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    The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
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  3. Apr 2024
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    12958_2024_1204_MOESM1_ESM-html.html
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  5. Mar 2024
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    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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    Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss
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    ncbi.nlm.nih.gov/pmc/articles/PMC10942640/
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    The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
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    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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  11. Feb 2024
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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  13. Jan 2024
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    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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  15. Dec 2023
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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  17. Nov 2023
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    Tsc2 coordinates neuroprogenitor differentiation
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    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
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  20. Oct 2023
  21. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex
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    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
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  24. Sep 2023
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    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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    A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway
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  27. Aug 2023
  28. www.biorxiv.org www.biorxiv.org
    Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
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    Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation
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    FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
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  31. Jul 2023
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    Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury
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    Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice
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    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
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    mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
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  36. Jun 2023
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    Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
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    Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
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    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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  40. May 2023
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    Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
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    C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
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    Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment
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  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
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  46. Apr 2023
  47. europepmc.org europepmc.org
    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice
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    Translational and post-translational dynamics in a model peptidergic system
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  50. www.biorxiv.org www.biorxiv.org
    Maturation of Nucleus Accumbens Synaptic Transmission Signals a Critical Period for the Rescue of Social Deficits in a Mouse Model of Autism Spectrum Disorder
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      DOI: 10.1101/2023.02.08.527742

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    biorxiv.org/content/10.1101/2023.02.08.527742v1
  51. Mar 2023
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    Large neutral amino acid levels tune perinatal neuronal excitability and survival
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    Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
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    Injury primes mutation-bearing astrocytes for dedifferentiation in later life
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    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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  64. Sep 2022
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    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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    F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis – lesson from the adjudin model
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  119. May 2021
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    The non-hormonal male contraceptive adjudin exerts its effects via MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407
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  150. Oct 2020
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    Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors
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    mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model
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    Tau Reduction Prevents Key Features of Autism in Mouse Models
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    A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas
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    mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
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    mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance
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    Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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    mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein
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    PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network
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    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
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    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
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    elifesciences.org/articles/25237
  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
    2
    1. scibot 08 Nov 2017
      AB_10694233

      Curator: @gabimpine

      Resource used:

      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

      SciCrunch record: RRID:AB_10694233

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_10694233 RRIDCUR:Validated
    2. scibot 08 Nov 2017
      AB_10694233

      Curator: @gabimpine

      Resource used:

      (Cell Signaling Technology Cat# 5364, RRID:AB_10694233)

      SciCrunch record: RRID:AB_10694233

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_10694233 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC5241115/