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    Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis
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    1. scibot 17 Dec 2024
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      DOI: 10.1016/j.neuron.2024.11.006

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    sciencedirect.com/science/article/pii/S0896627324008067
  3. Dec 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11624195/
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    BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells
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  6. Sep 2024
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    TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases
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    Promoter DNA methylation and transcription factor condensation are linked to transcriptional memory in mammalian cells
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    sciencedirect.com/science/article/pii/S2405471224002370
  9. Aug 2024
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    FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia
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    sciencedirect.com/science/article/pii/S1534580724004830
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    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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  12. Jul 2024
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    Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells
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    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
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    sciencedirect.com/science/article/pii/S153561082400237X
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    IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
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    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
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  17. Jun 2024
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    CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis
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    sciencedirect.com/science/article/pii/S2211124724006739
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    Inhibition of HDAC activity directly reprograms murine embryonic stem cells to trophoblast stem cells
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    sciencedirect.com/science/article/pii/S1534580724003265
  20. May 2024
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    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
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    sciencedirect.com/science/article/pii/S1074761324002590
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    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
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    Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs
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    sciencedirect.com/science/article/pii/S266637912400274X
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    Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
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    sciencedirect.com/science/article/pii/S0092867424004483
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    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
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    sciencedirect.com/science/article/pii/S2211124724005394
  26. Apr 2024
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    The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other’s chromatin binding dynamics and transcription in vivo
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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    SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements
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    Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway
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  31. Mar 2024
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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    sciencedirect.com/science/article/pii/S1550413124000500
  35. Feb 2024
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    Canonical Wnt signaling directs the generation of functional human PSC-derived atrioventricular canal cardiomyocytes in bioprinted cardiac tissues
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    Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a
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    Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation
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    sciencedirect.com/science/article/pii/S2211124724000743
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    H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells
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    sciencedirect.com/science/article/pii/S2211124724000354
  40. Jan 2024
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    Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity
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    sciencedirect.com/science/article/pii/S1550413123004679
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in HIV-1 elite controllers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10765318/
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    Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression
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    sciencedirect.com/science/article/pii/S2211124723015875
  44. Dec 2023
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions
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    ncbi.nlm.nih.gov/pmc/articles/PMC10687339/
  46. www.science.org www.science.org
    KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties
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      DOI: 10.1126/sciadv.adh2708

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    science.org/doi/10.1126/sciadv.adh2708
  47. Oct 2023
  48. 52.53.155.43 52.53.155.43
    PIIS0092867423009650-html.html
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  49. Sep 2023
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    Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate
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  51. Aug 2023
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    The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
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    NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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  55. Jul 2023
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    Ketolysis drives CD8+ T cell effector function through effects on histone acetylation
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    A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
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  59. Jun 2023
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    (A) Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis
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  64. May 2023
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    Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis
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    Novel enhancers conferring compensatory transcriptional regulation of Nkx2-5 in heart development
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    MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
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  70. Feb 2023
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    Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation
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    D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase
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  73. Jan 2023
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    Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1
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    Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors
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    Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8
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  78. Dec 2022
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  83. Nov 2022
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  86. Sep 2022
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  88. Aug 2022
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  90. Jul 2022
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    RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis
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  92. Jun 2022
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    Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors
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  95. May 2022
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    The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
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  101. Mar 2022
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  103. Feb 2022
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    Interferons reshape the 3D conformation and accessibility of macrophage chromatin
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  105. Oct 2021
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    Pharmacological preconditioning by TERT inhibitor BIBR1532 confers neuronal ischemic tolerance through TERT-mediated transcriptional reprogramming
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  107. Aug 2021
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    Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements
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      DOI: 10.1016/j.cell.2019.08.013

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  109. Jul 2021
  110. academic.oup.com academic.oup.com
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      DOI: 10.1210/en.2018-00608

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  111. May 2021
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    Glutamine Metabolism Controls Chondrocyte Identity and Function
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      DOI: 10.1016/j.devcel.2020.05.001

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  113. Apr 2021
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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      DOI: 10.1016/j.ccell.2020.07.008

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  115. www.sciencedirect.com www.sciencedirect.com
    The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells
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      DOI: 10.1016/j.devcel.2021.03.008

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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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      DOI: 10.1016/j.ccell.2020.04.014

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    Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
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      DOI: 10.1016/j.celrep.2021.108994

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  118. Feb 2021
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    Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants
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      DOI: 10.1016/j.stem.2021.01.016

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  120. Jan 2021
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    Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
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      DOI: 10.1016/j.xcrm.2020.100188

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  122. Nov 2020
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    Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling
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      DOI: 10.1016/j.celrep.2020.108333

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  124. Oct 2020
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    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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  126. Sep 2020
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    Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells
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      DOI: 10.1016/j.molcel.2020.03.010

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    sciencedirect.com/science/article/pii/S1097276520301581
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Diverse nucleosome Site-Selectivity among histone deacetylase complexes
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      DOI: 10.7554/eLife.57663

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  129. www.sciencedirect.com www.sciencedirect.com
    Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution
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      RRID:AB_2616015

      DOI: 10.1016/j.molcel.2020.05.025

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    NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma
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      DOI: 10.1016/j.celrep.2020.107782

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    Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment
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      RRID:AB_10949503

      DOI: 10.1016/j.molcel.2020.03.018

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    sciencedirect.com/science/article/pii/S1097276520301866
  132. Jan 2020
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    One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages
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      RRID:AB_10949503

      DOI: 10.1016/j.molcel.2019.06.039

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    sciencedirect.com/science/article/pii/S1097276519304964
  134. www.sciencedirect.com www.sciencedirect.com
    Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949887

      DOI: 10.1016/j.cell.2019.08.013

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  135. www.sciencedirect.com www.sciencedirect.com
    Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949503

      DOI: 10.1016/j.cell.2019.07.048

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    sciencedirect.com/science/article/pii/S0092867419308487
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    A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949503

      DOI: 10.1016/j.celrep.2019.10.011

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    sciencedirect.com/science/article/pii/S2211124719313117
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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949503

      DOI: 10.1016/j.celrep.2019.07.027

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    sciencedirect.com/science/article/pii/S2211124719309246
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    The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages
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      RRID:AB_10949503

      DOI: 10.1016/j.immuni.2018.12.018

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    sciencedirect.com/science/article/pii/S1074761318305661
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    LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis
    1
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      RRID:AB_10949503

      DOI: 10.1016/j.ebiom.2018.12.056

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    sciencedirect.com/science/article/pii/S2352396418306339
  140. Nov 2018
  141. www.sciencedirect.com www.sciencedirect.com
    Mutant NPM1 Maintains the Leukemic State through HOX Expression
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    SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function
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    sciencedirect.com/science/article/pii/S1934590918303850
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    A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer
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    sciencedirect.com/science/article/pii/S0092867418306494