171 Matching Annotations
  1. Jun 2024
  2. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    sciencedirect.com/science/article/pii/S1550413124001918
  3. May 2024
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    Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry
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    sciencedirect.com/science/article/pii/S2666166724002478
  5. 52.53.155.43 52.53.155.43
    Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine
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    52.53.155.43/930a5a5a8b2489c0ec72d025108e06cc5c87d2d2/deans-fielder-et-al-2024-mechanisms-driving-fasting-induced-protection-from-genotoxic-injury-in-the-small-intestine-html.html
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    Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC
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    sciencedirect.com/science/article/pii/S0925443924002382
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    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
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  8. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
    2
    1. scibot 09 May 2024
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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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    1. scibot 08 May 2024
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  10. Apr 2024
  11. www.cell.com www.cell.com
    The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00112-4
  12. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
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  13. Mar 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    1. scibot 27 Mar 2024
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    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss
    1
    1. scibot 17 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10942640/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
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    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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    1. scibot 06 Mar 2024
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  19. Feb 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  21. Jan 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
    1
    1. scibot 23 Jan 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
  23. Dec 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
    1
    1. scibot 02 Dec 2023
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    sciencedirect.com/science/article/pii/S0092867423010814
  25. Nov 2023
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    Tsc2 coordinates neuroprogenitor differentiation
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.isci.2023.108442

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    sciencedirect.com/science/article/pii/S2589004223025191
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    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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    sciencedirect.com/science/article/pii/S1097276521001787
  28. Oct 2023
  29. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    1. scibot 20 Oct 2023
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10529098/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
    1
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      DOI: 10.7554/eLife.85898

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    ncbi.nlm.nih.gov/pmc/articles/PMC10541180/
  32. Sep 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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    sciencedirect.com/science/article/pii/S0022316623352799
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway
    1
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      DOI: 10.7554/eLife.85036

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    ncbi.nlm.nih.gov/pmc/articles/PMC10476966/
  35. Aug 2023
  36. www.biorxiv.org www.biorxiv.org
    Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
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      DOI: 10.1101/2023.08.18.553856

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    biorxiv.org/content/10.1101/2023.08.18.553856v2
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    Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation
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    sciencedirect.com/science/article/pii/S2211124723010434
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    FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
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      DOI: 10.1016/j.molcel.2023.07.017

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    sciencedirect.com/science/article/abs/pii/S1097276523005609
  39. Jul 2023
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC10360084/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328280/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
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      DOI: 10.1158/0008-5472.CAN-22-0945

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    ncbi.nlm.nih.gov/pmc/articles/PMC9812901/
  43. link.springer.com link.springer.com
    mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
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      DOI: 10.1186/s13041-023-01042-w

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    link.springer.com/article/10.1186/s13041-023-01042-w
  44. Jun 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
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      DOI: 10.1016/j.neuron.2023.05.033

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    sciencedirect.com/science/article/pii/S0896627323004348
  46. www.nature.com www.nature.com
    Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
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      DOI: 10.1038/s41467-023-39326-3

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    nature.com/articles/s41467-023-39326-3
  47. aacrjournals.org aacrjournals.org
    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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      DOI: 10.1158/0008-5472.CAN-22-1826

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    aacrjournals.org/cancerres/article/83/7/1128/718992/ROS-Induction-Targets-Persister-Cancer-Cells-with
  48. May 2023
  49. link.springer.com link.springer.com
    Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
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    C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
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    Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study
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  119. Jul 2021
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    F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis – lesson from the adjudin model
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  125. Jun 2021
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  127. May 2021
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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  151. Jan 2021
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    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
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    Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination
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    onlinelibrary.wiley.com/doi/full/10.1111/tra.12552
  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
    1
    1. scibot 05 Nov 2018
      rabbit anti-p-S6 (S240/244) (1:2000, Cell Signaling #5364)

      Curator: @evieth

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      RRID:AB_10694233 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC5824782/
  200. www.sciencedirect.com www.sciencedirect.com
    Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
    1
    1. scibot 05 Nov 2018
      RRID:AB_10694233

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      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

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      RRID:AB_10694233
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    sciencedirect.com/science/article/pii/S1550413117306290
  201. www.sciencedirect.com www.sciencedirect.com
    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
    1
    1. scibot 05 Nov 2018
      RRID:AB_10694233

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      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

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      RRID:AB_10694233
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    sciencedirect.com/science/article/pii/S0092867417312631
  202. www.sciencedirect.com www.sciencedirect.com
    Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation
    1
    1. scibot 05 Nov 2018
      RRID:AB_10694233

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      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

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      RRID:AB_10694233
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    sciencedirect.com/science/article/pii/S0092867417311236
  203. Nov 2017
  204. www.sciencedirect.com www.sciencedirect.com
    mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein
    1
    1. scibot 08 Nov 2017
      RRID:AB_10694233

      Curator: @Jmenke

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      RRID:AB_10694233 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517306081
  205. www.jneurosci.org www.jneurosci.org
    PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network
    1
    1. scibot 08 Nov 2017
      RRID:AB_10694233

      Curator: @patriciaelyse_

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      RRID:AB_10694233 RRIDCUR:Validated
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    jneurosci.org/content/37/36/8595
  206. www.sciencedirect.com www.sciencedirect.com
    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
    1
    1. scibot 08 Nov 2017
      RRID:AB_10694233

      Curator: @Jmenke

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      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

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      RRID:AB_10694233 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1550413117304904
  207. www.sciencedirect.com www.sciencedirect.com
    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
    1
    1. scibot 08 Nov 2017
      RRID:AB_10694233

      Curator: @Jmenke

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      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

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      RRID:AB_10694233 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1534580717305968
  208. elifesciences.org elifesciences.org
    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
    1
    1. scibot 08 Nov 2017
      AB_10694233

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

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      RRID:AB_10694233 RRIDCUR:Validated
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    elifesciences.org/articles/25237
  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
    2
    1. scibot 08 Nov 2017
      AB_10694233

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

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      RRID:AB_10694233 RRIDCUR:Validated
    2. scibot 08 Nov 2017
      AB_10694233

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

      SciCrunch record: RRID:AB_10694233

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      RRID:AB_10694233 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC5241115/