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TM6SF2 acts at ER membrane contact sites to enable RAB7-dependent endolysosomal VLDL secretion and maintain Golgi structure

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1. scibot 17 Oct 2026
  
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  DOI: 10.1016/j.celrep.2026.118116
  
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Oct 2026
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A high-confidence inventory of the proteins in the mitochondrion-related organelle of Giardia

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1. scibot 03 Oct 2026
  
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  DOI: 10.1016/j.cub.2026.07.074
  
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MCUB restricts mitochondrial calcium to support metabolic adaptation and homeostasis in glioblastoma

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1. scibot 01 Oct 2026
  
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  DOI: 10.1016/j.celrep.2026.118036
  
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Sep 2026
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Cell volume regulation in metazoans involves phosphorylation of TSC22D proteins

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1. scibot 29 Sep 2026
  
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A bacterial effector triggers dual-layer plant immunity through interaction with cell-surface and intracellular proteins

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1. scibot 26 Sep 2026
  
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Jul 2026
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Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer

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1. scibot 23 Jul 2026
  
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Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development

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1. scibot 23 Jul 2026
  
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Asperous coordinates regeneration timing by regulating damage-induced WNT signaling

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1. scibot 17 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116823
  
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Jun 2026
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Quantitative profiling of RNA modifications enriched in non-membrane-bound cellular structures using APEX-RNA-MS

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1. scibot 25 Jun 2026
  
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sciencedirect.com/science/article/pii/S2451945626001911
May 2026
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RpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition

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1. scibot 27 May 2026
  
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Essential lncRNAs in the human transcriptome

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1. scibot 19 May 2026
  
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  DOI: 10.1016/j.xgen.2026.101253
  
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Apr 2026
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Cav3.1 is a neuronal leucine sensor that mediates satiety and weight loss in response to dietary protein

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1. scibot 24 Apr 2026
  
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CryAB-driven amyloidogenesis in Drosophila muscle engages extracellular vesicle pathways for cellular release

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1. scibot 21 Apr 2026
  
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  DOI: 10.1016/j.isci.2026.115461
  
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The KIF3B/B/KAP3 tail domain specifically facilitates TRIM46 transport to the axon initial segment

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1. scibot 03 Apr 2026
  
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  DOI: 10.1083/jcb.202503138
  
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Human promoter-driven AAV tools enable precision gene therapy targeting cochlear hair cells

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sciencedirect.com/science/article/pii/S2666379126001424
Mar 2026
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Identification and characterization of BRAF⇔TP53 interactions in melanoma

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1. scibot 24 Mar 2026
  
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Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

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Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells

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1. scibot 04 Mar 2026
  
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  DOI: 10.1016/j.chembiol.2023.02.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10069010/
Feb 2026
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Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism

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1. scibot 24 Feb 2026
  
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  DOI: 10.1038/s41467-022-30178-x
  
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Dual roles of USP39 in stabilizing PB2 and orchestrating ribonucleoprotein assembly drive H5 influenza virus replication and pathogenicity

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Jan 2026
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MITF, TFEB, and TFE3 drive distinct adaptive gene expression programs and immune infiltration in melanoma

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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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KDM7B-mediated demethylation of RNF113A regulates small cell lung cancer sensitivity to alkylation damage

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  DOI: 10.64898/2026.01.03.697470
  
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Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer

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Dec 2025
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Mitochondrial VHL rewires cell metabolism in hypoxia

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The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis

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Functional Domain Mapping of TPO: Insights from Six Variants in Sudanese Kindreds with Congenital Hypothyroidism

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  DOI: 10.1210/clinem/dgaf536
  
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Nov 2025
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RhoA allosterically activates phospholipase Cε via its EF hands

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A genetic circuit that extends the useful range of a BMP morphogen arose alongside insect wing evolution

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Control of aging-associated neurodegeneration via hypothalamic extracellular vesicles containing parathymosin

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Oct 2025
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Cryo-EM structure of phospholipase Cε defines N-terminal domains and their roles in activity

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  DOI: 10.1038/s42003-025-08831-0
  
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1-s2.0-S258900422501987X-main-html.html

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DUSP14 suppresses ferroptosis and promotes tumor progression of triple-negative breast cancer

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Sep 2025
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IFT88-KAP interaction defines a conserved mechanism for kinesin-2-IFT coupling

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  DOI: 10.1016/j.cub.2025.08.056
  
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Dual AAV vectors for efficient delivery of large transgenes

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  DOI: 10.1038/s41596-025-01243-8
  
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Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

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Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila

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KDM5-mediated activation of genes required for mitochondrial biology is necessary for viability in Drosophila

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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity

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Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain

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RAF1 kinase contributes to autophagic lysosome reformation

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ioaf076-html.html

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YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells

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Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

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Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass

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Novel Pannexin 1 isoform is increased in cancer

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PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer

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ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

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Anticancer effect of a single-chain variable fragment against pro-matrix metalloproteinase-7 in colon cancer

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Functional specialization of MITF, TFEB and TFE3 drives radically distinct adaptive gene expression programs in melanoma

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Modelling quiescence exit of neural stem cells reveals a FOXG1-FOXO6 axis

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Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes

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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

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Reduced mesencephalic astrocyte-derived neurotrophic factor ... : Neural Regeneration Research

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BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination

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Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity

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Mechanism of barotaxis in marine zooplankton

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Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function

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TGF-β and RAS jointly unmask primed enhancers to drive metastasis

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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

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The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction

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High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila

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Dimerization of hub protein DYNLL1 and bZIP transcription factor CREB3L1 enhances transcriptional activation of CREB3L1 target genes like arginine vasopressin

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Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities

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The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation

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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

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Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

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Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

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Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans

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Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line

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Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors

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PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer

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Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1

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Pip5k1γ regulates axon formation by limiting Rap1 activity

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Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease

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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

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Regulation of the intestinal Na+/H+ exchanger NHE3 by AMP-activated kinase is dependent on phosphorylation of NHE3 at S555 and S563

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C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line

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Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

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Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics

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Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway

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The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes

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PIIS0092867423009650-html.html

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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

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Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells

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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

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5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability. 5-HT receptor cross-talks shape 5-HT neuron activity

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Structural basis for membrane-proximal proteolysis of substrates by ADAM10

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Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis

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A mitochondrial iron-responsive pathway regulated by DELE1

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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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Unconventional initiation of PINK1/Parkin mitophagy by Optineurin

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The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

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Proteomic discovery of chemical probes that perturb protein complexes in human cells

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Transcriptional kinetic synergy: A complex landscape revealed by integrating modeling and synthetic biology

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DTX3L E3 ligase targets p53 for degradation at poly ADP-ribose polymerase-associated DNA damage sites

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VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

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The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells

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Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells

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Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5

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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

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A novel period mutation implicating nuclear export in temperature compensation of the Drosophila circadian clock

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An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes

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MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor

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Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy

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In situ cell-type-specific cell-surface proteomic profiling in mice

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Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication

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RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss

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Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2

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Rapid macropinocytic transfer of α-synuclein to lysosomes

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Control of coronary vascular resistance by eicosanoids via a novel GPCR

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Transcriptional reprogramming differentiates active from inactive ESR1 fusions in endocrine therapy-refractory metastatic breast cancer

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Control of coronary vascular resistance by eicosanoids via a novel GPCR

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Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

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Study of novel NARS2 variants in patient of combined oxidative phosphorylation deficiency 24

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CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

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Spatial CRISPR genomics identifies regulators of the tumor microenvironment

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The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function

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Regulation of GTPase function by autophosphorylation

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Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination

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ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points

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Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

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Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes

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Sparse dictionary learning recovers pleiotropy from human cell fitness screens

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Subcellular and regional localization of mRNA translation in midbrain dopamine neurons

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The balance of mitochondrial fission and fusion in cortical axons depends on the kinases SadA and SadB

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BPS Publications

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Molecular and functional architecture of striatal dopamine release sites

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Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

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TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

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IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

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SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir

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TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.

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Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation

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LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes

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CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells

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Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

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PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

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Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells

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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

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A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation

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DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1

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Evasion of type-I interferon by SARS-CoV-2

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The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction

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Translation in amino-acid-poor environments is limited by tRNAGln charging

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Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε

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BPS Publications

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An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

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Evasion of type-I interferon by SARS-CoV-2

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Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

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Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription

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BRCA1 Mutational Complementation Induces Synthetic Viability

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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel

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The RNFT2/IL3Rα axis regulates IL3 signaling and innate immunity

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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

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Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne

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Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains

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KIAA0317 regulates pulmonary inflammation through SOCS2 degradation

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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

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C2‐lacking isoform of Nedd4‐2 regulates excitatory synaptic strength through GluA1 ubiquitination‐independent mechanisms

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Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB

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The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

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Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder

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Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

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Lack of PDZD7 long isoform disrupts ankle‐link complex and causes hearing loss in mice

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Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration

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Untitled document

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Untitled document

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Untitled document

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LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis

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GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing

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Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens

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Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response

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BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

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Mechanotransduction by PCDH15 Relies on a Novel cis-Dimeric Architecture

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Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair

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