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Modeling response to the KRAS-G12C inhibitor AZD4625 in KRASG12C NSCLC patient-derived xenografts reveals insights into primary resistance mechanisms

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TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis

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Sep 2025
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RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity

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Aug 2025
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ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis

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Jul 2025
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Jun 2025
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Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences

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VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells

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Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation

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Mar 2025
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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

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Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis

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Feb 2025
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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism

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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

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Dec 2024
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Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma

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IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages

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Reactive oxygen species control protein degradation at the mitochondrial import gate

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Aug 2024
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
May 2024
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Comprehensive proteogenomic characterization of rare kidney tumors

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

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Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma

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Feb 2024
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Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

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Jan 2024
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FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy

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Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B

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Dec 2023
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Synonymous codon usage regulates translation initiation

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Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

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Oct 2023
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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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Sep 2023
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Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

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Jul 2023
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Orphan quality control shapes network dynamics and gene expression

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Jun 2023
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DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer

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Apr 2023
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Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals

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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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Nov 2022
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LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

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  DOI: 10.7554/eLife.81559
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9674348/
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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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  DOI: 10.1016/j.isci.2022.105458
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
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Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

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OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy

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Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer

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Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex

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Co-adaptor driven assembly of a CUL3 E3 ligase complex

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Triple targeting of breast tumors driven by hormonal receptors and HER2

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Macrophages are metabolically heterogeneous within the tumor microenvironment

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Enteric glial cell heterogeneity regulates intestinal stem cell niches

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Reprogramming of glucocorticoid receptor function by hypoxia

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Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis

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RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal

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Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification

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FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer

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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

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KDM5A mutations identified in autism spectrum disorder using forward genetics

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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

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Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities

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STAT3‐dependent regulation of the electrogenic Na+/HCO3− cotransporter 1 (NBCe1) functional expression in cortical astrocytes

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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

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Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts

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Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

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A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers

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Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

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Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

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Generation of human iPS cell line IBCHi001-A from dentatorubral–pallidoluysian atrophy patient's fibroblasts

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Passive heat therapy protects against endothelial cell hypoxia‐reoxygenation via effects of elevations in temperature and circulating factors

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Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

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Untitled document

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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6103745/
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The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1097276518300601
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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

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  (Cell Signaling Technology Cat# 4650, RRID:AB_10559207)
  
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sciencedirect.com/science/article/pii/S1535610817305159
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Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

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1. scibot 05 Nov 2018
  
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  RRID:AB_10559207
  
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  (Cell Signaling Technology Cat# 4650, RRID:AB_10559207)
  
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sciencedirect.com/science/article/pii/S1550413117307246
Nov 2017
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Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

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1. scibot 08 Nov 2017
  
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  Curator: @Jmenke
  
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  (Cell Signaling Technology Cat# 4650, RRID:AB_10559207)
  
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  RRID:AB_10559207 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413117304941

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