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    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
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    sciencedirect.com/science/article/pii/S2666634024002484
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    Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
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  4. Jul 2024
  5. www.cell.com www.cell.com
    Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity
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    cell.com/cell-reports-medicine/abstract/S2666-3791(24)00353-7
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    Cyclin dependent kinase 9 inhibition reduced programmed death-ligand 1 expression and improved treatment efficacy in hepatocellular carcinoma
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    cell.com/heliyon/abstract/S2405-8440(24)10320-9
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization
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    ncbi.nlm.nih.gov/pmc/articles/PMC11218019/
  8. Jun 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11145177/
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    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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    sciencedirect.com/science/article/pii/S2666379124002842
  11. May 2024
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    Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite
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    sciencedirect.com/science/article/pii/S1535610824001697
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    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
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    Lipid-encapsulated mRNAs encoding complex fusion proteins potentiate anti-tumor immune responses
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    1. scibot 17 May 2024
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    Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy
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    1. scibot 17 May 2024
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  16. Apr 2024
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    Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy
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    sciencedirect.com/science/article/pii/S2211124724004698
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    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
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      DOI: 10.1038/s41467-024-47069-y

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    nature.com/articles/s41467-024-47069-y
  21. Feb 2024
  22. www.biorxiv.org www.biorxiv.org
    Sympathetic Signals Promote Immunosuppressive Neutrophils in Lung Tumors
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      DOI: 10.1101/2024.02.15.580434

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    Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
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  24. Dec 2023
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    NK cells propagate T cell immunity following in situ tumor vaccination
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  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes
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    Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12
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      DOI: 10.1126/sciimmunol.adf4919

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  28. Nov 2023
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    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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    A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
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    sciencedirect.com/science/article/pii/S1534580723005518
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    PD-L1-mediated immune evasion in triple-negative breast cancer is linked to the loss of ZNF652
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  32. Oct 2023
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    Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine
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    Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease
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  35. www.cell.com www.cell.com
    The Transcription Factor IRF4 Determines the Anti-Tumor Immunity of CD8+ T cells
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      DOI: 10.1016/j.isci.2023.108087

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    cell.com/iscience/abstract/S2589-0042(23)02164-8
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    Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
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  37. Sep 2023
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    Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control
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  39. Aug 2023
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    Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
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    The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
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    sciencedirect.com/science/article/pii/S2211124723009166
  42. Jul 2023
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    sciencedirect.com/science/article/pii/S2211124723007751
  44. Jun 2023
  45. 52.53.155.43 52.53.155.43
    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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      DOI: 10.1016/j.immuni.2023.05.008

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    sciencedirect.com/science/article/pii/S107476132300225X
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    PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
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      DOI: 10.1016/j.neuron.2023.05.022

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    sciencedirect.com/science/article/pii/S0896627323003951
  48. www.tandfonline.com www.tandfonline.com
    Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression
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      DOI: 10.1080/2162402X.2023.2219164

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    tandfonline.com/doi/abs/10.1080/2162402X.2023.2219164
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    Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression
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      DOI: 10.1016/j.celrep.2023.112599

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  50. May 2023
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    Proteomics of immune cells from liver tumors reveals immunotherapy targets
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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  53. Apr 2023
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    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
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  57. Mar 2023
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    Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy
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  59. Feb 2023
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    XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
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  61. Jan 2023
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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    MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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  67. Dec 2022
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    Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
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  69. Nov 2022
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    The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity
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  73. Oct 2022
  74. www.cell.com www.cell.com
    Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment
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    The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
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  76. Sep 2022
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  78. Aug 2022
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  80. Jun 2022
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    Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes
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    Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity
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    The SETDB1–TRIM28 complex suppresses antitumor immunity
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  84. May 2022
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    Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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  87. Apr 2022
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
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  90. Mar 2022
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    CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
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  92. Feb 2022
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    Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model
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  95. Jan 2022
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    Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection
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  98. Dec 2021
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  100. Nov 2021
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    CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection
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    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
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  104. Aug 2021
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    Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy
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    Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids
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  109. Jul 2021
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    Discovery of Small Molecules for the Reversal of T Cell Exhaustion
    1
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      InVivoMAb anti-mouse PD-L1

      DOI: 10.1016/j.celrep.2019.10.119

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  111. elifesciences.org elifesciences.org
    Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
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    Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
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    Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells
    1
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      Anti-mouse PD-L1 (B7-H1) clone 10F.9G2

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    Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection
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  115. May 2021
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    Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
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  117. mct.aacrjournals.org mct.aacrjournals.org
    Recombinant Orthopoxvirus Primes Colon Cancer for Checkpoint Inhibitor and Cross-Primes T Cells for Antitumor and Antiviral Immunity
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      DOI: 10.1158/1535-7163.MCT-20-0405

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  118. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity
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      DOI: 10.1016/j.molcel.2020.10.015

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  120. www.sciencedirect.com www.sciencedirect.com
    Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma
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  121. Apr 2021
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    NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
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    HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins
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    Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
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    CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10
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      DOI: 10.1016/j.cell.2020.09.064

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    Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance
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  127. Feb 2021
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    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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  129. www.cell.com www.cell.com
    Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade
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  130. Dec 2020
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    A Two-Step Process of Effector Programming Governs CD4+ T Cell Fate Determination Induced by Antigenic Activation in the Steady State
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  132. Oct 2020
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    PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction
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  134. Sep 2020
  135. www.sciencedirect.com www.sciencedirect.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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      DOI: 10.1016/j.cell.2020.02.019

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  136. www.sciencedirect.com www.sciencedirect.com
    CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization
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      DOI: 10.1016/j.celrep.2020.107784

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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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      DOI: 10.1016/j.immuni.2020.04.014

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  138. www.cell.com www.cell.com
    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
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      DOI: 10.1016/j.immuni.2017.11.003

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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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    Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
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    Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity
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    Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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      Anti-mouse PDL-1 (10F.9G2)

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  144. Jan 2020
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    Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors
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    PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
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    PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage
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    Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens
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    The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
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    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
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  151. www.cell.com www.cell.com
    Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
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  152. Nov 2018
  153. www-sciencedirect-com.ezproxy.is.ed.ac.uk www-sciencedirect-com.ezproxy.is.ed.ac.uk
    CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity
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    Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages
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    sciencedirect.com/science/article/pii/S0092867418311796
  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      RRID:AB_10949073
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    ncbi.nlm.nih.gov/pmc/articles/PMC6775781/
  156. www.sciencedirect.com www.sciencedirect.com
    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1074761317304235
  157. www.sciencedirect.com www.sciencedirect.com
    Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S153561081830223X
  158. www.sciencedirect.com www.sciencedirect.com
    High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1074761318300323
  159. www.sciencedirect.com www.sciencedirect.com
    Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1535610817304713
  160. www.sciencedirect.com www.sciencedirect.com
    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1074761317304806
  161. Nov 2017
  162. www.sciencedirect.com www.sciencedirect.com
    Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
    1
    1. scibot 08 Nov 2017
      BE0101

      Curator: @Jmenke

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

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      RRID:AB_10949073 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S009286741631594X
  163. www.sciencedirect.com www.sciencedirect.com
    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
    1
    1. scibot 08 Nov 2017
      Anti-mouse PD-L1BioXCellCat# BE0101

      Curator: @Jmenke

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      RRID:AB_10949073 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1535610817302982
  164. www.sciencedirect.com www.sciencedirect.com
    Systemic Immunity Is Required for Effective Cancer Immunotherapy
    1
    1. scibot 08 Nov 2017
      AB_10949073

      Curator: @Zeljana_Babic

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S009286741631738X