20 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    A triple-action PROTAC for wild-type p53 cancer therapy
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    sciencedirect.com:5037/science/article/pii/S2666379125005403
  3. Aug 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11292958/
  5. Feb 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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    sciencedirect.com/science/article/pii/S1097276524000893
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML
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    ncbi.nlm.nih.gov/pmc/articles/PMC10524644/
  8. Jan 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10105475/
  10. Aug 2023
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9898120/
  12. Apr 2023
  13. www.science.org www.science.org
    Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
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    science.org/doi/10.1126/sciadv.ade3422
  14. Feb 2023
  15. 52.53.155.43 52.53.155.43
    91-html.html
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    52.53.155.43/67ba005538cc0cc62d34c50598f914c3efc88864/91-html.html
  16. Jan 2023
  17. aacrjournals.org aacrjournals.org
    Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells
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    aacrjournals.org/mcr/article/20/12/1785/710999/Loss-of-VOPP1-Contributes-to-BET-Inhibitor
  18. Sep 2022
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC9474293/
  20. Jul 2021
  21. mcr.aacrjournals.org mcr.aacrjournals.org
    Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins
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    mcr.aacrjournals.org/content/17/11/2208
  22. May 2021
  23. www.sciencedirect.com www.sciencedirect.com
    Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
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    sciencedirect.com/science/article/pii/S1097276521003208
  24. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
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    sciencedirect.com/science/article/pii/S1097276520302690
  25. Mar 2021
  26. www.sciencedirect.com www.sciencedirect.com
    TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains
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    sciencedirect.com/science/article/pii/S1097276521000435
  27. Feb 2021
  28. academic.oup.com academic.oup.com
    BET inhibition by JQ1 produces divergent transcriptional regulation of SOCS genes in adipocytes
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    academic.oup.com/endo/article/161/2/bqz034/5686880
  29. Sep 2020
  30. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
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    pubmed.ncbi.nlm.nih.gov/32966794/
  31. Jan 2020
  32. www.sciencedirect.com www.sciencedirect.com
    A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor
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    sciencedirect.com/science/article/pii/S1535610819302934
  33. Nov 2018
  34. www.sciencedirect.com www.sciencedirect.com
    Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy
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    sciencedirect.com/science/article/pii/S009286741831239X
  35. www.sciencedirect.com www.sciencedirect.com
    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
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    sciencedirect.com/science/article/pii/S1535610818300199