196 Matching Annotations
  1. Oct 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12496224/
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    Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
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    sciencedirect.com/science/article/pii/S1550413125003869
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    Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors
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    sciencedirect.com/science/article/pii/S2451945625002685
  5. Sep 2025
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    Pharmacological and toxicological profiling of JAMC-4/108: targeted induction of apoptosis in human colorectal cancer cells
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    sciencedirect.com/science/article/pii/S0022356525402407
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pre-clinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-wildtype Glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402800/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221223/
  9. Aug 2025
  10. www.sciencedirect.com www.sciencedirect.com
    Design of multi-target peptide modulators for protein chaperone networks
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    sciencedirect.com/science/article/pii/S0969212625002692
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
  13. Jul 2025
  14. 52.53.155.43 52.53.155.43
    watanabe-et-al-als-associated-rna-binding-proteins-promote-unc13a-transcription-through-rest-downregulation-html.html
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  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286604/
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    IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma
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    nature.com/articles/s41419-025-07839-y
  17. Jun 2025
  18. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202503322
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    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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  20. 52.53.155.43 52.53.155.43
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    Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35504
  23. May 2025
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    Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity
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    sciencedirect.com/science/article/pii/S1931312825001830
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12089620/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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  27. Apr 2025
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    Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib
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    sciencedirect.com/science/article/pii/S2589004225005449
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    BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11964295/
  30. Mar 2025
  31. www.sciencedirect.com www.sciencedirect.com
    Screening of patient-derived organoids identifies mitophagy as a cell-intrinsic vulnerability in colorectal cancer during statin treatment
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    sciencedirect.com/science/article/pii/S2666379125001120
  32. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
  33. Feb 2025
  34. 52.53.155.43 52.53.155.43
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    FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
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    sciencedirect.com/science/article/pii/S1535610825000534
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    ASCL1 restrains ERK1/2 to promote survival of a subset of neuroendocrine lung cancers
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    aacrjournals.org/mct/article/23/12/1789/750248/ASCL1-Restrains-ERK1-2-to-Promote-Survival-of-a
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    PPM1G dephosphorylates α-catenin to maintain the integrity of adherens junctions and regulates apoptosis in Sertoli cells
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    SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis
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  40. Jan 2025
  41. www.sciencedirect.com www.sciencedirect.com
    Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
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    SLC7A5 is required for cancer cell growth under arginine-limited conditions
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  43. Dec 2024
  44. www.sciencedirect.com www.sciencedirect.com
    A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules
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    RNA sensing induced by chromosome missegregation augments anti-tumor immunity
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  47. Nov 2024
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532780/
  49. Oct 2024
  50. www.sciencedirect.com www.sciencedirect.com
    Denosumab stimulates spermatogenesis in infertile men with preserved Sertoli cell capacity
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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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  52. Aug 2024
  53. www.biorxiv.org www.biorxiv.org
    Ferroptosis susceptibility of melanoma cells: dependence on cell-type, acquired drug resistance, and medium composition
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    biorxiv.org/content/10.1101/2024.08.12.607529v1
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Potential of GSPT1 as a novel target for glioblastoma therapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11310507/
  55. cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com
    Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma
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    cellandbioscience.biomedcentral.com/article/10.1186/s13578-021-00640-2
  56. Jul 2024
  57. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
  58. www.cell.com www.cell.com
    Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer
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    cell.com/cancer-cell/abstract/S1535-6108(24)00226-5
  59. www.sciencedirect.com www.sciencedirect.com
    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S0304389424016844
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  61. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  62. Jun 2024
  63. www.cell.com www.cell.com
    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
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    cell.com/iscience/abstract/S2589-0042(24)01357-9
  64. link.springer.com link.springer.com
    Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer
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    link.springer.com/article/10.1038/s41388-024-03081-6
  65. www.biorxiv.org www.biorxiv.org
    A Nonsecretory Antimicrobial Peptide Mediates Inflammatory Organ Damage in Drosophila Renal Tubules
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    biorxiv.org/content/10.1101/2024.06.10.598165v1
  66. www.sciencedirect.com www.sciencedirect.com
    Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
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    sciencedirect.com/science/article/pii/S2589004224010502
  67. www.sciencedirect.com www.sciencedirect.com
    Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S0304383524004051
  68. May 2024
  69. www.biorxiv.org www.biorxiv.org
    Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer
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    biorxiv.org/content/10.1101/2024.05.22.595349v1
  70. www.sciencedirect.com www.sciencedirect.com
    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    sciencedirect.com/science/article/pii/S2666379124002702
  71. www.sciencedirect.com www.sciencedirect.com
    Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts
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    sciencedirect.com/science/article/pii/S2666379124002684
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    SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis
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  73. www.cell.com www.cell.com
    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
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    cell.com/iscience/abstract/S2589-0042(24)01022-8
  74. www.biorxiv.org www.biorxiv.org
    Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma
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    biorxiv.org/content/10.1101/2024.01.12.575058v1
  75. Apr 2024
  76. www.sciencedirect.com www.sciencedirect.com
    The MYCN 5′ UTR as a therapeutic target in neuroblastoma
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  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Caffeic acid does not protect human pancreatic β cells against stearic acid-induced ER stress and apoptosis
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    onlinelibrary.wiley.com/doi/full/10.1002/ejlt.202300206
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996809/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NSAID targets SIRT3 to trigger mitochondrial dysfunction and gastric cancer cell death
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    ncbi.nlm.nih.gov/pmc/articles/PMC10972828/
  80. Mar 2024
  81. www.sciencedirect.com www.sciencedirect.com
    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    sciencedirect.com/science/article/pii/S2211124724003267
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    sciencedirect.com/science/article/pii/S1097276524001291
  83. Feb 2024
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10866396/
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527398/
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC10847737/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome
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    ncbi.nlm.nih.gov/pmc/articles/PMC10829266/
  88. Dec 2023
  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
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    onlinelibrary.wiley.com/doi/10.1002/advs.202305620
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    Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis
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    sciencedirect.com/science/article/pii/S2666379123005591
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    The Crucial Role of Single-Stranded DNA Binding in Enhancing Sensitivity to DNA-Damaging Agents for Schlafen 11 and Schlafen 13
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    Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
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    sciencedirect.com/science/article/pii/S2451945623004221
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TXNDC12 inhibits lipid peroxidation and ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10690572/
  94. Nov 2023
  95. www.sciencedirect.com www.sciencedirect.com
    MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10644001/
  97. Oct 2023
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    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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    sciencedirect.com/science/article/pii/S2666379123004214
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    Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development
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    sciencedirect.com/science/article/pii/S2211124723013220
  100. Sep 2023
  101. www.sciencedirect.com www.sciencedirect.com
    Microenvironmental stiffness induces metabolic reprogramming in glioblastoma
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    sciencedirect.com/science/article/pii/S2211124723011877
  102. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16165
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC10481131/
  104. Aug 2023
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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    ncbi.nlm.nih.gov/pmc/articles/PMC10441460/
  106. link.springer.com link.springer.com
    γ-radiation-induced damage on normal hepatocytes and its protection by ethyl cinnamate
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    link.springer.com/article/10.1007/s10967-023-09067-0
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors
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  222. Jan 2020
  223. iovs.arvojournals.org iovs.arvojournals.org
    Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal
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  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  225. www.sciencedirect.com www.sciencedirect.com
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  226. www.mdpi.com www.mdpi.com
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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    BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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  235. Nov 2018
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    NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus
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    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression
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    Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells
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    Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
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  247. Nov 2017
  248. elifesciences.org elifesciences.org
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