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Jul 2025
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Spironolactone Partially Reverses Autism-Like Behaviors Linked to ErbB4 and mTOR Phosphorylation in the Mouse Prefrontal Cortex and Striatum

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  DOI: 10.1016/j.arcmed.2025.103254
  
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sciencedirect.com/science/article/pii/S0188440925000748
alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com

Interconnections of insulin/IGF-1 signaling and autophagy abnormalities in Alzheimer's disease

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  DOI: 10.1002/alz.70099
  
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alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70099
Jun 2025
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PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.envpol.2024.123674
  
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sciencedirect.com/science/article/pii/S0269749124003889
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ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115851
  
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sciencedirect.com/science/article/pii/S2211124725006229
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In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells

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  DOI: 10.1177/15347354251344592
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12141803/
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In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells

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  DOI: 10.1177/15347354251344592
  
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journals.sagepub.com/doi/full/10.1177/15347354251344592
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The Effect of FPR2 on the Regulation of Trophoblast Autophagy via the PI3K/AKT/mTOR Signaling Pathway in Preeclampsia

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1. scibot 11 Jun 2025
  
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  DOI: 10.1096/fj.202402938RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202402938RR
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The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.022
  
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sciencedirect.com/science/article/pii/S1097276525004617
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Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy

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1. scibot 03 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.006
  
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sciencedirect.com/science/article/pii/S1074761325002274
May 2025
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Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.devcel.2025.04.027
  
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration | Molecular Biology of the Cell

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1. scibot 19 May 2025
  
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  DOI: 10.1091/mbc.E24-11-0512
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11974963/
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1-s2.0-S2589004225007874-main-html.html

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112526
  
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Stromal lipid species dictate melanoma metastasis and tropism

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.001
  
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sciencedirect.com/science/article/pii/S1535610825001382
Apr 2025
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PDF-html.html

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  DOI: 10.5281/zenodo.15149909
  
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52.53.155.43/b645d57731bbad4da56bb2d7f98fed3df22d621f/PDF-html.html
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Time Release Ion Matrix Regenerates Dystrophic Skeletal Muscle

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1. scibot 19 Apr 2025
  
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  DOI: 10.21203/rs.3.rs-5968078/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957216/
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1-s2.0-S2212877825000584-main-html.html

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.molmet.2025.102151
  
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52.53.155.43/284b8517565b9764dbe5c0470f72829f488a110b/1-s2.0-S2212877825000584-main-html.html
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Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy

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1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.03.003
  
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sciencedirect.com/science/article/pii/S1550413125001068
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PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

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1. scibot 08 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115541
  
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sciencedirect.com/science/article/pii/S2211124725003122
Mar 2025
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The compound... : Neural Regeneration Research

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  DOI: 10.4103/NRR.NRR-D-23-01890
  
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journals.lww.com/nrronline/fulltext/2025/11000/the_compound.34.aspx
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A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans

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  DOI: 10.1016/j.xgen.2025.100782
  
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KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids

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  DOI: 10.1016/j.neuron.2025.02.001
  
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Feb 2025
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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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1. scibot 14 Feb 2025
  
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  DOI: 10.1158/2159-8290.CD-21-1022
  
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aacrjournals.org/cancerdiscovery/article/12/7/1718/705192/IFN-Potentiates-Anti-PD-1-Efficacy-by-Remodeling
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Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1535-7163.MCT-21-0848
  
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aacrjournals.org/mct/article/21/7/1160/705294/Peptide-PDHPS1-Inhibits-Ovarian-Cancer-Growth
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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  DOI: 10.1038/s41467-025-56564-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
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The coagulation and tumor system are directly linked through the proteolysis and activation of epidermal growth factor receptor by thrombin

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  DOI: 10.1038/s41388-025-03296-1
  
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2. scibot 06 Feb 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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nature.com/articles/s41388-025-03296-1
Jan 2025
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Repeated sevoflurane exposure causes hypomyelination in the prefrontal cortex of adult male mice

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  DOI: 10.1038/s41598-025-85834-1
  
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Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding

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  DOI: 10.1016/j.ccell.2024.12.006
  
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Dec 2024
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Maternal gut microbiota influence stem cell function in offspring

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  DOI: 10.1016/j.stem.2024.10.003
  
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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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  DOI: 10.1016/j.cell.2024.11.009
  
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Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery

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  DOI: 10.1016/j.stem.2024.10.015
  
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sciencedirect.com/science/article/pii/S1934590924003771
Nov 2024
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Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

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1. scibot 10 Nov 2024
  
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  DOI: 10.7554/eLife.97854
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11542922/
Oct 2024
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

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1. scibot 05 Oct 2024
  
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  DOI: 10.1101/2024.09.09.612106
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
Aug 2024
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Acetate enables metabolic fitness and cognitive performance during sleep disruption

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  DOI: 10.1016/j.cmet.2024.07.019
  
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sciencedirect.com/science/article/pii/S1550413124002900
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Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.cell.2020.02.019
  
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Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation

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Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma

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Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice

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Canagliflozin Attenuates Post-Resuscitation Myocardial Dysfunction in Diabetic Rats by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway

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PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1

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Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling

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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

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Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

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BPS Publications

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Adiponectin inhibits the progression of obesity-associated papillary thyroid carcinoma through autophagy

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2024.02.09.579580v1.full-html.html

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Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy

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BPS Publications

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Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma

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Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation

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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

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Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy

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Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome

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CircTBC1D22A inhibits the progression of colorectal cancer through autophagy regulated via miR-1825/ATG14 axis

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Trichinella spiralis inhibits myoblast differentiation by targeting SQSTM1/p62 with a secreted E3 ubiquitin ligase

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BPS Publications

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Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice

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EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis

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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

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Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling

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Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation

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Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival

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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model

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KDM5B predicts temozolomide-resistant subclones in glioblastoma

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Lysosomal dynamics regulate mammalian cortical neurogenesis

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Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions

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Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

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Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway

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A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer

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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

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N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes

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Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice

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Aggravated hepatic fibrosis induced by phenylalanine and tyrosine was ameliorated by chitooligosaccharides supplementation

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PIIS2589004223017029-html.html

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Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

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BPS Publications

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Bexarotene improves motor function after spinal cord injury in mice

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GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells

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ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

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Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice

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ECPAS/Ecm29-mediated 26S proteasome disassembly is an adaptive response to glucose starvation

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The potential therapeutic regimen for overcoming resistance to osimertinib due to rare mutations in NSCLC

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Acetate controls endothelial-to-mesenchymal transition

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MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells

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Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA

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Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling

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ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL

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MTHFD2 reprograms macrophage polarization by inhibiting PTEN

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A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation

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eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

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Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment

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A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation

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KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells

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Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

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Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity

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FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression

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mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system

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HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease

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Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma

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AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance

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Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways

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GABA regulates IL-1β production in macrophages

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Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies

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Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

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Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter

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Multiplexed protein profiling reveals spatial subcellular signaling networks

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Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation

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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

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Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis

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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines

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Phloretin enhances autophagy by impairing AKT activation and inducing JNK-Beclin-1 pathway activation

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GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

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Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

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cd-21-1022-html.html

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mct-21-0848-html.html

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Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

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Intermittent Theta Burst Stimulation Ameliorates Cognitive Deficit and Attenuates Neuroinflammation via PI3K/Akt/mTOR Signaling Pathway in Alzheimer’s-Like Disease Model

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Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control

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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

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L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy

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Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma

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The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice

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Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

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Nicotinamide Breaks Effector CD8 T cell Responses by Targeting mTOR Signaling

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Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways

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Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

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Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism

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C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis

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Translational and post-translational control of human naïve versus primed pluripotency

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BPS Publications

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BPS Publications

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TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models

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Chronic calcium signaling in IgE+ B cells limits plasma cell differentiation and survival

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GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

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Disrupting phosphorylation of Tyr-1070 at GluN2B selectively produces resilience to depression-like behaviors

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Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer

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Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

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Sequential oncogenic mutations influence cell competition

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An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

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Neuronal activity recruits the CRTC1/CREB axis to drive transcription-dependent autophagy for maintaining late-phase LTD

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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock

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Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway

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Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK

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Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways

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Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies

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An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors

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Novel guanidine compounds inhibit platelet‐derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation

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Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

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JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding

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A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

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Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States

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Metabolic Control over mTOR-Dependent Diapause-like State

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Environmental arginine controls multinuclear giant cell metabolism and formation

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The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy

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Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression

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Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice

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Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR

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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation

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Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

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Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice

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A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

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BPS Publications

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New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

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