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Biobank of genetically defined murine prostate cancer tumoroids uncovers oncogenic pathways and drug vulnerabilities driven by PTEN-loss

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pmc.ncbi.nlm.nih.gov/articles/PMC13106976/
Mar 2026
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OGDHL promotes prostate cancer progression and regulates neuroendocrine marker expression and nucleotide abundance

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pmc.ncbi.nlm.nih.gov/articles/PMC12949684/
Feb 2026
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The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12900249/
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ZNF711 promotes enzalutamide resistance through transcriptional and epigenetic modification of the androgen receptor signaling pathway

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  DOI: 10.1007/s00018-026-06092-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12891305/
Jan 2026
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Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer

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1. scibot 13 Jan 2026
  
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academic.oup.com/endo/article/167/1/bqaf168/8320418
Oct 2025
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Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis

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1. scibot 17 Oct 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1904
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12498101/
Jun 2025
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52.53.155.43/fedd6ccff8c0b6494dbe8595a0c800e33e0860f7/PDF-html.html
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BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115779
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00550-9
Mar 2025
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Small-molecule RNA therapeutics to target prostate cancer

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cell.com/cancer-cell/abstract/S1535-6108(25)00079-0
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
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CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer

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1. scibot 21 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115312
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00083-X
Jan 2025
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An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer

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1. scibot 25 Jan 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11733533/
Sep 2024
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MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer

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1. scibot 18 Sep 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398899/
Feb 2024
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An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer

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1. scibot 28 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108794
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10879682/
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Stromal-derived MAOB promotes prostate cancer growth and progression

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1. scibot 14 Feb 2024
  
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  DOI: 10.1126/sciadv.adi4935
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857382/
Jan 2024
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TNIK drives Castration-Resistant Prostate Cancer via phosphorylating EGFR

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1. scibot 18 Jan 2024
  
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  DOI: 10.1016/j.isci.2023.108713
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10788198/
Dec 2023
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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113564
  
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sciencedirect.com/science/article/pii/S2211124723015760
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MYB exhibits racially disparate expression, clinicopathologic association, and predictive potential for biochemical recurrence in prostate cancer

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108487
  
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sciencedirect.com/science/article/pii/S2589004223025646
Oct 2023
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MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer

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  DOI: 10.1016/j.celrep.2023.113221
  
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sciencedirect.com/science/article/pii/S2211124723012330
Sep 2023
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Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate

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1. scibot 30 Sep 2023
  
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sciencedirect.com/science/article/pii/S2589004223020412
Aug 2023
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ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer

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52.53.155.43/5c44b570825d260ed49e3beddaa9d47779a57883/PIIS2211124723009488-html.html
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Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

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ncbi.nlm.nih.gov/pmc/articles/PMC10433013/
Jul 2023
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Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

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1. scibot 21 Jul 2023
  
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sciencedirect.com/science/article/pii/S1535610823002350
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Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery

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Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer

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sciencedirect.com/science/article/pii/S2211124723008094
Jun 2023
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Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer

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ncbi.nlm.nih.gov/pmc/articles/PMC10261916/
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The Transmembrane Protein TM4SF3 Interacts with AR and AR-V7 and is Recruited to AR Target Genes

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1. scibot 02 Jun 2023
  
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  DOI: 10.1210/endocr/bqad048
  
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academic.oup.com/endo/article/164/5/bqad048/7084716
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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

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sciencedirect.com/science/article/pii/S0092867423005226
May 2023
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Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer

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1. scibot 27 May 2023
  
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  DOI: 10.1016/j.canlet.2023.216244
  
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sciencedirect.com/science/article/pii/S0304383523001957
Apr 2023
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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer

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  DOI: 10.1016/j.xcrm.2023.101015
  
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sciencedirect.com/science/article/pii/S2666379123001258
Mar 2023
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Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers

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  DOI: 10.1016/j.xcrm.2023.100977
  
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sciencedirect.com/science/article/pii/S2666379123000836
Feb 2023
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Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

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1. scibot 10 Feb 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-1533
  
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aacrjournals.org/cancerres/article/83/2/219/715076/Plk1-Inhibitors-and-Abiraterone-Synergistically
Dec 2022
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Dual Acting Peptides Target EZH2 and AR: a New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer

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1. scibot 03 Dec 2022
  
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  DOI: 10.1210/endocr/bqac180
  
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academic.oup.com/endo/article/164/1/bqac180/6775160
Nov 2022
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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

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  DOI: 10.1016/j.ccell.2022.10.021
  
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Oct 2022
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GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

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  DOI: 10.7554/eLife.81083
  
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Aug 2022
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Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer

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  DOI: 10.1158/1078-0432.CCR-22-0851
  
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Jul 2022
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A specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand

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Jun 2022
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Evidence that HDAC7 acts as an epigenetic “reader” of AR acetylation through NCoR-HDAC3 dissociation

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  DOI: 10.1016/j.chembiol.2022.05.008
  
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May 2022
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A human breast atlas integrating single-cell proteomics and transcriptomics

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1. scibot 26 May 2022
  
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  DOI: 10.1016/j.devcel.2022.05.003
  
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Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer

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  DOI: 10.1016/j.xcrm.2022.100604
  
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Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids

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Inhibiting 3βHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer

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Feb 2022
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A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer

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Bidirectional Crosstalk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer

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Aug 2021
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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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Jul 2021
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CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer

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Apr 2021
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Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation

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  DOI: 10.1210/jendso/bvab035
  
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Feb 2021
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A modular master regulator landscape controls cancer transcriptional identity

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Selective targeting of the androgen receptor-DNA binding domain by the novel antiandrogen SBF-1 and inhibition of the growth of prostate cancer cells

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  DOI: 10.1007/s10637-020-01050-w
  
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Sep 2020
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Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress

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Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

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  DOI: 10.1111/bph.14657
  
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Jan 2020
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The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

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Untitled document

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ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer

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