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CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivo

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1. scibot 20 Aug 2026
  
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  DOI: 10.1016/j.xcrm.2026.103004
  
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sciencedirect.com/science/article/pii/S2666379126004210
May 2026
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Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer

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1. scibot 08 May 2026
  
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  DOI: 10.1007/s10495-026-02340-z
  
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2. scibot 08 May 2026
  
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  RRID:AB_10950972
  
  DOI: 10.1007/s10495-026-02340-z
  
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link.springer.com/article/10.1007/s10495-026-02340-z
Oct 2025
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Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.ccell.2025.09.003
  
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sciencedirect.com/science/article/pii/S1535610825003952
Jun 2025
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Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition

1
1. scibot 04 Jun 2025
  
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  DOI: 10.1186/s12885-025-14361-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12128487/
Mar 2025
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The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2

1
1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.026
  
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sciencedirect.com/science/article/pii/S1074761325000937
Jan 2025
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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101890
  
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sciencedirect.com/science/article/pii/S266637912400661X
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Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders

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1. scibot 09 Jan 2025
  
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  DOI: 10.1016/j.chembiol.2024.12.006
  
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sciencedirect.com/science/article/pii/S2451945624005166
Dec 2024
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Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state

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1. scibot 24 Dec 2024
  
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  DOI: 10.1038/s41418-024-01439-7
  
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nature.com/articles/s41418-024-01439-7
Oct 2024
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PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer

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1. scibot 04 Oct 2024
  
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  DOI: 10.1158/1535-7163.MCT-23-0564
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
Apr 2024
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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

1
1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.113924
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11025316/
Mar 2024
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SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

2
1. scibot 21 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113924
  
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2. scibot 21 Mar 2024
  
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  RRID:AB_10950972
  
  DOI: 10.1016/j.celrep.2024.113924
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11025316/
Nov 2023
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p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP

1
1. scibot 28 Nov 2023
  
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  RRID:AB_10950972
  
  DOI: 10.1016/j.celrep.2023.113486
  
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sciencedirect.com/science/article/pii/S2211124723014985
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Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability

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1. scibot 18 Nov 2023
  
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  RRID:AB_10950972
  
  DOI: 10.7554/eLife.80327
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10651173/
Oct 2023
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Kinome reprogramming is a targetable vulnerability in ESR1 fusion-driven breast cancer

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1. scibot 06 Oct 2023
  
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  RRID:AB_10950972
  
  DOI: 10.1158/0008-5472.CAN-22-3484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10543968/
Jun 2023
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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

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1. scibot 30 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112696
  
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sciencedirect.com/science/article/pii/S2211124723007076
52.53.155.43 52.53.155.43

can-22-3484-html.html

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1. scibot 01 Jun 2023
  
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  DOI: 10.1158/0008-5472.can-22-3484
  
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52.53.155.43/78582fc87eae4b7ad3ee30a95dff40dcb4611547/can-22-3484-html.html
Apr 2023
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UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer

1
1. scibot 26 Apr 2023
  
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  RRID:AB_10950972
  
  DOI: 10.1016/j.celrep.2023.112423
  
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sciencedirect.com/science/article/pii/S2211124723004345
Aug 2022
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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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1. scibot 23 Aug 2022
  
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  DOI: 10.1016/j.molcel.2022.07.014
  
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sciencedirect.com/science/article/pii/S1097276522007109
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Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance

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1. scibot 10 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111177
  
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sciencedirect.com/science/article/pii/S2211124722009901
Jan 2022
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Triple targeting of breast tumors driven by hormonal receptors and HER2

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1. scibot 11 Jan 2022
  
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  RRID:AB_10950972
  
  DOI: 10.1158/1535-7163.MCT-21-0098
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8742793/
Dec 2021
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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

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1. scibot 01 Dec 2021
  
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  DOI: 10.1016/j.celrep.2021.110060
  
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sciencedirect.com/science/article/pii/S2211124721015461
Aug 2021
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The Cancer SENESCopedia: A delineation of cancer cell senescence

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1. scibot 14 Aug 2021
  
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  RRID:AB_10950972
  
  DOI: 10.1016/j.celrep.2021.109441
  
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sciencedirect.com/science/article/pii/S2211124721008585
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Untitled document

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1. scibot 03 Aug 2021
  
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  RRID:AB_10950972
  
  DOI: 10.1016/j.ccell.2018.11.006
  
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sciencedirect.com/science/article/pii/S1535610818305270
Jul 2021
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Untitled document

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1. scibot 29 Jul 2021
  
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  DOI: 10.1016/j.chembiol.2018.11.006
  
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sciencedirect.com/science/article/pii/S2451945618304136
Sep 2020
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Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1

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1. scibot 09 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.03.068
  
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sciencedirect.com/science/article/pii/S2211124720303946
Jan 2020
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_10950972
  
  DOI: 10.1016/j.chembiol.2019.02.015
  
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sciencedirect.com/science/article/pii/S2451945619300704
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.01.004
  
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sciencedirect.com/science/article/pii/S1097276519300048
Nov 2018
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Untitled document

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S2211124718310866
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Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1535610818302289
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Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1535610818300023
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Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1535610817305093
Nov 2017
onlinelibrary.wiley.com onlinelibrary.wiley.com

The antiviral cytokine interferon‐gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein phosphorylation

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1. scibot 08 Nov 2017
  
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  Curator: @chewbeccax
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.23987/full