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Discovery and Preclinical Validation of a Clinically Optimized Mitochondrial Complex I Modulator for Alzheimer’s Disease

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1. scibot 24 Apr 2026
  
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  DOI: 10.64898/2026.04.10.717554
  
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biorxiv.org/content/10.64898/2026.04.10.717554v1
Nov 2025
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Stra8 links neuronal activity to inhibitory circuit protection in the adult mouse brain

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116513
  
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sciencedirect.com/science/article/pii/S2211124725012847
Sep 2025
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Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease

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1. scibot 16 Sep 2025
  
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  DOI: 10.1016/j.ebiom.2025.105924
  
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sciencedirect.com/science/article/pii/S2352396425003688
May 2025
www.cell.com www.cell.com

mTor limits autophagy to facilitate cell volume expansion and rapid wound repair in Drosophila embryos

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.devcel.2024.12.039
  
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cell.com/developmental-cell/abstract/S1534-5807(24)00778-0
Mar 2025
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Screening of patient-derived organoids identifies mitophagy as a cell-intrinsic vulnerability in colorectal cancer during statin treatment

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.102039
  
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sciencedirect.com/science/article/pii/S2666379125001120
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Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression

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1. scibot 23 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.023
  
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cell.com/immunity/fulltext/S1074-7613(25)00090-1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer’s disease

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1. scibot 13 Mar 2025
  
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  RRID:AB_10707365
  
  DOI: 10.1101/2025.02.12.637918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870434/
Feb 2025
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ERK inhibits osteoclast differentiation in RAW 264.7 cells through the osteoprotegerin-mediated autophagy

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.bone.2025.117424
  
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sciencedirect.com/science/article/pii/S8756328225000365
Dec 2024
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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

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1. scibot 02 Dec 2024
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2024.114984
  
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sciencedirect.com/science/article/pii/S2211124724013354
Nov 2024
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Opposing roles for AMPK in regulating distinct mitophagy pathways

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1. scibot 20 Nov 2024
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.molcel.2024.10.025
  
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sciencedirect.com/science/article/pii/S1097276524008657
Aug 2024
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Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

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1. scibot 22 Aug 2024
  
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  AB_10707365
  
  DOI: 10.1016/j.celrep.2024.114663
  
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sciencedirect.com/science/article/pii/S2211124724010143
Jul 2024
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Pro-survival signaling regulates lipophagy essential for multiple myeloma resistance to stress-induced death

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1. scibot 18 Jul 2024
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2024.114445
  
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sciencedirect.com/science/article/pii/S2211124724007745
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Increased regional activity of a pro-autophagy pathway in schizophrenia as a contributor to sex differences in the disease pathology

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1. scibot 17 Jul 2024
  
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  AB_10707365
  
  DOI: 10.1016/j.xcrm.2024.101652
  
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sciencedirect.com/science/article/pii/S2666379124003665
May 2024
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TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

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1. scibot 30 May 2024
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2024.114294
  
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sciencedirect.com/science/article/pii/S2211124724006223
academic.oup.com academic.oup.com

Adiponectin inhibits the progression of obesity-associated papillary thyroid carcinoma through autophagy

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1. scibot 22 May 2024
  
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  RRID:AB_10707365
  
  DOI: 10.1210/endocr/bqae030
  
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academic.oup.com/endo/article-abstract/165/5/bqae030/7630457
Nov 2023
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Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice

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1. scibot 29 Nov 2023
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.isci.2023.108269
  
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sciencedirect.com/science/article/pii/S2589004223023465
Sep 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects

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1. scibot 22 Sep 2023
  
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  AB_10707365
  
  DOI: 10.1111/acel.13954
  
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onlinelibrary.wiley.com/doi/10.1111/acel.13954
Aug 2023
52.53.155.43 52.53.155.43

PIIS2589004223017029-html.html

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1. scibot 18 Aug 2023
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.isci.2023.107625
  
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52.53.155.43/258d74bd1c79cf4d725c254c0f9188b69c056c90/PIIS2589004223017029-html.html
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Restored autophagy is protective against PAK3-induced cardiac dysfunction

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1. scibot 17 Jun 2023
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.isci.2023.106970
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10265534/
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Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

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1. scibot 03 Jun 2023
  
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  RRID:AB_10707365
  
  DOI: 10.1158/0008-5472.CAN-22-2525
  
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aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
May 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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1. scibot 05 May 2023
  
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  RRID:AB_10707365
  
  DOI: 10.1002/cac2.12332
  
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onlinelibrary.wiley.com/doi/10.1002/cac2.12332
Feb 2023
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An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation

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1. scibot 02 Feb 2023
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.chembiol.2023.01.003
  
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sciencedirect.com/science/article/pii/S2451945623000260
Dec 2022
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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

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1. scibot 24 Dec 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2022.111862
  
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sciencedirect.com/science/article/pii/S2211124722017582
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Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis

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1. scibot 24 Dec 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2022.111850
  
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sciencedirect.com/science/article/pii/S2211124722017429
Nov 2022
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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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1. scibot 17 Nov 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.molcel.2022.10.026
  
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sciencedirect.com/science/article/pii/S1097276522010541
Oct 2022
www.nature.com www.nature.com

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

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1. scibot 16 Oct 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1038/s41467-022-33749-0
  
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nature.com/articles/s41467-022-33749-0
Sep 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Autophagy modulates cell fate decisions during lineage commitment

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1. scibot 09 Sep 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1080/15548627.2021.2008691
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9450964/
Jul 2022
link.springer.com link.springer.com

Transmissible ER stress between macrophages and tumor cells configures tumor microenvironment

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1. scibot 09 Jul 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1007/s00018-022-04413-z
  
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link.springer.com/article/10.1007/s00018-022-04413-z
Jun 2022
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miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells

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1. scibot 07 Jun 2022
  
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  RRID:AB_10707365
  
  DOI: 10.31083/j.fbl2706175
  
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imrpress.com/journal/FBL/27/6/10.31083/j.fbl2706175
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Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control

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1. scibot 02 Jun 2022
  
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  DOI: 10.1210/endocr/bqac048
  
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academic.oup.com/endo/article/163/6/bqac048/6569208
Feb 2022
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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

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1. scibot 16 Feb 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2022.110365
  
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sciencedirect.com/science/article/pii/S2211124722000869
Jan 2022
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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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1. scibot 26 Jan 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.ccell.2021.12.009
  
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sciencedirect.com/science/article/pii/S1535610821006620
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AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

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1. scibot 05 Jan 2022
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2021.110197
  
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sciencedirect.com/science/article/pii/S2211124721017010
Sep 2021
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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK

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1. scibot 23 Sep 2021
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.molcel.2021.08.025
  
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sciencedirect.com/science/article/pii/S1097276521006924
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 02 Aug 2021
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2018.12.036
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6344045/
Jul 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 27 Jul 2021
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2018.09.065
  
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Jun 2021
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Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

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1. scibot 09 Jun 2021
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.devcel.2021.05.010
  
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A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression

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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2021.109129
  
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Mar 2021
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Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness

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1. scibot 04 Mar 2021
  
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  RRID:AB_10707365
  
  DOI: 10.3390/ijms22041937
  
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Dec 2020
elifesciences.org elifesciences.org

Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

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1. scibot 09 Dec 2020
  
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  RRID:AB_10707365
  
  DOI: 10.7554/eLife.62377
  
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Oct 2020
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Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

1
1. scibot 10 Oct 2020
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.molcel.2020.09.018
  
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Sep 2020
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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

1
1. scibot 17 Sep 2020
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.cell.2020.02.017
  
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HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

1
1. scibot 16 Sep 2020
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2020.107625
  
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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

1
1. scibot 04 Sep 2020
  
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  phosphor‐ULK1
  
  DOI: 10.15252/embr.201949898
  
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AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

1
1. scibot 03 Sep 2020
  
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  pULK1
  
  DOI: 10.1016/j.celrep.2020.108092
  
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Jan 2020
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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

1
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  RRID:AB_10707365
  
  DOI: 10.1016/j.molcel.2019.06.043
  
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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

1
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2019.10.117
  
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.celrep.2018.12.036
  
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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

1
1. scibot 12 Jan 2020
  
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  RRID:AB_10707365
  
  DOI: 10.1016/j.cmet.2018.10.005
  
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Nov 2018
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Untitled document

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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

1
1. scibot 05 Nov 2018
  
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  RRID:AB_10707365
  
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Nov 2017
onlinelibrary.wiley.com onlinelibrary.wiley.com

Pimozide reduces toxic forms of tau in TauC3 mice via AMPK‐mediated autophagy

1
1. scibot 08 Nov 2017
  
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  AB_10707365
  
  Curator: @chewbeccax
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14109/full
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Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection

1
1. scibot 08 Nov 2017
  
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  AB_10707365
  
  Curator: @kaitlinsung
  
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sciencedirect.com/science/article/pii/S1931312817301543