184 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Maternal gut microbiota influence stem cell function in offspring
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    sciencedirect.com/science/article/pii/S1934590924003655
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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    sciencedirect.com/science/article/pii/S0092867424013266
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    Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
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      DOI: 10.1016/j.stem.2024.10.015

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  5. Nov 2024
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
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      DOI: 10.7554/eLife.97854

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  7. Oct 2024
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    Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
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  9. Aug 2024
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    Acetate enables metabolic fitness and cognitive performance during sleep disruption
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
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    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
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    sciencedirect.com/science/article/pii/S0303720724001977
  13. cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com
    Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma
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  14. Jul 2024
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    Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice
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    sciencedirect.com/science/article/pii/S2090123224003096
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    Canagliflozin Attenuates Post-Resuscitation Myocardial Dysfunction in Diabetic Rats by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway
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    PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
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    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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  19. Jun 2024
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    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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  22. May 2024
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16420
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    Adiponectin inhibits the progression of obesity-associated papillary thyroid carcinoma through autophagy
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  25. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
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    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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  28. www.cell.com www.cell.com
    Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00188-5
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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      DOI: 10.21203/rs.3.rs-4114038/v1

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  30. Apr 2024
  31. www.sciencedirect.com www.sciencedirect.com
    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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      DOI: 10.1016/j.immuni.2024.03.021

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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    sciencedirect.com/science/article/pii/S2352396424001348
  34. Mar 2024
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CircTBC1D22A inhibits the progression of colorectal cancer through autophagy regulated via miR-1825/ATG14 axis
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  37. Feb 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Trichinella spiralis inhibits myoblast differentiation by targeting SQSTM1/p62 with a secreted E3 ubiquitin ligase
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      DOI: 10.1111/bph.16283

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16283
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    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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      DOI: 10.3233/JAD-221058

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    content.iospress.com/articles/journal-of-alzheimers-disease/jad221058
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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  43. Jan 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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      DOI: 10.1126/sciadv.adi2012

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
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    Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation
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    Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival
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    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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  148. Oct 2021
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  150. Aug 2021
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    Disrupting phosphorylation of Tyr-1070 at GluN2B selectively produces resilience to depression-like behaviors
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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  158. Jul 2021
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  165. Jun 2021
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    Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway
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  167. May 2021
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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  181. Sep 2020
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      p-mTOR Ser2448

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    The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy
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  189. Jan 2020
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    Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression
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    Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice
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    Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR
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    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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    Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming
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    Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    Exogenous H2S exerts biphasic effects on porcine mammary epithelial cells proliferation through PI3K/Akt‐mTOR signaling pathway
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase
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    Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
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    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
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    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
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