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Nov 2025
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The pan-cancer mutational landscape of MLL3 and its impact on prognosis and immunochemotherapy

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  DOI: 10.1016/j.celrep.2025.116548
  
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sciencedirect.com/science/article/pii/S2211124725013191
Sep 2025
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Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

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  DOI: 10.1016/j.celrep.2025.116185
  
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sciencedirect.com/science/article/pii/S2211124725009568
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Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci

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  DOI: 10.1016/j.xgen.2025.100982
  
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cell.com/cell-genomics/abstract/S2666-979X(25)00238-1
Jul 2025
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Multi-omics analysis reveals single-cell meiotic hotspot dynamics and epigenomic regulations in female mammals

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sciencedirect.com/science/article/pii/S2211124725008538
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Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis

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  DOI: 10.1016/j.neuron.2025.06.016
  
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sciencedirect.com/science/article/pii/S089662732500474X
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression

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  DOI: 10.1016/j.celrep.2025.115775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12302258/
May 2025
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Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression

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  DOI: 10.1016/j.celrep.2025.115673
  
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sciencedirect.com/science/article/pii/S2211124725004449
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Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of LSD1 and OXPHOS

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1. scibot 16 May 2025
  
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sciencedirect.com/science/article/pii/S2211124725003900
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KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.002
  
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sciencedirect.com/science/article/pii/S1535610825001394
Jan 2025
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Single-molecule systems for the detection and monitoring of plasma-circulating nucleosomes and oncoproteins in diffuse midline glioma

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  DOI: 10.1016/j.xcrm.2024.101918
  
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sciencedirect.com/science/article/pii/S266637912400689X
Dec 2024
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Porphyromonas gingivalis-Lipopolysaccharide Induced Gingival Fibroblasts Trained Immunity Sustains Inflammation in Periodontitis

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1. scibot 13 Dec 2024
  
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  DOI: 10.1111/jre.13372
  
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onlinelibrary.wiley.com/doi/10.1111/jre.13372
Oct 2024
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Multiplexed chromatin immunoprecipitation sequencing for quantitative study of histone modifications and chromatin factors

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1. scibot 08 Oct 2024
  
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  DOI: 10.1038/s41596-024-01058-z
  
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link.springer.com/article/10.1038/s41596-024-01058-z
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Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance

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1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.stem.2024.09.008
  
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sciencedirect.com/science/article/pii/S1934590924003229
May 2024
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Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114180
  
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sciencedirect.com/science/article/pii/S2211124724005084
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Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

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1. scibot 09 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114211
  
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sciencedirect.com/science/article/pii/S2211124724005394
Apr 2024
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Cis-regulatory control of transcriptional timing and noise in response to estrogen

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1. scibot 25 Apr 2024
  
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  DOI: 10.1016/j.xgen.2024.100542
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11099348/
Mar 2024
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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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1. scibot 29 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.032
  
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sciencedirect.com/science/article/pii/S1097276524001758
Feb 2024
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Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113888
  
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sciencedirect.com/science/article/pii/S221112472400216X
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EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis

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1. scibot 09 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113714
  
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sciencedirect.com/science/article/pii/S2211124724000421
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Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancer

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.xcrm.2024.101396
  
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sciencedirect.com/science/article/pii/S2666379124000053
Oct 2023
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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1. scibot 12 Oct 2023
  
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  DOI: 10.1016/j.molcel.2021.03.009
  
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sciencedirect.com/science/article/pii/S1097276521001775
Jul 2023
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Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.007
  
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sciencedirect.com/science/article/pii/S1097276523004306
Apr 2023
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Genome graphs detect human polymorphisms in active epigenomic state during influenza infection

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1. scibot 08 Apr 2023
  
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  DOI: 10.1016/j.xgen.2023.100294
  
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sciencedirect.com/science/article/pii/S2666979X23000605
Dec 2022
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SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

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1. scibot 01 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111727
  
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sciencedirect.com/science/article/pii/S2211124722016059
Sep 2022
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Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters

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1. scibot 15 Sep 2022
  
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  RRID:AB_10695148
  
  DOI: 10.1016/j.isci.2022.105013
  
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sciencedirect.com/science/article/pii/S2589004222012858
Jun 2022
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Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

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1. scibot 18 Jun 2022
  
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  DOI: 10.1016/j.molcel.2022.05.023
  
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sciencedirect.com/science/article/pii/S1097276522004907
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Dynamic Chromatin States Coupling with Key Transcription Factors in Colitis-Associated Colorectal Cancer

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1. scibot 18 Jun 2022
  
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  AB_10
  
  DOI: 10.1002/advs.202200536
  
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pmc.ncbi.nlm.nih.gov/articles/PMC9376751/
May 2022
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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

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1. scibot 25 May 2022
  
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  DOI: 10.1016/j.cell.2022.04.034
  
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sciencedirect.com/science/article/pii/S0092867422005323
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KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4

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1. scibot 11 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110788
  
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sciencedirect.com/science/article/pii/S2211124722005551
Apr 2022
www.nature.com www.nature.com

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

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1. scibot 12 Apr 2022
  
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  DOI: 10.1038/s41418-022-00983-4
  
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nature.com/articles/s41418-022-00983-4
Mar 2022
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PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation

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1. scibot 31 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110603
  
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sciencedirect.com/science/article/pii/S2211124722003515
Jan 2022
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Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis

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1. scibot 19 Jan 2022
  
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  DOI: 10.1016/j.neuron.2021.12.019
  
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sciencedirect.com/science/article/pii/S0896627321010369
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

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1. scibot 01 Dec 2021
  
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  DOI: 10.7554/eLife.67952
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8626089/
Nov 2021
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CUT&Tag-BS for simultaneous profiling of histone modification and DNA methylation with high efficiency and low cost

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1. scibot 16 Nov 2021
  
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  5326S
  
  DOI: 10.1016/j.crmeth.2021.100118
  
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sciencedirect.com/science/article/pii/S266723752100182X
Sep 2021
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SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling

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1. scibot 28 Sep 2021
  
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  DOI: 10.1016/j.stem.2021.09.004
  
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sciencedirect.com/science/article/pii/S1934590921003805
Jul 2021
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Establishment, maintenance, and recall of inflammatory memory

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.stem.2021.07.001
  
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Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release

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  DOI: 10.1016/j.molcel.2021.03.008
  
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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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  DOI: 10.1016/j.ccell.2020.07.008
  
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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

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  DOI: 10.1016/j.ccell.2020.04.014
  
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MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity

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  DOI: 10.1038/s41419-021-03647-2
  
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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  DOI: 10.1016/j.molcel.2021.03.009
  
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Sep 2020
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The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107548
  
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KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer

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  DOI: 10.1016/j.ccell.2020.03.005
  
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Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

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1. scibot 12 Sep 2020
  
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  DOI: 10.1016/j.molcel.2020.03.010
  
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Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells

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  DOI: 10.1016/j.celrep.2019.08.046
  
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Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS

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  DOI: 10.1016/j.molcel.2019.10.013
  
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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

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  DOI: 10.1016/j.celrep.2019.10.011
  
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Untitled document

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  DOI: 10.7554/eLife.40364
  
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Nov 2018
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Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies

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Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module

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Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential

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Nov 2017
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ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer

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