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Sequential platinum and PARP Inhibition enhances PD1 immunotherapy efficacy in murine Brca2 mutated pancreatic cancer

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1. scibot 21 Feb 2026
  
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  DOI: 10.1038/s41598-026-35423-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12916747/
Feb 2026
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Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors

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1. scibot 06 Feb 2026
  
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  DOI: 10.1016/j.xcrm.2025.102545
  
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sciencedirect.com/science/article/pii/S2666379125006184
Jan 2026
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IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.019
  
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Dec 2025
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PET Imaging of System A Amino Acid Transport Detects Early Response to Immune Checkpoint Inhibitor Therapy in a Syngeneic Mouse Model

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1. scibot 06 Dec 2025
  
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  DOI: 10.2967/jnumed.125.270466
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12676664/
Nov 2025
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Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.cell.2025.10.030
  
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sciencedirect.com/science/article/pii/S0092867425012358
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Developing a therapeutic elastase that stimulates anti-tumor immunity by selectively killing cancer cells

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1. scibot 13 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102446
  
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sciencedirect.com/science/article/pii/S2666379125005191
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Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.004
  
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sciencedirect.com/science/article/pii/S1074761325004340
Aug 2025
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T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-0416
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11790381/
Jul 2025
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BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102258
  
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Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.07.004
  
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Jun 2025
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Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade

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1. scibot 04 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102141
  
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sciencedirect.com/science/article/pii/S2666379125002149
Apr 2025
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Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance

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1. scibot 02 Apr 2025
  
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  DOI: 10.1158/1078-0432.CCR-23-3616
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11444901/
Mar 2025
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Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy

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1. scibot 01 Mar 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0434
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11831061/
Feb 2025
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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

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1. scibot 28 Feb 2025
  
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  DOI: 10.1016/j.ccell.2025.02.001
  
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sciencedirect.com/science/article/pii/S1535610825000534
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Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance

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1. scibot 07 Feb 2025
  
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  RRID:AB_10950184
  
  DOI: 10.1101/2024.10.28.620093
  
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52.53.155.43/b97c57717b8e9ffd85392521b55861178592850c/2024.10.28.620093.full-html.html
Jan 2025
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Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.cmet.2024.11.012
  
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sciencedirect.com/science/article/pii/S1550413124004807
Oct 2024
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Targeting of CD40 and PD-L1 pathways inhibit progression of oral premalignant lesions in a carcinogen-induced model of oral squamous cell carcinoma

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1. scibot 02 Oct 2024
  
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  DOI: 10.1158/1940-6207.CAPR-20-0418
  
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aacrjournals.org/cancerpreventionresearch/article/14/3/313/47829/Targeting-of-CD40-and-PD-L1-Pathways-Inhibits
Jul 2024
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Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.ccell.2024.06.014
  
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Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

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1. scibot 25 Jul 2024
  
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  DOI: 10.1126/science.adh4567
  
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science.org/doi/10.1126/science.adh4567
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CDK4/6 inhibition sensitizes intracranial tumors to PD-1 blockade in preclinical models of brain metastasis

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1. scibot 18 Jul 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-0433
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10872577/
Jun 2024
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Therapeutic potential of co-signaling receptor modulation in hepatitis B

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.038
  
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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114289
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
Apr 2024
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The diversity of inhibitory receptor co-expression patterns of exhausted CD8+ T cells in oropharyngeal carcinoma

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1. scibot 28 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109668
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11035373/
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Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1

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1. scibot 24 Apr 2024
  
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  DOI: 10.1126/sciimmunol.adj5097
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11034815/
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QDPR deficiency drives immune suppression in pancreatic cancer

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1. scibot 23 Apr 2024
  
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  DOI: 10.1016/j.cmet.2024.03.015
  
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sciencedirect.com/science/article/pii/S1550413124001190
Mar 2024
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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.ccell.2024.02.013
  
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Feb 2024
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

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1. scibot 28 Feb 2024
  
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  RRID:AB_10950184
  
  DOI: 10.1016/j.molcel.2024.01.024
  
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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.cell.2024.01.008
  
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Jan 2024
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Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

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1. scibot 12 Jan 2024
  
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  DOI: 10.1016/j.ccell.2023.12.013
  
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A novel translational PET imaging approach to quantifying abscopal immune activation following targeted radiotherapy and checkpoint blockade.

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.ijrobp.2023.12.047
  
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sciencedirect.com/science/article/pii/S0360301624000038
Dec 2023
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Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1

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1. scibot 01 Dec 2023
  
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  DOI: 10.1126/sciimmunol.adj5097
  
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science.org/doi/10.1126/sciimmunol.adj5097
Sep 2023
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Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

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1. scibot 01 Sep 2023
  
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  DOI: 10.1016/j.xcrm.2023.101171
  
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sciencedirect.com/science/article/pii/S2666379123003245
Aug 2023
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KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

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1. scibot 25 Aug 2023
  
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  DOI: 10.1016/j.ccell.2023.07.002
  
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sciencedirect.com/science/article/abs/pii/S1535610823002428
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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

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1. scibot 23 Aug 2023
  
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  RRID:AB_10950184
  
  DOI: 10.1016/j.celrep.2023.113014
  
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Membrane-localized neoantigens predict the efficacy of cancer immunotherapy

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May 2023
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18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition

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Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy

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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

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Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects

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Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

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Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS

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Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy

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Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity

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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

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PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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  DOI: 10.1016/j.cell.2021.08.020
  
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Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy

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Untitled document

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  DOI: 10.1016/j.cell.2016.08.069
  
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Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

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1. scibot 31 Jul 2021
  
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  Anti-CTLA-4 9H10
  
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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

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1. scibot 31 Jul 2021
  
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  DOI: 10.1016/j.immuni.2018.11.014
  
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Oncolytic Newcastle disease virus expressing a checkpoint inhibitor as a radioenhancing agent for murine melanoma

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1. scibot 27 Jul 2021
  
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  RRID:AB_10
  
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Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

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  DOI: 10.1016/j.cell.2021.05.027
  
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Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages

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  DOI: 10.1016/j.celrep.2020.107643
  
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CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

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Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

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The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

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Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

1
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Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy

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  DOI: 10.1016/j.cell.2019.10.029
  
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Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

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  RRID:AB_10950184
  
  DOI: 10.1016/j.celrep.2019.04.091
  
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cell.com/cell-reports/fulltext/S2211-1247(19)30571-6
Nov 2017
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Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

1
1. scibot 08 Nov 2017
  
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  BE0131
  
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Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade

1
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Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade

1
1. scibot 08 Nov 2017
  
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  Anti-CTLA-4 (clone 9H10)BioXcellCat# BE0131
  
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Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

1
1. scibot 08 Nov 2017
  
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  AB_10950184
  
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