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A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.chembiol.2025.08.004
  
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sciencedirect.com/science/article/pii/S2451945625002557
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Keratinocyte-derived VEGF-A is an essential pro-migratory autocrine mediator, acting through the KDR/GEF-H1/RhoA pathway

1
1. scibot 05 Aug 2025
  
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  AB_10693922
  
  DOI: 10.3389/fcell.2025.1601887
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12310649/
Jun 2025
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Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain

1
1. scibot 12 Jun 2025
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.isci.2025.112753
  
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sciencedirect.com/science/article/pii/S2589004225010144
Apr 2025
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Specific macrophage RhoA targeting CRISPR-Cas9 for mitigating osteoclastogenesis-induced joint damage in inflammatory arthritis

1
1. scibot 17 Apr 2025
  
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  DOI: 10.1016/j.xcrm.2025.102046
  
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sciencedirect.com/science/article/pii/S2666379125001193
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0442
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962402/
Feb 2025
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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

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1. scibot 28 Feb 2025
  
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  DOI: 10.1016/j.ccell.2025.02.001
  
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sciencedirect.com/science/article/pii/S1535610825000534
Dec 2024
www.cell.com www.cell.com

MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity

1
1. scibot 28 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115120
  
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cell.com/cell-reports/abstract/S2211-1247(24)01471-2
Sep 2024
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PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders

1
1. scibot 25 Sep 2024
  
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  AB_10693922
  
  DOI: 10.1016/j.cmet.2024.08.009
  
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sciencedirect.com/science/article/pii/S1550413124003619
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

1
1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.neuron.2024.06.002
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11377155/
Jun 2024
52.53.155.43 52.53.155.43

elife-92755-v2-html.html

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1. scibot 07 Jun 2024
  
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  AB_10693922
  
  DOI: 10.7554/elife.92755
  
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52.53.155.43/82e9bd136d23c9ba72ae36fc3bdfe32c939ebcb6/elife-92755-v2-html.html
May 2024
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Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts

1
1. scibot 23 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101576
  
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sciencedirect.com/science/article/pii/S2666379124002684
Apr 2024
52.53.155.43 52.53.155.43

elife-92755-v2-html.html

1
1. scibot 13 Apr 2024
  
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  AB_10693922
  
  DOI: 10.7554/elife.92755
  
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52.53.155.43/82e9bd136d23c9ba72ae36fc3bdfe32c939ebcb6/elife-92755-v2-html.html
Mar 2024
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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling

1
1. scibot 29 Mar 2024
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.chembiol.2024.02.013
  
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sciencedirect.com/science/article/pii/S2451945624000874
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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

1
1. scibot 22 Mar 2024
  
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  RRID:AB_10693922
  
  DOI: 10.7554/eLife.92755
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10950329/
Feb 2024
www.biorxiv.org www.biorxiv.org

Simulated Microgravity Enhances Adipocyte Maturation and Glucose Uptake via Increased Cortical Actin Remodeling

1
1. scibot 15 Feb 2024
  
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  RRID:AB_10693922
  
  DOI: 10.1101/2024.01.30.578049
  
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biorxiv.org/content/10.1101/2024.01.30.578049v1
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Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening

1
1. scibot 02 Feb 2024
  
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  RRID:AB_10693922
  
  DOI: 10.3390/antiox13020149
  
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mdpi.com/2076-3921/13/2/149
Nov 2023
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Unbiased interrogation of functional lysine residues in human proteome

1
1. scibot 28 Nov 2023
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.molcel.2023.10.033
  
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sciencedirect.com/science/article/pii/S1097276523008705
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The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin α6 mRNA splicing

1
1. scibot 03 Nov 2023
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.celrep.2023.113347
  
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sciencedirect.com/science/article/pii/S2211124723013591
Oct 2023
www.nature.com www.nature.com

RhoA balances microglial reactivity and survival during neuroinflammation

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1. scibot 21 Oct 2023
  
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  RRID:AB_10693922
  
  DOI: 10.1038/s41419-023-06217-w
  
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nature.com/articles/s41419-023-06217-w
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ZXDC Enhances Cervical Cancer Metastasis Through IGF2BP3-Mediated Activation of RhoA/ROCK Signaling

1
1. scibot 26 Aug 2023
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.isci.2023.107447
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10433122/
Nov 2022
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CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition

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1. scibot 16 Nov 2022
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.ccell.2022.10.015
  
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sciencedirect.com/science/article/pii/S1535610822005062
Jul 2022
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Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling

1
1. scibot 13 Jul 2022
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.celrep.2022.111072
  
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sciencedirect.com/science/article/pii/S2211124722008701
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Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover

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1. scibot 12 Jul 2022
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.devcel.2022.06.011
  
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sciencedirect.com/science/article/pii/S1534580722004518
May 2022
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The V2 receptor antagonist tolvaptan counteracts proliferation and invasivity in human cancer cells

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1. scibot 26 May 2022
  
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  RRID:AB_10693922
  
  DOI: 10.1007/s40618-022-01807-5
  
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link.springer.com/article/10.1007/s40618-022-01807-5
Mar 2022
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Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria

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1. scibot 26 Mar 2022
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.cub.2022.02.058
  
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sciencedirect.com/science/article/pii/S0960982222003281
Feb 2022
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Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction

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1. scibot 16 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110390
  
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sciencedirect.com/science/article/pii/S2211124722001115
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Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4

2
1. scibot 11 Feb 2022
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.chembiol.2022.01.007
  
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  DOI: 10.1016/j.chembiol.2022.01.007
  
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sciencedirect.com/science/article/pii/S2451945622000496
onlinelibrary.wiley.com onlinelibrary.wiley.com

ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12

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1. scibot 03 Feb 2022
  
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  DOI: 10.1002/ijc.33929
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.33929
Oct 2021
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Role of miR-185-5p as modulator of periostin synthesis and smooth muscle contraction in asthma

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1. scibot 30 Oct 2021
  
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  DOI: 10.1002/jcp.30620
  
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onlinelibrary.wiley.com/doi/10.1002/jcp.30620
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Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

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1. scibot 14 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109806
  
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sciencedirect.com/science/article/pii/S2211124721012663
Sep 2021
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KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

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1. scibot 22 Sep 2021
  
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  DOI: 10.1016/j.molcel.2021.09.001
  
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sciencedirect.com/science/article/pii/S1097276521007358
Aug 2021
www.nature.com www.nature.com

Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen

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1. scibot 17 Aug 2021
  
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  2117
  
  DOI: 10.1038/s41467-021-24968-y
  
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nature.com/articles/s41467-021-24968-y
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Untitled document

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1. scibot 13 Aug 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.devcel.2017.04.010
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5425256/
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Untitled document

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1. scibot 10 Aug 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.cmet.2018.11.017
  
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sciencedirect.com/science/article/pii/S1550413118307368
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1
1. scibot 07 Aug 2021
  
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  AB_10693922
  
  DOI: 10.7554/eLife.27444
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5745084/
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Untitled document

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1. scibot 05 Aug 2021
  
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  AB_10693922
  
  DOI: 10.7554/eLife.27444
  
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elifesciences.org/articles/27444
Jul 2021
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An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

2
1. scibot 29 Jul 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1186/s12915-018-0489-4
  
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2. scibot 27 Jul 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1186/s12915-018-0489-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5840776/
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RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6

2
1. scibot 28 Jul 2021
  
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  AB_10693922
  
  DOI: 10.1016/j.devcel.2017.04.010
  
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2. scibot 28 Jul 2021
  
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  AB_10693922
  
  DOI: 10.1016/j.devcel.2017.04.010
  
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sciencedirect.com/science/article/pii/S1534580717303039
Jun 2021
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Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis

1
1. scibot 02 Jun 2021
  
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  2117s
  
  DOI: 10.1016/j.canlet.2021.05.033
  
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sciencedirect.com/science/article/pii/S0304383521002573
May 2021
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Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats

1
1. scibot 07 May 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.jprot.2020.103691
  
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sciencedirect.com/science/article/pii/S1874391920300592
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Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

1
1. scibot 04 May 2021
  
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  AB_10693922
  
  DOI: 10.1016/j.devcel.2020.04.015
  
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sciencedirect.com/science/article/pii/S1534580720303178
Mar 2021
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Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

1
1. scibot 22 Mar 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.molcel.2021.01.009
  
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sciencedirect.com/science/article/pii/S1097276521000095
Feb 2021
www.cell.com www.cell.com

Structure of an inactive conformation of GTP-bound RhoA GTPase

1
1. scibot 26 Feb 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.str.2020.12.015
  
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cell.com/structure/abstract/S0969-2126(20)30482-2
onlinelibrary.wiley.com onlinelibrary.wiley.com

Profilin 1 knockdown prevents ischemic brain damage by promoting M2 microglial polarization associated with the RhoA/ROCK pathway

1
1. scibot 25 Feb 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1002/jnr.24607
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.24607
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ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy

1
1. scibot 11 Feb 2021
  
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  RhoA
  
  DOI: 10.1016/j.celrep.2021.108731
  
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sciencedirect.com/science/article/pii/S2211124721000449
Jan 2021
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ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through Autophagy

1
1. scibot 07 Jan 2021
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.celrep.2020.108594
  
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sciencedirect.com/science/article/pii/S2211124720315837
Sep 2020
www.nature.com www.nature.com

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

1
1. scibot 25 Sep 2020
  
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  RRID:AB_10693922
  
  DOI: 10.1038/s41467-020-17196-3
  
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nature.com/articles/s41467-020-17196-3
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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

1
1. scibot 17 Sep 2020
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.cmet.2020.03.010
  
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sciencedirect.com/science/article/pii/S155041312030125X
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Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

1
1. scibot 14 Sep 2020
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.celrep.2020.107796
  
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sciencedirect.com/science/article/pii/S2211124720307774
Jan 2020
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GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.yexcr.2019.111806
  
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sciencedirect.com/science/article/pii/S0014482719306949
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RhoA Controls Axon Extension Independent of Specification in the Developing Brain

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.cub.2019.09.040
  
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sciencedirect.com/science/article/pii/S096098221931231X
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.ccell.2019.01.009
  
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sciencedirect.com/science/article/pii/S1535610819300431
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Untitled document

1
1. scibot 12 Jan 2020
  
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  RRID:AB_10693922
  
  DOI: 10.1016/j.devcel.2019.04.007
  
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sciencedirect.com/science/article/pii/S1534580719302771
Nov 2018
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Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction

1
1. scibot 05 Nov 2018
  
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  RRID:AB_10693922
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1097276518306981
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1
1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S0092867418309541
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RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis

1
1. scibot 05 Nov 2018
  
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  RRID:AB_10693922
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1535610818300011
Nov 2017
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Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction

1
1. scibot 08 Nov 2017
  
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  RRID:AB_10693922
  
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sciencedirect.com/science/article/pii/S1534580717306743
academic.oup.com academic.oup.com

Deletion of RhoA in Progesterone Receptor–Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice

1
1. scibot 08 Nov 2017
  
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  AB_10693922
  
  Curator: @chewbeccax
  
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academic.oup.com/endo/article/158/7/2168/3814632/Deletion-of-RhoA-in-Progesterone-Receptor