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Pre-clinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-wildtype Glioblastoma

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  DOI: 10.1158/1078-0432.CCR-25-0244
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12402800/
Aug 2025
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The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.jbc.2025.110561
  
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sciencedirect.com/science/article/pii/S0021925825024123
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

1
1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1421
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12130801/
May 2025
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LCN2-mediated ferroptosis resistance in tissue homeostasis and early-stage tumorigenesis of the fallopian tube epithelium

1
1. scibot 29 May 2025
  
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  AB_10695803
  
  DOI: 10.1016/j.isci.2025.112654
  
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sciencedirect.com/science/article/pii/S2589004225009150
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CDK4/6 activity is required during G2 arrest to prevent stress induced endoreplication

1
1. scibot 20 May 2025
  
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  DOI: 10.1126/science.adi2421
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11305671/
Apr 2025
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1-Induced LX-2 Human Hepatic Stellate Cells

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1. scibot 17 Apr 2025
  
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  DOI: 10.1096/fj.202403146RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202403146RR
Feb 2025
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SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis

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1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.008
  
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sciencedirect.com/science/article/pii/S1097276525000425
Jan 2025
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Mina53 catalyzes arginine demethylation of p53 to promote tumor growth

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1. scibot 28 Jan 2025
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.celrep.2025.115242
  
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sciencedirect.com/science/article/pii/S2211124725000130
52.53.155.43 52.53.155.43

1-s2.0-S2589004225001142-main-html.html

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1. scibot 23 Jan 2025
  
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  RRID:AB_106958
  
  DOI: 10.1016/j.isci.2025.111854
  
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52.53.155.43/4ba4d4aa1791368b1b3c245d42e19adb8410307c/1-s2.0-S2589004225001142-main-html.html
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Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9

1
1. scibot 07 Jan 2025
  
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  AB_10695803
  
  DOI: 10.1016/j.devcel.2024.12.013
  
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sciencedirect.com/science/article/pii/S1534580724007342
Dec 2024
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Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin

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1. scibot 14 Dec 2024
  
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  AB_10695803
  
  DOI: 10.1016/j.ccell.2024.11.013
  
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sciencedirect.com/science/article/pii/S1535610824004483
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Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

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1. scibot 03 Dec 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1126/scisignal.adp1375
  
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science.org/doi/10.1126/scisignal.adp1375
Sep 2024
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

1
1. scibot 10 Sep 2024
  
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  AB_10695803
  
  DOI: 10.1016/j.cell.2024.08.013
  
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sciencedirect.com/science/article/pii/S0092867424009048
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

1
1. scibot 20 Jul 2024
  
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  RRID:AB_10695803
  
  DOI: 10.7554/eLife.91766
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257678/
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Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon CYP3A5-targeted inhibition

1
1. scibot 18 Jul 2024
  
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  AB_10695803
  
  DOI: 10.1016/j.isci.2024.110289
  
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sciencedirect.com/science/article/pii/S2589004224015141
May 2024
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Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

1
1. scibot 23 May 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.xcrm.2024.101578
  
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sciencedirect.com/science/article/pii/S2666379124002702
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CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication

1
1. scibot 03 May 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1126/science.adi2421
  
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science.org/doi/10.1126/science.adi2421
Apr 2024
rupress.org rupress.org

DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

2
1. scibot 25 Apr 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1083/jcb.202303141
  
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2. scibot 25 Apr 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1083/jcb.202303141
  
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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
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Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication

1
1. scibot 20 Apr 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.devcel.2024.03.032
  
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sciencedirect.com/science/article/pii/S1534580724002004
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo

1
1. scibot 10 Apr 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.isci.2024.109502
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11000015/
Mar 2024
www.nature.com www.nature.com

Light-mediated intracellular polymerization

1
1. scibot 26 Mar 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1038/s41596-024-00970-8
  
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nature.com/articles/s41596-024-00970-8
Feb 2024
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Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling

1
1. scibot 29 Feb 2024
  
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  AB_10
  
  DOI: 10.1016/j.ejphar.2024.176421
  
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  RRID:AB_10695803 RRIDCUR:Unresolved
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sciencedirect.com/science/article/pii/S0014299924001092
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Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1

1
1. scibot 27 Feb 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.celrep.2024.113837
  
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sciencedirect.com/science/article/pii/S2211124724001657
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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway

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1. scibot 14 Feb 2024
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.xcrm.2024.101401
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10897550/
Dec 2023
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Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities

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1. scibot 29 Dec 2023
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.ebiom.2023.104940
  
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sciencedirect.com/science/article/pii/S2352396423005066
Aug 2023
52.53.155.43 52.53.155.43

PIIS2589004223016784-html.html

1
1. scibot 18 Aug 2023
  
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  RRID:AB_106958
  
  DOI: 10.1016/j.isci.2023.107601
  
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  Curator: @olekpark
  
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52.53.155.43/278aedd9024902e5f355d970011dfae536b14f4e/PIIS2589004223016784-html.html
52.53.155.43 52.53.155.43

Nuclear transport surveillance of p53 by nuclear pores in glioblastoma

2
1. scibot 12 Aug 2023
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.celrep.2023.112882
  
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2. scibot 10 Aug 2023
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.celrep.2023.112882
  
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52.53.155.43/64ae675a86b73874b1bb5c50aa8d9678e93e36d6/PIIS2211124723008938-html.html
Mar 2023
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Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers

1
1. scibot 18 Mar 2023
  
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  AB_10695803
  
  DOI: 10.1016/j.xcrm.2023.100977
  
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sciencedirect.com/science/article/pii/S2666379123000836
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells

1
1. scibot 10 Mar 2023
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.ccell.2023.02.010
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10466730/
Feb 2023
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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

1
1. scibot 02 Feb 2023
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.celrep.2023.112033
  
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sciencedirect.com/science/article/pii/S221112472300044X
Jan 2023
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A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

1
1. scibot 25 Jan 2023
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.isci.2023.105935
  
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sciencedirect.com/science/article/pii/S2589004223000123
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Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex

1
1. scibot 19 Jan 2023
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.celrep.2022.111972
  
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sciencedirect.com/science/article/pii/S2211124722018769
Nov 2022
link.springer.com link.springer.com

ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response

1
1. scibot 17 Nov 2022
  
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  RRID:AB_10695803
  
  DOI: 10.1186/s13014-022-02139-7
  
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link.springer.com/article/10.1186/s13014-022-02139-7
Oct 2022
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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

1
1. scibot 04 Oct 2022
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.medj.2022.09.002
  
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sciencedirect.com/science/article/pii/S2666634022004032
Jun 2022
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Poroptosis: a form of cell death depending on plasma membrane nanopores formation

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1. scibot 15 Jun 2022
  
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  AB_10695803
  
  DOI: 10.1016/j.isci.2022.104481
  
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sciencedirect.com/science/article/pii/S2589004222007520
Jul 2021
elifesciences.org elifesciences.org

Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

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1. scibot 31 Jul 2021
  
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  RRID:AB_10695803
  
  DOI: 10.7554/eLife.27301
  
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elifesciences.org/articles/27301
Apr 2021
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p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

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1. scibot 24 Apr 2021
  
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  RRID:AB_10695803
  
  DOI: 10.1016/j.cell.2020.12.025
  
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Jan 2021
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A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapy

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1. scibot 28 Jan 2021
  
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  RRID:AB_10695803
  
  DOI: 10.1007/s10637-020-01042-w
  
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Dec 2020
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Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma

1
1. scibot 15 Dec 2020
  
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  p53
  
  DOI: 10.1016/j.tranon.2020.100982
  
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sciencedirect.com/science/article/pii/S1936523320304745
Sep 2020
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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

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1. scibot 13 Sep 2020
  
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  RRID:AB_331211
  
  DOI: 10.1016/j.molcel.2018.11.006
  
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cell.com/molecular-cell/abstract/S1097-2765(18)30948-1
Jan 2020
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Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures

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  RRID:AB_10695803
  
  DOI: 10.1210/en.2019-00410
  
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academic.oup.com/endo/article/160/11/2600/5535649
Nov 2018
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Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy loss

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1. scibot 05 Nov 2018
  
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  RRID:AB_10695803
  
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Untitled document

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sciencedirect.com/science/article/pii/S2211124718310362