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  1. Last 7 days
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    An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation
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    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009689
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    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    sciencedirect.com/science/article/pii/S2211124724008131
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    APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size
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    ncbi.nlm.nih.gov/pmc/articles/PMC10857907/
  5. Jul 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction
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    ncbi.nlm.nih.gov/pmc/articles/PMC7945993/
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    High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila
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    1. scibot 20 Jul 2024
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      DOI: 10.7554/eLife.53103

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    ncbi.nlm.nih.gov/pmc/articles/PMC7274782/
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    Dimerization of hub protein DYNLL1 and bZIP transcription factor CREB3L1 enhances transcriptional activation of CREB3L1 target genes like arginine vasopressin
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    sciencedirect.com/science/article/pii/S0196978124001220
  9. www.cell.com www.cell.com
    Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities
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      DOI: 10.1016/j.neuron.2024.06.013

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    cell.com/neuron/abstract/S0896-6273(24)00448-3
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    The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation
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    sciencedirect.com/science/article/pii/S245194562400223X
  11. Jun 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation
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    1. scibot 21 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
  13. May 2024
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    Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism
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    sciencedirect.com/science/article/pii/S1097276524003290
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    Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists
    1
    1. scibot 01 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11042255/
  16. Apr 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans
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    sciencedirect.com/science/article/pii/S1534580724002302
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    Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line
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    1. scibot 13 Apr 2024
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      DOI: 10.1093/cercor/bhae136

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    ncbi.nlm.nih.gov/pmc/articles/PMC11008688/
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    Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors
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  20. Mar 2024
  21. www.biorxiv.org www.biorxiv.org
    PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
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    1. scibot 21 Mar 2024
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    biorxiv.org/content/10.1101/2024.03.03.583221v1
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    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
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  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pip5k1γ regulates axon formation by limiting Rap1 activity
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      DOI: 10.26508/lsa.202302383

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    ncbi.nlm.nih.gov/pmc/articles/PMC10912816/
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    Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease
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    sciencedirect.com/science/article/pii/S1097276524001254
  25. Feb 2024
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    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
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    sciencedirect.com/science/article/pii/S2211124724001736
  27. 52.53.155.43 52.53.155.43
    Regulation of the intestinal Na+/H+ exchanger NHE3 by AMP-activated kinase is dependent on phosphorylation of NHE3 at S555 and S563
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    52.53.155.43/f69a85cf28386bd1400aa251e3a5d55dee473eb1/han-et-al-2024-regulation-of-the-intestinal-na-h-exchanger-nhe3-by-amp-activated-kinase-is-dependent-on-phosphorylation-html.html
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    C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830871/
  30. Dec 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics
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    sciencedirect.com/science/article/pii/S2451945623004257
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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  33. Oct 2023
  34. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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      DOI: 10.15252/embr.202356815

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  35. 52.53.155.43 52.53.155.43
    PIIS0092867423009650-html.html
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  36. Sep 2023
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    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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      DOI: 10.1016/j.chom.2023.08.003

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    sciencedirect.com/science/article/pii/S1931312823003281
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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    Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
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      DOI: 10.1101/2023.09.25.559255

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    biorxiv.org/content/10.1101/2023.09.25.559255v1
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    Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion
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    sciencedirect.com/science/article/pii/S2211124723010537
  41. Aug 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability. 5-HT receptor cross-talks shape 5-HT neuron activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10415917/
  43. Jul 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Structural basis for membrane-proximal proteolysis of substrates by ADAM10
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      DOI: 10.1016/j.cell.2023.06.026

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    sciencedirect.com/science/article/abs/pii/S009286742300733X
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    sciencedirect.com/science/article/pii/S2211124723008124
  46. Jun 2023
  47. www.sciencedirect.com www.sciencedirect.com
    A mitochondrial iron-responsive pathway regulated by DELE1
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      DOI: 10.1016/j.molcel.2023.05.031

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    sciencedirect.com/science/article/pii/S1097276523004136
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    NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs
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  49. May 2023
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    Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
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      DOI: 10.1016/j.molcel.2023.04.021

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    sciencedirect.com/science/article/pii/S1097276523002927
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    The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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  107. Aug 2021
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    Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells
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  128. Mar 2021
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    DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
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    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
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    Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling
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  153. Jan 2020
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    Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains
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    The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing
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  157. onlinelibrary.wiley.com onlinelibrary.wiley.com
    C2‐lacking isoform of Nedd4‐2 regulates excitatory synaptic strength through GluA1 ubiquitination‐independent mechanisms
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      DOI: 10.1111/jnc.14840

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  158. www.sciencedirect.com www.sciencedirect.com
    Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
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      DOI: 10.1016/j.molcel.2019.10.019

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  159. elifesciences.org elifesciences.org
    The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila
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  160. www.sciencedirect.com www.sciencedirect.com
    Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder
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    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
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  162. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Lack of PDZD7 long isoform disrupts ankle‐link complex and causes hearing loss in mice
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      DOI: 10.1096/fj.201901657RR

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  163. cancerres.aacrjournals.org cancerres.aacrjournals.org
    Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition
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      DOI: 10.1158/0008-5472.CAN-18-1888

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  164. www.sciencedirect.com www.sciencedirect.com
    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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  165. www.sciencedirect.com www.sciencedirect.com
    Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration
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      DOI: 10.1016/j.neuron.2019.10.009

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  166. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.molcel.2018.12.010

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  169. www.sciencedirect.com www.sciencedirect.com
    LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis
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      DOI: 10.1016/j.ebiom.2018.12.056

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  170. Nov 2018
  171. www.sciencedirect.com www.sciencedirect.com
    GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing
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  172. www.sciencedirect.com www.sciencedirect.com
    Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens
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  173. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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    BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
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    Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture
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    Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair
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    SHRED Is a Regulatory Cascade that Reprograms Ubr1 Substrate Specificity for Enhanced Protein Quality Control during Stress
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein
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  180. www.sciencedirect.com www.sciencedirect.com
    Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
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    Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
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    Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy
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    As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
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    NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis
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  185. Nov 2017
  186. www.sciencedirect.com www.sciencedirect.com
    ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer
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  187. www.sciencedirect.com www.sciencedirect.com
    Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles
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  188. www.sciencedirect.com www.sciencedirect.com
    Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination
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  189. www.sciencedirect.com www.sciencedirect.com
    A Two-Immunoglobulin-Domain Transmembrane Protein Mediates an Epidermal-Neuronal Interaction to Maintain Synapse Density
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