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SMAD4 loss drives cancer chromosomal instability through transcription-replication conflict-induced replication stress

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1. scibot 25 Jun 2026
  
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  DOI: 10.64898/2025.12.17.694873
  
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biorxiv.org/content/10.64898/2025.12.17.694873v1
Jun 2026
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hSpindly dynamics modulate spindle assembly checkpoint signaling, promoting resistance to mitotic inhibitors

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  DOI: 10.1016/j.isci.2026.116312
  
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sciencedirect.com/science/article/pii/S2589004226016871
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Single kinetochores execute an ordered series of molecular events as the spindle assembly checkpoint is silenced

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1. scibot 04 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117493
  
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sciencedirect.com/science/article/pii/S2211124726005711
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Proximity-based activation of AURORA A by MPS1 potentiates error correction

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1. scibot 22 Apr 2026
  
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  DOI: 10.1016/j.cub.2025.03.018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12014372/
Mar 2026
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Multi-omic analyses reveal a differential contribution of chromatin-associated PP1 holoenzymes to mitotic exit and G1 re-establishment

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.devcel.2026.02.016
  
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sciencedirect.com/science/article/pii/S153458072600081X
Feb 2026
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2026.01.30.702807v1.full-html.html

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  DOI: 10.64898/2026.01.30.702807
  
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54.241.53.176/a1fb126143f6ebd2aa86840167c32224c61cfe36/2026.01.30.702807v1.full-html.html
Oct 2025
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Chromatin remodeling activity of EP400 safeguards chromosomal stability by preventing CENP-A mislocalization

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116423
  
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sciencedirect.com/science/article/pii/S2211124725011945
Sep 2025
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A pivot-tether model for nucleosome recognition by the chromosomal passenger complex

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1. scibot 20 Sep 2025
  
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  DOI: 10.1038/s44319-025-00523-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12420818/
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Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer

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1. scibot 07 Sep 2025
  
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  DOI: 10.26508/lsa.202503295
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12373720/
Aug 2025
52.53.155.43 52.53.155.43

2025.08.20.671312v1.full-html.html

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1. scibot 27 Aug 2025
  
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  DOI: 10.1101/2025.08.20.671312
  
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52.53.155.43/ddcc60ded97dfd48e5e43dd600e7d3e243ab588e/2025.08.20.671312v1.full-html.html
Dec 2024
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Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition

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1. scibot 21 Dec 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0408
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11586712/
Nov 2024
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Protocol for validating liquid-liquid phase separation as a driver of membraneless organelle assembly in vitro and in human cells

1
1. scibot 10 Nov 2024
  
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  DOI: 10.1016/j.xpro.2024.103410
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11541453/
May 2024
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Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.cell.2024.04.014
  
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sciencedirect.com/science/article/pii/S0092867424004094
Apr 2024
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localization

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1. scibot 16 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.03.022
  
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sciencedirect.com/science/article/pii/S1097276524002673
Feb 2024
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Specialized replication mechanisms maintain genome stability at human centromeres

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1. scibot 15 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.01.018
  
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2. scibot 15 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.01.018
  
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sciencedirect.com/science/article/pii/S1097276524000546
Dec 2023
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Age-dependent loss of cohesion protection in human oocytes

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.cub.2023.11.061
  
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sciencedirect.com/science/article/pii/S0960982223016494
Nov 2023
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Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation

1
1. scibot 10 Nov 2023
  
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  DOI: 10.1038/s41467-023-43115-3
  
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nature.com/articles/s41467-023-43115-3
Aug 2023
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Senescent cells form nuclear foci that contain the 26S proteasome

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  DOI: 10.1016/j.celrep.2023.112880
  
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sciencedirect.com/science/article/pii/S2211124723008914
May 2023
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Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.

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  DOI: 10.1016/j.isci.2023.106743
  
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sciencedirect.com/science/article/pii/S2589004223008209
Apr 2023
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Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation

1
1. scibot 13 Apr 2023
  
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  DOI: 10.1101/2023.02.28.530230
  
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52.53.155.43/21d7e0de21d77b609c83e3b4525fe6d90ea7288a/2023.02.28.530230v1.full-html.html
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ERCC6L2 mitigates replication stress and promotes centromere stability

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  DOI: 10.1016/j.celrep.2023.112329
  
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sciencedirect.com/science/article/pii/S2211124723003406
Feb 2023
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Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression

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1. scibot 09 Feb 2023
  
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  DOI: 10.1016/j.cub.2023.01.010
  
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sciencedirect.com/science/article/pii/S0960982223000106
Dec 2022
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Increased replication origin firing links replication stress to whole chromosomal instability in human cancer

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1. scibot 18 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111836
  
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sciencedirect.com/science/article/pii/S2211124722017284
Nov 2022
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MPS1 localizes to end-on microtubule-attached kinetochores to promote microtubule release

1
1. scibot 17 Nov 2022
  
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  DOI: 10.1016/j.cub.2022.10.047
  
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sciencedirect.com/science/article/pii/S0960982222016955
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LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly

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1. scibot 04 Nov 2022
  
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  DOI: 10.1016/j.molcel.2022.09.022
  
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sciencedirect.com/science/article/pii/S109727652200911X
Oct 2022
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Off-the-shelf proximity biotinylation using ProtA-TurboID

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1. scibot 14 Oct 2022
  
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  DOI: 10.1038/s41596-022-00748-w
  
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nature.com/articles/s41596-022-00748-w
Sep 2022
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Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells

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  DOI: 10.1016/j.cub.2022.08.026
  
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sciencedirect.com/science/article/pii/S0960982222013033
Mar 2022
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CENP-B-mediated DNA loops regulate activity and stability of human centromeres

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1. scibot 26 Mar 2022
  
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sciencedirect.com/science/article/pii/S1097276522002064
Nov 2021
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Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.devcel.2021.10.007
  
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sciencedirect.com/science/article/pii/S153458072100808X
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The Aurora B gradient sustains kinetochore stability in anaphase

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109818
  
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sciencedirect.com/science/article/pii/S2211124721012821
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Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub

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1. scibot 03 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109924
  
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sciencedirect.com/science/article/pii/S2211124721013978
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 07 Aug 2021
  
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  DOI: 10.1016/j.cub.2018.08.056
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6224608/
Nov 2020
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BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment

1
1. scibot 24 Nov 2020
  
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  DOI: 10.1016/j.celrep.2020.108397
  
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  RRID:AB_10693556 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720313863
Sep 2020
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Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

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1. scibot 17 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107533
  
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A Biosensor for the Mitotic Kinase MPS1 Reveals Spatiotemporal Activity Dynamics and Regulation

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  DOI: 10.1016/j.cub.2020.07.062
  
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Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors

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  DOI: 10.1016/j.celrep.2020.107535
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.017
  
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Nov 2018
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Untitled document

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1. scibot 05 Nov 2018
  
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Untitled document

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Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

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1. scibot 05 Nov 2018
  
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Distinct Roles of the Chromosomal Passenger Complex in the Detection of and Response to Errors in Kinetochore-Microtubule Attachment

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1. scibot 08 Nov 2017
  
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