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    sciencedirect.com/science/article/pii/S0896627323002684
  21. Mar 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neurovascular development in Pten and Tsc2 mouse mutants
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      DOI: 10.1523/ENEURO.0340-22.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC9953070/
  23. Jan 2023
  24. academic.oup.com academic.oup.com
    Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy
    1
    1. scibot 26 Jan 2023
      RRID:AB_10547134

      DOI: 10.1210/endocr/bqac213

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    academic.oup.com/endo/article/164/3/bqac213/6967060
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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    1. scibot 12 Jan 2023
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      DOI: 10.1016/j.celrep.2022.111976

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    sciencedirect.com/science/article/pii/S2211124722018800
  26. Dec 2022
  27. www.science.org www.science.org
    Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension
    1
    1. scibot 13 Dec 2022
      RRID:AB_10547134

      DOI: 10.1126/scisignal.abn2743

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    science.org/doi/10.1126/scisignal.abn2743
  28. Aug 2022
  29. www.sciencedirect.com www.sciencedirect.com
    Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing
    1
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      RRID:AB_10547134

      DOI: 10.1016/j.celrep.2022.111192

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    sciencedirect.com/science/article/pii/S2211124722010099
  30. Jul 2022
  31. www.sciencedirect.com www.sciencedirect.com
    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
    1
    1. scibot 02 Jul 2022
      RRID:AB_10547134

      DOI: 10.1016/j.molcel.2022.06.008

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    sciencedirect.com/science/article/pii/S1097276522005445
  32. May 2022
  33. www.sciencedirect.com www.sciencedirect.com
    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
    1
    1. scibot 19 May 2022
      RRID:AB_10547134

      DOI: 10.1016/j.celrep.2022.110824

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    sciencedirect.com/science/article/pii/S2211124722005952
  34. Mar 2022
  35. www.sciencedirect.com www.sciencedirect.com
    Rheb regulates nuclear mTORC1 activity independent of farnesylation
    1
    1. scibot 26 Mar 2022
      RRID:AB_10547134

      DOI: 10.1016/j.chembiol.2022.02.006

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    sciencedirect.com/science/article/pii/S2451945622000873
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
    1
    1. scibot 02 Mar 2022
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      DOI: 10.1016/j.devcel.2022.02.004

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    sciencedirect.com/science/article/pii/S1534580722000703
  37. Feb 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling
    1
    1. scibot 23 Feb 2022
      #4308; Cell Signaling Technology

      DOI: 10.1016/j.yexcr.2022.113079

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    sciencedirect.com/science/article/pii/S0014482722000726
  39. Nov 2021
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors
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    1. scibot 05 Nov 2021
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      DOI: 10.1158/0008-5472.CAN-20-3232

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    ncbi.nlm.nih.gov/pmc/articles/PMC8137641/
  41. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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      DOI: 10.1007/s00213-021-06015-2

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    link.springer.com/article/10.1007/s00213-021-06015-2
  42. Sep 2021
  43. www.sciencedirect.com www.sciencedirect.com
    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
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    1. scibot 22 Sep 2021
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      DOI: 10.1016/j.molcel.2021.09.001

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    sciencedirect.com/science/article/pii/S1097276521007358
  44. Aug 2021
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    1. scibot 08 Aug 2021
      RRID:AB_10547134

      DOI: 10.1111/jnc.14311

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14311
  46. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 03 Aug 2021
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      DOI: 10.1016/j.stem.2018.11.021

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    sciencedirect.com/science/article/pii/S1934590918305575
  47. Jul 2021
  48. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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    1. scibot 29 Jul 2021
      TSC2

      DOI: 10.1016/j.ccell.2017.09.013

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    sciencedirect.com/science/article/pii/S1535610817304178
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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    1. scibot 27 Jul 2021
      RRID:AB_10547134

      DOI: 10.1111/jnc.14311

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14311
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    Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma
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    1. scibot 27 Jul 2021
      RRID:AB_10547134

      DOI: 10.7150/thno.35458

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      Curator comments: Tuberin/TSC2 (D93F12) XP Rabbit MAb Antibody Cell Signaling Technology Cat# 4308

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    ncbi.nlm.nih.gov/pmc/articles/PMC6691382/
  51. www.sciencedirect.com www.sciencedirect.com
    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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    1. scibot 10 Jul 2021
      RRID:AB_10547134

      DOI: 10.1016/j.molcel.2021.06.017

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    sciencedirect.com/science/article/pii/S1097276521004974
  52. May 2021
  53. www.sciencedirect.com www.sciencedirect.com
    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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      RRID:AB_10547134

      DOI: 10.1016/j.molcel.2021.04.019

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    sciencedirect.com/science/article/pii/S1097276521003245
  54. www.sciencedirect.com www.sciencedirect.com
    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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      RRID:AB_10547134

      DOI: 10.1016/j.devcel.2020.08.006

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    sciencedirect.com/science/article/pii/S1534580720306304
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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      RRID:AB_10547134

      DOI: 10.1016/j.devcel.2020.07.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  56. Apr 2021
  57. www.sciencedirect.com www.sciencedirect.com
    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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      DOI: 10.1016/j.cmet.2020.08.007

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    sciencedirect.com/science/article/pii/S1550413120304204
  58. www.sciencedirect.com www.sciencedirect.com
    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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      DOI: 10.1016/j.ccell.2020.04.016

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    sciencedirect.com/science/article/pii/S1535610820302154
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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      RRID:AB_10547134

      DOI: 10.7554/eLife.63326

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    ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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      DOI: 10.1016/j.molcel.2021.03.009

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    sciencedirect.com/science/article/pii/S1097276521001775
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    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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      DOI: 10.1016/j.molcel.2021.03.010

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    sciencedirect.com/science/article/pii/S1097276521001787
  62. Jan 2021
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    1
    1. scibot 26 Jan 2021
      RRID:AB_10547134

      DOI: 10.1016/j.cell.2020.12.024

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    ncbi.nlm.nih.gov/pmc/articles/PMC7868890/
  64. Nov 2020
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
    1
    1. scibot 21 Nov 2020
      RRID:AB_10547134

      DOI: 10.7554/eLife.55994

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    ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
  66. Oct 2020
  67. www.sciencedirect.com www.sciencedirect.com
    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
    1
    1. scibot 07 Oct 2020
      RRID:AB_10547134

      DOI: 10.1016/j.celrep.2020.108230

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    sciencedirect.com/science/article/pii/S2211124720312195
  68. Sep 2020
  69. www.sciencedirect.com www.sciencedirect.com
    Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
    1
    1. scibot 17 Sep 2020
      RRID:AB_10547134

      DOI: 10.1016/j.str.2020.05.008

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    sciencedirect.com/science/article/pii/S0969212620301775
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
    1
    1. scibot 16 Sep 2020
      RRID:AB_10547134

      DOI: 10.1523/JNEUROSCI.0642-19.2019

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  71. www.sciencedirect.com www.sciencedirect.com
    Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia
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    1. scibot 12 Sep 2020
      RRID:AB_10547134

      DOI: 10.1016/j.celrep.2020.107780

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    sciencedirect.com/science/article/pii/S2211124720307609
  72. www.sciencedirect.com www.sciencedirect.com
    Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis
    1
    1. scibot 07 Sep 2020
      RRID:AB_10547134

      DOI: 10.1016/j.devcel.2020.02.015

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    sciencedirect.com/science/article/pii/S1534580720301428
  73. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
    1
    1. scibot 04 Sep 2020
      TSC2

      DOI: 10.15252/embr.201949898

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    embopress.org/doi/abs/10.15252/embr.201949898
  74. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells
    1
    1. scibot 04 Sep 2020
      RRID:AB_10547134

      DOI: 10.1016/j.celrep.2020.03.038

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    pubmed.ncbi.nlm.nih.gov/32294437/
  75. academic.oup.com academic.oup.com
    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
    1
    1. scibot 03 Sep 2020
      TSC2

      DOI: 10.1093/jb/mvaa076

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    academic.oup.com/jb/article/doi/10.1093/jb/mvaa076/5870373
  76. Jan 2020
  77. www.eneuro.org www.eneuro.org
    Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia
    1
    1. scibot 13 Jan 2020
      RRID:AB_10547134

      DOI: 10.1523/ENEURO.0168-19.2019

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    eneuro.org/content/6/3/ENEURO.0168-19.2019
  78. academic.oup.com academic.oup.com
    Cartilage ablation of Sirt1 causes inhibition of growth plate chondrogenesis by hyperactivation of mTORC1 signaling
    1
    1. scibot 13 Jan 2020
      RRID:AB_10547134

      DOI: 10.1210/en.2019-00427

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    academic.oup.com/endo/article/160/12/3001/5584418
  79. www.sciencedirect.com www.sciencedirect.com
    TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency
    1
    1. scibot 13 Jan 2020
      RRID:AB_10547134

      DOI: 10.1016/j.molcel.2019.02.032

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    sciencedirect.com/science/article/pii/S1097276519301431
  80. www.sciencedirect.com www.sciencedirect.com
    Lysosome Positioning Influences mTORC2 and AKT Signaling
    1
    1. scibot 12 Jan 2020
      RRID:AB_10547134

      DOI: 10.1016/j.molcel.2019.05.009

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    sciencedirect.com/science/article/pii/S1097276519303624
  81. Nov 2018
  82. www.sciencedirect.com www.sciencedirect.com
    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
    1
    1. scibot 05 Nov 2018
      RRID:AB_10547134

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    sciencedirect.com/science/article/pii/S0092867418305865
  83. www.sciencedirect.com www.sciencedirect.com
    Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
    1
    1. scibot 05 Nov 2018
      RRID:AB_10547134

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    sciencedirect.com/science/article/pii/S1097276518302685
  84. www.sciencedirect.com www.sciencedirect.com
    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
    1
    1. scibot 05 Nov 2018
      RRID:AB_10547134

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    sciencedirect.com/science/article/pii/S1074761317304855
  85. academic.oup.com academic.oup.com
    Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice
    1
    1. scibot 05 Nov 2018
      AB_10547134

      Curator: @evieth

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    academic.oup.com/endo/article/159/1/519/4562294
  86. www.sciencedirect.com www.sciencedirect.com
    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
    1
    1. scibot 05 Nov 2018
      RRID:AB_10547134

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    sciencedirect.com/science/article/pii/S0092867417312631
  87. Nov 2017
  88. www.sciencedirect.com www.sciencedirect.com
    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
    1
    1. scibot 09 Nov 2017
      RRID:AB_10547134

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1097276517304914
  89. www.sciencedirect.com www.sciencedirect.com
    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
    1
    1. scibot 08 Nov 2017
      AB_10547134

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S1097276516308991