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Mar 2026
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Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation

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  DOI: 10.1016/j.celrep.2026.117046
  
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sciencedirect.com/science/article/pii/S2211124726001245
Jan 2026
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USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit

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  DOI: 10.1016/j.apsb.2025.11.015
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12827889/
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Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer

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  DOI: 10.1158/2159-8290.CD-25-0605
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12793832/
Sep 2025
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Cooperativity between Ras pathway mutations in colonic tumorigenesis

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  DOI: 10.1101/2025.09.05.673994
  
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biorxiv.org/content/10.1101/2025.09.05.673994v1
Jul 2025
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SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
Jun 2025
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A first-in-class EGFR-directed KRAS G12V selective inhibitor

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sciencedirect.com/science/article/pii/S1535610825002259
Feb 2025
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KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31

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sciencedirect.com/science/article/pii/S1534580725000358
Sep 2024
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Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

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  DOI: 10.1038/s44319-024-00217-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
Aug 2024
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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1. scibot 21 Aug 2024
  
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  DOI: 10.1126/science.adk0775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
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Activated dormant stem cells recover spermatogenesis in chemoradiotherapy-induced infertility

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cell.com/cell-reports/fulltext/S2211-1247(24)00911-2
Jul 2024
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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1. scibot 18 Jul 2024
  
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  DOI: 10.1126/science.adk0775
  
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science.org/doi/10.1126/science.adk0775
Mar 2024
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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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1. scibot 27 Mar 2024
  
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  DOI: 10.1080/15384047.2024.2332000
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
Feb 2024
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RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

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1. scibot 16 Feb 2024
  
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  DOI: 10.1126/scisignal.adg5289
  
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  DOI: 10.1126/scisignal.adg5289
  
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science.org/doi/10.1126/scisignal.adg5289
Jan 2024
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RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

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  DOI: 10.1126/scisignal.adg5289
  
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science.org/doi/10.1126/scisignal.adg5289
Nov 2023
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Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP

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1. scibot 17 Nov 2023
  
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sciencedirect.com/science/article/pii/S0014299923006714
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Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients

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  DOI: 10.1016/j.lfs.2023.122237
  
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sciencedirect.com/science/article/pii/S002432052300872X
Oct 2023
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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.molcel.2023.09.007
  
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sciencedirect.com/science/article/pii/S1097276523007025
Aug 2023
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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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sciencedirect.com/science/article/pii/S1535610823002453
Jul 2023
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Oncogenic K-Ras suppresses global miRNA function

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  DOI: 10.1016/j.molcel.2023.06.008
  
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sciencedirect.com/science/article/pii/S109727652300429X
Jun 2023
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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

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  DOI: 10.1016/j.celrep.2023.112696
  
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sciencedirect.com/science/article/pii/S2211124723007076
May 2023
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Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma

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  DOI: 10.1016/j.celrep.2023.112570
  
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sciencedirect.com/science/article/pii/S2211124723005818
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Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma

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sciencedirect.com/science/article/pii/S0006295223002034
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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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1. scibot 05 May 2023
  
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  DOI: 10.1002/mc.23284
  
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onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
Feb 2023
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Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models

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  DOI: 10.1038/s41420-023-01359-4
  
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nature.com/articles/s41420-023-01359-4
Jan 2023
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Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling

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Dec 2022
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Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice

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  DOI: 10.3389/fncel.2022.1021592
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9684630/
Nov 2022
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Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate

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sciencedirect.com/science/article/pii/S2405471222004306
May 2022
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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

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sciencedirect.com/science/article/pii/S1097276522004348
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EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

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  DOI: 10.1158/2159-8290.CD-21-1168
  
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aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
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Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

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  DOI: 10.7554/eLife.76495
  
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elifesciences.org/articles/76495
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Translational Strategies for Repotrectinib in Neuroblastoma

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  DOI: 10.1158/1535-7163.MCT-21-0126
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8571000/
Mar 2022
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Regulation of GTPase function by autophosphorylation

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  DOI: 10.1016/j.molcel.2022.02.011
  
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sciencedirect.com/science/article/pii/S1097276522001162
Feb 2022
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Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells

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  DOI: 10.26508/lsa.202101187
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8807877/
Jan 2022
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Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis

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  DOI: 10.1016/j.devcel.2021.12.015
  
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A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies

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  DOI: 10.1016/j.molcel.2021.07.021
  
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Jul 2021
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KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis

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  DOI: 10.1158/1541-7786.MCR-19-0077
  
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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

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  DOI: 10.1016/j.celrep.2021.109291
  
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Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

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  DOI: 10.1016/j.crmeth.2021.100015
  
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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

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  DOI: 10.1016/j.celrep.2021.108928
  
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Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma

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  total-MEK
  
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Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

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  DOI: 10.1016/j.chembiol.2020.06.012
  
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BPS Publications

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  DOI: 10.1111/bph.14981
  
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

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  DOI: 10.1016/j.celrep.2020.107764
  
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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

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  DOI: 10.1016/j.celrep.2019.08.090
  
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Nov 2018
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An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

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IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase

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Nov 2017
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DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells

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