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Mar 2026
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Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117106
  
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sciencedirect.com/science/article/pii/S2211124726001841
Feb 2026
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MEDAG functions as an A-kinase-anchoring protein in adipocytes

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.02.001
  
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Dual roles of USP39 in stabilizing PB2 and orchestrating ribonucleoprotein assembly drive H5 influenza virus replication and pathogenicity

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1. scibot 19 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.117002
  
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sciencedirect.com/science/article/pii/S221112472600080X
Nov 2025
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Polyubiquitin architecture editing on collided ribosomes maintains persistent RQC activity

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1. scibot 07 Nov 2025
  
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  DOI: 10.1038/s44318-025-00568-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12583759/
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Nov 2025
  
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  DOI: 10.1152/ajpcell.00602.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12551769/
Oct 2025
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The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells

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1. scibot 30 Oct 2025
  
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  DOI: 10.1016/j.molcel.2025.10.005
  
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sciencedirect.com/science/article/pii/S1097276525008226
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A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116408
  
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USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

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1. scibot 02 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116372
  
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sciencedirect.com/science/article/pii/S221112472501143X
Aug 2025
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Aug 2025
  
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  DOI: 10.1101/2025.07.23.666188
  
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biorxiv.org/content/10.1101/2025.07.23.666188v1
May 2025
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Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia

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1. scibot 22 May 2025
  
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  DOI: 10.1038/s41598-025-01657-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12089620/
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Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1

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1. scibot 16 May 2025
  
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  RRID:AB_3695730
  
  DOI: 10.1016/j.celrep.2025.115688
  
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sciencedirect.com/science/article/pii/S2211124725004590
Apr 2025
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KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway

1
1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115595
  
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sciencedirect.com/science/article/pii/S2211124725003663
Feb 2025
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E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages

1
1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115276
  
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sciencedirect.com/science/article/pii/S2211124725000476
Jan 2025
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Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit

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1. scibot 16 Jan 2025
  
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  DOI: 10.1038/s41467-024-55400-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11706986/
Nov 2024
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Regulatory mechanisms of strigolactone perception in rice

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1. scibot 16 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.009
  
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sciencedirect.com/science/article/pii/S0092867424011577
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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.celrep.2024.114917
  
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sciencedirect.com/science/article/pii/S2211124724012683
Sep 2024
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E3 ubiquitin ligase ANKIB1 attenuates antiviral immune responses by promoting K48-linked polyubiquitination of MAVS

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1. scibot 04 Sep 2024
  
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  AB_10859893
  
  DOI: 10.1016/j.celrep.2024.114687
  
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sciencedirect.com/science/article/pii/S2211124724010386
Aug 2024
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The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response

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1. scibot 20 Aug 2024
  
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  AB_10859893
  
  DOI: 10.1016/j.celrep.2024.114608
  
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sciencedirect.com/science/article/pii/S2211124724009586
Jul 2024
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MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells

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1. scibot 31 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114565
  
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sciencedirect.com/science/article/pii/S2211124724008945
Jun 2024
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The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114366
  
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The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.110196
  
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sciencedirect.com/science/article/pii/S2589004224014214
May 2024
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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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1. scibot 09 May 2024
  
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  DOI: 10.1126/sciadv.adl6082
  
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science.org/doi/10.1126/sciadv.adl6082
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Ubiquitin-mediated regulation of APE2 protein abundance

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1. scibot 07 May 2024
  
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  Cell Signaling Technology #8081
  
  DOI: 10.1016/j.jbc.2024.107337
  
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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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1. scibot 05 May 2024
  
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  DOI: 10.1126/sciadv.adl6082
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11068011/
Apr 2024
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O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114163
  
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ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114156
  
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sciencedirect.com/science/article/pii/S2211124724004844
Mar 2024
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The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

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1. scibot 19 Mar 2024
  
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  DOI: 10.7554/eLife.87386
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10942603/
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Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

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1. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.cmet.2024.02.011
  
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  RRID:AB_10859893
  
  DOI: 10.1016/j.cmet.2024.02.011
  
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sciencedirect.com/science/article/pii/S1550413124000573
Feb 2024
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The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs

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1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.01.012
  
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sciencedirect.com/science/article/pii/S1097276524000480
Dec 2023
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NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62

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1. scibot 22 Dec 2023
  
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  DOI: 10.1038/s41467-023-44033-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
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De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function

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1. scibot 21 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113518
  
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sciencedirect.com/science/article/pii/S2211124723015309
Nov 2023
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RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.molcel.2023.10.012
  
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FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113362
  
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sciencedirect.com/science/article/pii/S2211124723013748
Oct 2023
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MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

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1. scibot 31 Oct 2023
  
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  DOI: 10.1186/s13041-023-01064-4
  
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link.springer.com/article/10.1186/s13041-023-01064-4
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PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly

1
1. scibot 28 Oct 2023
  
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  RRID:AB_10859893
  
  DOI: 10.1016/j.molcel.2023.09.028
  
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TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation

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Molecular mechanism for activation of the 26S proteasome by ZFAND5

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NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62

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UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders

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Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1

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TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away

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RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex

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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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Excessive proteostasis contributes to pathology in fragile X syndrome

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LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus

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Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy

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Delicate regulation of IL-1β-mediated inflammation by cyclophilin A

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Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

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K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

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A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells

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Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

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Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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Feedback repression of PPARα signaling by Let-7 microRNA

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Untitled document

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O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

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Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

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Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation

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Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation

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A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation

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Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

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Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast

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Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

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Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer

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Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

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Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

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Untitled document

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Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State

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sciencedirect.com/science/article/pii/S1097276518308931

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