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Aug 2025
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ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis

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A Naturally Occurring Urinary Collagen Type I Alpha 1-Derived Peptide Inhibits Collagen Type I-Induced Endothelial Cell Migration at Physiological Concentrations

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pmc.ncbi.nlm.nih.gov/articles/PMC12347341/
Jul 2025
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A naturally occurring urinary collagen type I alpha 1-derived peptide inhibits collagen type I-induced endothelial cell migration at physiological concentrations

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  DOI: 10.1101/2025.07.08.663687
  
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biorxiv.org/content/10.1101/2025.07.08.663687v1
Jun 2025
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Piezo1 senses hyphae and initiates host defense against pathogenic fungi

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sciencedirect.com/science/article/pii/S2211124725006102
May 2025
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Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

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Mar 2025
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In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer

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  DOI: 10.1101/2025.03.20.644389
  
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biorxiv.org/content/10.1101/2025.03.20.644389v1
Feb 2025
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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

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pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
Sep 2024
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mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes

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Jul 2024
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Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer

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Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.

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  DOI: 10.1016/j.atherosclerosis.2024.118531
  
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Jun 2024
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Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform

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Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress

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ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
Apr 2024
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Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling

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1. scibot 27 Apr 2024
  
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  DOI: 10.7554/eLife.94265
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11045221/
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S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis

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The Legionella pneumophila effector DenR hijacks the host NRas proto-oncoprotein to downregulate MAPK signaling

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  DOI: 10.1016/j.celrep.2024.114033
  
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The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells

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Mar 2024
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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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1. scibot 27 Mar 2024
  
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  DOI: 10.1080/15384047.2024.2332000
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
Feb 2024
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Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation

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1. scibot 21 Feb 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10870818/
Jan 2024
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Suppression of the KRAS-NRF2 axis shifts arginine into the phosphocreatine energy system in pancreatic cancer cells

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ncbi.nlm.nih.gov/pmc/articles/PMC10746371/
Nov 2023
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Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

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Sep 2023
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Hydrogen peroxide-dependent oxidation of ERK2 within its D-recruitment site alters its substrate selection

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ncbi.nlm.nih.gov/pmc/articles/PMC10514464/
Jul 2023
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Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5

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mcr-22-1031-html.html

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Jun 2023
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Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice

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  DOI: 10.3390/antiox12061303
  
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mdpi.com/2076-3921/12/6/1303
May 2023
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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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  DOI: 10.1002/mc.23284
  
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Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination

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Feb 2023
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Stress Granules determine the Development of Obesity-associated Pancreatic Cancer

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Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity

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Jan 2023
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SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

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ncbi.nlm.nih.gov/pmc/articles/PMC9715480/
Dec 2022
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The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model

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Nov 2022
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Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

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  DOI: 10.1016/j.celrep.2022.111581
  
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Oct 2022
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Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein

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  DOI: 10.1016/j.celrep.2022.111545
  
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sciencedirect.com/science/article/pii/S2211124722014012
Sep 2022
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Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters

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  DOI: 10.1038/s41380-022-01773-7
  
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nature.com/articles/s41380-022-01773-7
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Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior

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  DOI: 10.1016/j.celrep.2022.111309
  
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sciencedirect.com/science/article/pii/S2211124722011330
May 2022
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Rho–Rho-Kinase Regulates Ras-ERK Signaling Through SynGAP1 for Dendritic Spine Morphology

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Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms

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Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancer

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FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

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3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells

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BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer

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CRAF dimerization with ARAF regulates KRAS-driven tumor growth

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KANPHOS: A Database of Kinase-Associated Neural Protein Phosphorylation in the Brain

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YAP1 and PRDM14 converge to promote cell survival and tumorigenesis

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Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning

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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

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Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission

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Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

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Untitled document

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Untitled document

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Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

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Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

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Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM

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HAND1 and BARX1 act as transcriptional and anatomic determinants of malignancy in gastrointestinal stromal tumor

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A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

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An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells

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Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

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β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

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INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models

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Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality

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The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

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Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells

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Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer

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Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

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Phosphorylated Rasal2 facilitates breast cancer progression

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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

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LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion

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Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization

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Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

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Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition

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Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking

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FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

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Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

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Untitled document

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Region-Specific Suppression of Hypothalamic Responses to Insulin To Adapt to Elevated Maternal Insulin Secretion During Pregnancy

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ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase)

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Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

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Tat 101-Mediated Enhancement of Brain Pericyte Migration Involves Platelet-Derived Growth Factor Subunit B Homodimer: Implications for Human Immunodeficiency Virus-Associated Neurocognitive Disorders

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