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Mechanisms of transcription control by distal enhancers from single-gene nanoscopy

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1. scibot 15 Oct 2026
  
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  DOI: 10.1016/j.cell.2026.09.028
  
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sciencedirect.com/science/article/pii/S009286742601130X
Sep 2026
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The crosstalk between alternative splicing and histone ubiquitination modulates fast chemical reprogramming to pluripotency

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1. scibot 27 Sep 2026
  
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  DOI: 10.1016/j.stemcr.2026.103089
  
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sciencedirect.com/science/article/pii/S2213671126003000
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5-Azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia

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1. scibot 16 Sep 2026
  
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  DOI: 10.1016/j.molcel.2026.08.018
  
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sciencedirect.com/science/article/pii/S1097276526005873
Aug 2026
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The R-loop-SPT6-SETD2 axis safeguards H3K36me3 to prevent broad H3K4me3 invasion in mouse oocytes

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1. scibot 27 Aug 2026
  
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  DOI: 10.1016/j.celrep.2026.117813
  
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Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis

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1. scibot 20 Aug 2026
  
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  DOI: 10.1038/s41418-026-01846-y
  
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nature.com/articles/s41418-026-01846-y
Jul 2026
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Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes

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1. scibot 11 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117517
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13349233/
Jun 2026
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Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer

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1. scibot 25 Jun 2026
  
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  DOI: 10.64898/2026.02.18.706652
  
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biorxiv.org/content/10.64898/2026.02.18.706652v2
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BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

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1. scibot 13 Jun 2026
  
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  DOI: 10.1002/2211-5463.70189
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13238917/
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Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency

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1. scibot 07 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117402
  
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sciencedirect.com/science/article/pii/S2211124726004808
May 2026
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Analysis of a BCOR internal tandem duplication in mouse embryonic stem cell to neuronal precursor differentiation

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1. scibot 29 May 2026
  
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  DOI: 10.1093/genetics/iyaf133
  
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dx.doi.org/10.1093/genetics/iyaf133
Apr 2026
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Mechanisms of gene regulation by SRCAP and H2A.Z

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1. scibot 21 Apr 2026
  
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  DOI: 10.1038/s41467-026-70087-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13087030/
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Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation

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1. scibot 17 Apr 2026
  
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  DOI: 10.1158/1541-7786.MCR-25-1153
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13082235/
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H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes

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1. scibot 17 Apr 2026
  
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  DOI: 10.1016/j.molcel.2026.03.014
  
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cell.com/molecular-cell/abstract/S1097-2765(26)00190-5
Mar 2026
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Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains

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1. scibot 05 Mar 2026
  
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  DOI: 10.1016/j.molcel.2026.02.011
  
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sciencedirect.com/science/article/pii/S1097276526001255
Feb 2026
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Chromobox2 inhibition: a novel activity of alisertib, an aurora A kinase inhibitor

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1. scibot 07 Feb 2026
  
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  DOI: 10.1158/1535-7163.MCT-25-0279
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12866977/
Jan 2026
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1-s2.0-S2589004225028536-main-html.html

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.isci.2025.114592
  
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54.241.53.176/240dc6a05105efbe0d3f771207c7fadaa29f2101/1-s2.0-S2589004225028536-main-html.html
Oct 2025
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EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming

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1. scibot 22 Oct 2025
  
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  DOI: 10.1016/j.stem.2025.09.009
  
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sciencedirect.com/science/article/pii/S1934590925003406
Sep 2025
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Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.xgen.2025.100982
  
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cell.com/cell-genomics/abstract/S2666-979X(25)00238-1
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Preventing CpG hypermethylation in oocytes safeguards mouse development

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.devcel.2025.08.005
  
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sciencedirect.com/science/article/pii/S1534580725005052
Aug 2025
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Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation

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  DOI: 10.1016/j.molcel.2025.07.014
  
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sciencedirect.com/science/article/pii/S109727652500615X
Jul 2025
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Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.neuron.2025.06.016
  
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1-s2.0-S2589004225013203-main-html.html

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113059
  
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52.53.155.43/cf5e79d9430fe2c0516d8255d5ed63fff73c6faf/1-s2.0-S2589004225013203-main-html.html
Jun 2025
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Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.029
  
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sciencedirect.com/science/article/pii/S109727652500468X
May 2025
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A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma

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1. scibot 22 May 2025
  
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sciencedirect.com/science/article/pii/S1097276525004058
Apr 2025
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The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.026
  
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Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma

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1. scibot 18 Apr 2025
  
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  DOI: 10.1016/j.xcrm.2025.102077
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12147845/
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METTL3-mediated m6A modification regulates the polycomb repressive complex 1 (PRC1) components BMI1 and RNF2 in hepatocellular carcinoma cells

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  DOI: 10.1158/1541-7786.MCR-24-0362
  
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aacrjournals.org/mcr/article/23/3/190/752031/METTL3-Mediated-m6A-Modification-Regulates-the
Mar 2025
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Isogenic comparison of Airn and Xist reveals core principles of Polycomb recruitment by lncRNAs

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  DOI: 10.1016/j.molcel.2025.02.014
  
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cell.com/molecular-cell/fulltext/S1097-2765(25)00145-5
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Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee

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  DOI: 10.1016/j.stem.2025.02.002
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00041-4
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PRC1 and PRC2 proximal interactome in mouse embryonic stem cells

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  DOI: 10.1016/j.celrep.2025.115362
  
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sciencedirect.com/science/article/pii/S2211124725001330
Feb 2025
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Canonical and non-canonical PRC1 differentially contribute to regulation of neural stem cell fate

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  DOI: 10.26508/lsa.202403006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11814486/
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mcr-24-0362-html.html

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1. scibot 14 Feb 2025
  
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  DOI: 10.1158/1541-7786.mcr-24-0362
  
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52.53.155.43/207b5fa35418e37cf8e0644578bdc1e4a04283c1/mcr-24-0362-html.html
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Downregulation of BASP1 promotes temozolomide resistance in gliomas via epigenetic activation of the FBXO32/NF-κB/MGMT axis

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1541-7786.MCR-22-1012
  
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aacrjournals.org/mcr/article/21/7/648/727475/Downregulation-of-BASP1-Promotes-Temozolomide
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Protocol for visualizing the chromatin assembly properties of epigenetic protein complexes via an HTM module-mediated artificial tethering system

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  DOI: 10.1016/j.xpro.2025.103597
  
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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition

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Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis

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mcr-24-0362-html.html

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Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay

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Multiplexed chromatin immunoprecipitation sequencing for quantitative study of histone modifications and chromatin factors

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Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells

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Enhanced ApcMin/+ adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells

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Improved detection of DNA replication fork-associated proteins

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DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

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H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction

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CBX7C•PHC2 interaction facilitates PRC1 assembly and modulates its phase separation properties

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PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression

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Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate

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XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells

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Chromosome-specific maturation of the epigenome in the Drosophila male germline

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Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells

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Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate

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Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

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Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn

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Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing

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Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

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Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

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Epigenetic reprogramming of imprinting at meiosis

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Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis

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mcr-22-1012-html.html

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BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: implications for therapeutic stratification.

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A hyper-quiescent chromatin state formed during aging is reversed by regeneration

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PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1

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Recycling of modified H2A-H2B provides short-term memory of chromatin states

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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

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Essential role of MESP1-RING1A complex in cardiac differentiation

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BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes

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A small RNA-guided PRC2 complex eliminates DNA as an extreme form of transposon silencing

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Chromosome silencing in vitro reveals trisomy 21 causes cell-autonomous deficits in angiogenesis and early dysregulation in Notch signaling

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Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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Binary outcomes of enhancer activity underlie stable random monoallelic expression

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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

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Nde1 is required for heterochromatin compaction and stability in neocortical neurons

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Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1

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L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy

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Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis

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BMI-1 regulates DNA end resection and homologous recombination repair

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Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis

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Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos

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Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus

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A renal cell carcinoma tumorgraft platform to advance precision medicine

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Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

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Reprogramming CBX8-PRC1 function with a positive allosteric modulator

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NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain

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UV-induced reduction in Polycomb repression promotes epidermal pigmentation

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Untitled document

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The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

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SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States

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An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing

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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

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VAL genes regulate vegetative phase change via miR156-dependent and independent mechanisms

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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

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H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve.

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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

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Comprehensive Chromosome End Remodeling during Programmed DNA Elimination

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Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation

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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

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  DOI: 10.1016/j.celrep.2020.108286
  
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Chromatin Immunoprecipitation of Low Number of FACS-Purified Epidermal Cells

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Silencing Trisomy 21 with XIST in Neural Stem Cells Promotes Neuronal Differentiation

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Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

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PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation

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Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression

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lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

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PRC1 Catalytic Activity Is Central to Polycomb System Function

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7

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Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos

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Epigenetic silencing of a multifunctional plant stress regulator

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  DOI: 10.7554/eLife.47835
  
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Untitled document

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  DOI: 10.1016/j.stem.2019.04.017
  
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Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase

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The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

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A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities

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A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs

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ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

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Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation

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Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

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PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

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Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways

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RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions

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