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Recycling endosomes in mature epithelia restrain tumorigenic signaling

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/0008-5472.CAN-18-4075
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6726494/
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Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.molcel.2025.08.014
  
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sciencedirect.com/science/article/pii/S1097276525006641
Aug 2025
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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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1. scibot 14 Aug 2025
  
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  DOI: 10.1126/sciadv.abf9141
  
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science.org/doi/10.1126/sciadv.abf9141
Jun 2025
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RIPK4 promotes epidermal differentiation through phase separation and activation of LATS1/2

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.devcel.2025.05.017
  
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sciencedirect.com/science/article/pii/S1534580725003284
Mar 2025
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YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells

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1. scibot 13 Mar 2025
  
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The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

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1. scibot 11 Mar 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12035956/
Feb 2025
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EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.020
  
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1-s2.0-S2589004225003657-main-html.html

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1. scibot 27 Feb 2025
  
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52.53.155.43/107ddf007a91a860bc8dff8db32efb5e9e4f7784/1-s2.0-S2589004225003657-main-html.html
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Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-3419
  
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aacrjournals.org/cancerres/article/84/18/2968/747793/Scribble-Deficiency-Promotes-Pancreatic-Ductal
Jan 2025
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1-s2.0-S2589004225001075-main-html.html

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1. scibot 23 Jan 2025
  
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Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.isci.2024.111589
  
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sciencedirect.com/science/article/pii/S2589004224028165
Dec 2024
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Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.devcel.2024.11.008
  
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Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.ccell.2024.11.005
  
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sciencedirect.com/science/article/pii/S1535610824004409
Aug 2024
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Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice

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1. scibot 13 Aug 2024
  
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  DOI: 10.1210/endocr/bqad192
  
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academic.oup.com/endo/article/165/2/bqad192/7484626
Jul 2024
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ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart

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1. scibot 04 Jul 2024
  
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  DOI: 10.1101/2024.06.21.600099
  
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biorxiv.org/content/10.1101/2024.06.21.600099v1
May 2024
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YAP/TAZ Drive Agrin–Matrix Metalloproteinase-12 Mediated Diabetic Skin Wound Healing

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.jid.2024.05.005
  
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sciencedirect.com/science/article/pii/S0022202X24003919
Apr 2024
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EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

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1. scibot 16 Apr 2024
  
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  DOI: 10.1016/j.celrep.2021.108883
  
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sciencedirect.com/science/article/pii/S2211124721001972
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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

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1. scibot 05 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.003
  
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Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice

1
1. scibot 04 Apr 2024
  
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Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout

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1. scibot 03 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109487
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10973142/
Mar 2024
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TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves

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1. scibot 27 Mar 2024
  
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  DOI: 10.7554/eLife.87394
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10959528/
Jan 2024
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RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

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1. scibot 20 Jan 2024
  
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  DOI: 10.1126/scisignal.adg5289
  
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science.org/doi/10.1126/scisignal.adg5289
Sep 2023
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Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107964
  
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Aug 2023
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The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

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1. scibot 05 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107449
  
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sciencedirect.com/science/article/pii/S2589004223015262
Jun 2023
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Olig1/2-expressing intermediate lineage progenitors are predisposed to PTEN/p53-loss-induced gliomagenesis and harbor specific therapeutic vulnerabilities

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1. scibot 03 Jun 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-1577
  
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aacrjournals.org/cancerres/article/83/6/890/718574/Olig1-2-Expressing-Intermediate-Lineage
Apr 2023
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Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload

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  DOI: 10.1016/j.celrep.2023.112399
  
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Lysine long-chain fatty acylation regulates the TEAD transcription factor

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  DOI: 10.1016/j.celrep.2023.112388
  
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Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA

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  DOI: 10.1016/j.celrep.2023.112338
  
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sciencedirect.com/science/article/pii/S2211124723003492
Mar 2023
www.embopress.org www.embopress.org

Two Hippo signaling modules orchestrate liver size and tumorigenesis

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  DOI: 10.15252/embj.2022112126
  
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  DOI: 10.15252/embj.2022112126
  
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embopress.org/doi/10.15252/embj.2022112126
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Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate

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  DOI: 10.1016/j.cell.2023.02.010
  
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sciencedirect.com/science/article/pii/S0092867423001277
Dec 2022
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Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

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1. scibot 13 Dec 2022
  
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  DOI: 10.1126/scisignal.abn2743
  
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science.org/doi/10.1126/scisignal.abn2743
Nov 2022
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Multiphase coalescence mediates Hippo pathway activation

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  DOI: 10.1016/j.cell.2022.09.036
  
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sciencedirect.com/science/article/pii/S0092867422012557
Aug 2022
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Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers

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1. scibot 31 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111296
  
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sciencedirect.com/science/article/pii/S2211124722011160
Jul 2022
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Mislocalization of protein kinase A drives pathology in Cushing’s syndrome

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Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

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WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy

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A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer

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Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist

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Mst1/2 is necessary for satellite cell differentiation to promote muscle regeneration

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Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

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Substratum stiffness regulates Erk signaling dynamics through receptor-level control

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Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas

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Untitled document

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Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

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Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer

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The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

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Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity

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Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis

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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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G protein-coupled receptors can control the Hippo/YAP pathway through Gq signaling

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Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension

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Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

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Localized EMT reprograms glial progenitors to promote spinal cord repair

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Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer

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EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

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Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

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A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

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Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling

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Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

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Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

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Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

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Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

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Recycling endosomes in mature epithelia restrain tumorigenic signaling

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Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation

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A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis

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The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

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CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity

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TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

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  DOI: 10.1016/j.celrep.2019.03.021
  
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  DOI: 10.1016/j.cell.2019.01.019
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.076
  
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OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ

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  DOI: 10.1016/j.molcel.2018.10.030
  
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Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

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Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction

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Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

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Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis

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Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development

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YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme

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The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

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YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis

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1. scibot 08 Nov 2017
  
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LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors

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1. scibot 08 Nov 2017
  
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