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Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2

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1. scibot 11 Jul 2026
  
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  DOI: 10.1021/acs.jmedchem.6c00020
  
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sciencedirect.com/org/science/article/pii/S1520480426007842
Jul 2026
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Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP

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1. scibot 05 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.003
  
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sciencedirect.com/science/article/pii/S1097276526003746
Jun 2026
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IL-4/IL-13 signaling suppresses ABT-263-induced apoptosis in senescent human fibroblasts

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1. scibot 04 Jun 2026
  
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  DOI: 10.1016/j.intimp.2026.116939
  
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sciencedirect.com/science/article/pii/S156757692600785X
May 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Combined Inhibition of HRAS and MEK Induces Tumor Regression and Restores Myogenic Differentiation in HRAS-Mutant Rhabdomyosarcoma

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1. scibot 19 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-2985
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13176821/
Mar 2026
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Host-transposon mutualism supports regeneration in planarians

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.devcel.2026.03.001
  
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sciencedirect.com/science/article/pii/S1534580726000870
Feb 2026
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1-s2.0-S2589004226004827-main-html.html

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1. scibot 24 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.115107
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12972699/
Jan 2026
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A positive feedback loop between FGR and p65 sustains satellite glial cell activation and chronic neuropathic pain

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116899
  
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sciencedirect.com/science/article/pii/S2211124725016717
Nov 2025
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Chromatin remodeler Chd7 regulates reactive astrogliosis after ischemic stroke

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116590
  
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sciencedirect.com/science/article/pii/S2211124725013622
Jul 2025
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MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

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1. scibot 03 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.005
  
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sciencedirect.com/science/article/pii/S1097276525005052
Apr 2025
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Generation of hiPSC lines with fusion tagged thyroid hormone receptor α isoforms to study isoform-specific actions of TRα1 and TRα2

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.scr.2025.103720
  
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sciencedirect.com/science/article/pii/S1873506125000704
Mar 2025
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Translation dysregulation in cancer as a source for targetable antigens

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.03.003
  
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sciencedirect.com/science/article/pii/S1535610825000820
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.014
  
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sciencedirect.com/science/article/pii/S1535610825000662
Feb 2025
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Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice

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1. scibot 11 Feb 2025
  
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  DOI: 10.1016/j.isci.2025.111903
  
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sciencedirect.com/science/article/pii/S2589004225001634
Dec 2024
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
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Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer

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1. scibot 13 Dec 2024
  
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  DOI: 10.1038/s44321-024-00161-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11628624/
Sep 2024
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Beyond mitochondrial transfer, cell fusion rescues metabolic dysfunction and boosts malignancy in adenoid cystic carcinoma

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1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114652
  
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sciencedirect.com/science/article/pii/S2211124724010039
Jul 2024
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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1. scibot 18 Jul 2024
  
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  DOI: 10.1038/s41422-024-00985-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
May 2024
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Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng

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1. scibot 31 May 2024
  
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  DOI: 10.1016/j.immuni.2024.05.006
  
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2. scibot 31 May 2024
  
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  DOI: 10.1016/j.immuni.2024.05.006
  
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sciencedirect.com/science/article/pii/S1074761324002590
Apr 2024
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EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy

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1. scibot 05 Apr 2024
  
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  RRID:AB_10892
  
  DOI: 10.1038/s41598-024-57926-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10994939/
Mar 2024
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Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias

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1. scibot 16 Mar 2024
  
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  DOI: 10.1038/s44319-024-00077-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10933458/
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HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

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1. scibot 01 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113870
  
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  DOI: 10.1016/j.celrep.2024.113870
  
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sciencedirect.com/science/article/pii/S2211124724001980
Feb 2024
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Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias

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1. scibot 15 Feb 2024
  
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  DOI: 10.1038/s44319-024-00077-x
  
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embopress.org/doi/10.1038/s44319-024-00077-x
Nov 2023
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MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

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1. scibot 03 Nov 2023
  
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  DOI: 10.15252/embj.2023114558
  
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embopress.org/doi/full/10.15252/embj.2023114558
Sep 2023
www.nature.com www.nature.com

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

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1. scibot 22 Sep 2023
  
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  DOI: 10.1038/s41422-023-00874-4
  
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nature.com/articles/s41422-023-00874-4
Feb 2023
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Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise

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1. scibot 23 Feb 2023
  
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  DOI: 10.1016/j.cmet.2023.01.011
  
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sciencedirect.com/science/article/pii/S1550413123000116
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis

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1. scibot 15 Jan 2023
  
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  DOI: 10.26508/lsa.202201457
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9834662/
Dec 2022
www.jci.org www.jci.org

Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation

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1. scibot 06 Dec 2022
  
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  RRID:AB_10892860
  
  DOI: 10.1172/JCI158096
  
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jci.org/articles/view/158096
Nov 2022
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Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies

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1. scibot 17 Nov 2022
  
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  DOI: 10.1016/j.cmet.2022.10.012
  
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sciencedirect.com/science/article/pii/S1550413122004909
Jun 2022
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G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment

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1. scibot 29 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.111012
  
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sciencedirect.com/science/article/pii/S2211124722008014
Apr 2022
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Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation

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1. scibot 13 Apr 2022
  
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  DOI: 10.1016/j.molcel.2022.03.026
  
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sciencedirect.com/science/article/pii/S1097276522002647
Feb 2022
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Enhanced immunoprecipitation techniques for the identification of RNA binding protein partners: IGF2BP1 interactions in mammary epithelial cells

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1. scibot 04 Feb 2022
  
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  DOI: 10.1016/j.jbc.2022.101649
  
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sciencedirect.com/science/article/pii/S0021925822000898
May 2021
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Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway

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1. scibot 14 May 2021
  
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  DOI: 10.1016/j.isci.2021.102504
  
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sciencedirect.com/science/article/pii/S2589004221004727
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice

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1. scibot 28 Feb 2021
  
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  DOI: 10.1038/s41467-020-20112-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7810685/
Dec 2020
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Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5

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Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3

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1. scibot 26 Nov 2020
  
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  DOI: 10.7554/eLife.61564
  
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Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity

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Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34

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Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5

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  DOI: 10.1016/j.neuron.2020.01.030
  
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Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells

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1. scibot 10 Sep 2020
  
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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

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The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

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  DOI: 10.1016/j.celrep.2018.11.097
  
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cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
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Selective PP2A Enhancement through Biased Heterotrimer Stabilization

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  DOI: 10.1016/j.cell.2020.03.038
  
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γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

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  DOI: 10.1016/j.molcel.2019.09.007
  
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HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP

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  DOI: 10.1016/j.molcel.2019.05.019
  
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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

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  DOI: 10.1016/j.cmet.2019.05.018
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.11.097
  
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