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Aug 2025
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PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice

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Jun 2025
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Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection

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Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy

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Apr 2025
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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

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Mar 2025
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DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity

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Feb 2025
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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
Dec 2024
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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Aug 2024
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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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TCF19 Impacts a Network of Inflammatory and DNA Damage Response Genes in the Pancreatic β-Cell

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Jul 2024
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A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1

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Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver

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cell.com/cell-reports/abstract/S2211-1247(24)00728-9
Jun 2024
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The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies

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An integrative epigenome-based strategy for unbiased functional profiling of clinical kinase inhibitors

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  DOI: 10.1038/s44320-024-00040-x
  
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May 2024
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Mitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells

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ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.cell.2024.04.025
  
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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation

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  DOI: 10.1016/j.stem.2024.04.015
  
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Apr 2024
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Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration

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  DOI: 10.1016/j.celrep.2024.114114
  
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Oncostatin M signaling drives cancer-associated skeletal muscle wasting

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  DOI: 10.1016/j.xcrm.2024.101498
  
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Mar 2024
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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon

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Feb 2024
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PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

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Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages

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  DOI: 10.1158/2326-6066.CIR-23-0440
  
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aacrjournals.org/cancerimmunolres/article/12/2/247/733768/Engagement-of-CD99-Activates-Distinct-Programs-in
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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

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Dec 2023
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Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation

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Nov 2023
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Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation

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Oct 2023
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MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling

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High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma

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Immune–epithelial cell cross-talk enhances antiviral responsiveness to SARS-CoV-2 in children

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embopress.org/doi/full/10.15252/embr.202357912
Aug 2023
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Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response

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Tryptophan metabolism promotes immune evasion in human pancreatic β cells

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  DOI: 10.1016/j.ebiom.2023.104740
  
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Jul 2023
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Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

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  DOI: 10.1016/j.xcrm.2023.101120
  
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Jun 2023
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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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  DOI: 10.1016/j.cell.2023.05.039
  
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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

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  DOI: 10.1016/j.chembiol.2023.05.007
  
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May 2023
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cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway

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1. scibot 13 May 2023
  
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  DOI: 10.4049/jimmunol.2200351
  
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journals.aai.org/jimmunol/article/210/8/1098/263495/cGAS-Mediates-Inflammation-by-Polarizing
Mar 2023
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Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids

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  DOI: 10.3389/fimmu.2023.1097383
  
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Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling

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Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

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Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis

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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells

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SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

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Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance

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The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

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Extracellular Nicotinamide Phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4

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Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense

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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

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JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction

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Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses

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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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Jul 2021
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Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

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Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.

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A case of Luscan-Lumish syndrome: Possible involvement of enhanced GH signaling

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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

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microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP

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Evasion of type-I interferon by SARS-CoV-2

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Oct 2020
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Evasion of type-I interferon by SARS-CoV-2

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Anti-inflammatory, antioxidant and renoprotective effects of SOCS1 mimetic peptide in the BTBR ob/ob mouse model of type 2 diabetes

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Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation

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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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Activation of peroxisome proliferator‐activated receptor delta suppresses BACE1 expression by up‐regulating SOCS1 in a JAK2/STAT1‐dependent manner

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Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

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Untitled document

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The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent

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Untitled document

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