170 Matching Annotations
  1. Last 7 days
  2. link.springer.com link.springer.com
    African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
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    1. scibot 17 Dec 2024
      RRID:AB_10954442

      DOI: 10.1038/s41594-024-01423-2

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    link.springer.com/article/10.1038/s41594-024-01423-2
  3. Dec 2024
  4. www.sciencedirect.com www.sciencedirect.com
    PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress
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    1. scibot 14 Dec 2024
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      DOI: 10.1016/j.celrep.2024.115066

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    sciencedirect.com/science/article/pii/S2211124724014177
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    Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus
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    1. scibot 10 Dec 2024
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      DOI: 10.1016/j.immuni.2024.11.003

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    sciencedirect.com/science/article/pii/S1074761324005132
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    ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
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    1. scibot 02 Dec 2024
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      DOI: 10.1016/j.celrep.2024.114988

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    sciencedirect.com/science/article/pii/S2211124724013391
  7. Nov 2024
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    AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
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    1. scibot 28 Nov 2024
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      DOI: 10.1016/j.celrep.2024.115001

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    sciencedirect.com/science/article/pii/S2211124724013524
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    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.cub.2024.10.061

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    sciencedirect.com/science/article/pii/S096098222401457X
  10. Sep 2024
  11. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry
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    1. scibot 27 Sep 2024
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      DOI: 10.1096/fj.202302501RR

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    A Versatile Tool for Live-Cell Imaging and Super-Resolution Nanoscopy Studies of HIV-1 Env Distribution and Mobility
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.chembiol.2017.04.007

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    sciencedirect.com/science/article/pii/S2451945617301071
  13. Aug 2024
  14. www.sciencedirect.com www.sciencedirect.com
    ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes
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    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009768
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    BDNF-dependent nano-organization of Neogenin and the WAVE Regulatory Complex promotes actin remodelling in dendritic spines
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    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S2589004224018467
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size
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    1. scibot 21 Aug 2024
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      DOI: 10.1083/jcb.202305003

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    ncbi.nlm.nih.gov/pmc/articles/PMC10857907/
  17. 52.53.155.43 52.53.155.43
    nemeth-et-al-2024-adiponectin-suppresses-stiffness-dependent-pro-fibrotic-activation-of-lung-fibroblasts-html.html
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    1. scibot 20 Aug 2024
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      DOI: 10.25833/g4qt-3356

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    52.53.155.43/b68deb9c62e0885cf46c9d0e6108ed17561f8fea/nemeth-et-al-2024-adiponectin-suppresses-stiffness-dependent-pro-fibrotic-activation-of-lung-fibroblasts-html.html
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    The FXR1 network acts as a signaling scaffold for actomyosin remodeling
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    1. scibot 19 Aug 2024
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      DOI: 10.1016/j.cell.2024.07.015

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    sciencedirect.com/science/article/pii/S009286742400775X
  19. Jul 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of small molecule inhibitors of G3BP-driven stress granule formation
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    1. scibot 30 Jul 2024
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      DOI: 10.1083/jcb.202308083

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    ncbi.nlm.nih.gov/pmc/articles/PMC10824102/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective targeting of mu opioid receptors to primary cilia
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    1. scibot 20 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114164

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    ncbi.nlm.nih.gov/pmc/articles/PMC11257377/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aging Differentially Affects Axonal Autophagosome Formation and Maturation
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      DOI: 10.1080/15548627.2023.2236485

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    ncbi.nlm.nih.gov/pmc/articles/PMC10621248/
  23. www.cell.com www.cell.com
    CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection
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    cell.com/cell-reports/abstract/S2211-1247(24)00734-4
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    The polySUMOylation axis promotes nucleolar release of Tof2 for mitotic exit
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    1. scibot 16 Jul 2024
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  25. www.cell.com www.cell.com
    Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
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    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.molcel.2024.06.008

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    2. scibot 16 Jul 2024
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      DOI: 10.1016/j.molcel.2024.06.008

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    cell.com/molecular-cell/fulltext/S1097-2765(24)00511-2
  26. Jun 2024
  27. www.sciencedirect.com www.sciencedirect.com
    Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells
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      DOI: 10.1016/j.cell.2024.05.001

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    sciencedirect.com/science/article/pii/S0092867424004914
  28. Apr 2024
  29. www.sciencedirect.com www.sciencedirect.com
    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
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      DOI: 10.1016/j.stem.2024.03.004

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    sciencedirect.com/science/article/pii/S1934590924000857
  30. Mar 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
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      DOI: 10.1083/jcb.202307092

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    ncbi.nlm.nih.gov/pmc/articles/PMC10959120/
  32. www.sciencedirect.com www.sciencedirect.com
    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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      DOI: 10.1016/j.molcel.2024.02.037

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    sciencedirect.com/science/article/pii/S1097276524001801
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of meiotic entry by dual inhibition of a key mitotic transcription factor
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    1. scibot 16 Mar 2024
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      DOI: 10.7554/eLife.90425

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  34. Feb 2024
  35. www.sciencedirect.com www.sciencedirect.com
    C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
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      DOI: 10.1016/j.molcel.2024.01.014

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      DOI: 10.1016/j.molcel.2024.01.014

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    sciencedirect.com/science/article/pii/S1097276524000509
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
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      DOI: 10.1016/j.isci.2024.108907

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    Glia trigger endocytic clearance of axonal proteins to promote rodent myelination
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    sciencedirect.com/science/article/pii/S1534580724000285
  38. Jan 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD
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      DOI: 10.1016/j.cmet.2023.12.013

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    sciencedirect.com/science/article/pii/S1550413123004643
  40. Dec 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry
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      DOI: 10.1101/2023.12.06.570443

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    ncbi.nlm.nih.gov/pmc/articles/PMC10723426/
  42. www.sciencedirect.com www.sciencedirect.com
    Intranasal murine pneumonia virus-vectored SARS-CoV-2 vaccine induces mucosal and serum antibodies in macaques
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    sciencedirect.com/science/article/pii/S2589004223025671
  43. www.sciencedirect.com www.sciencedirect.com
    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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      DOI: 10.1016/j.celrep.2023.113581

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    sciencedirect.com/science/article/pii/S2211124723015930
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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      DOI: 10.7554/eLife.87098

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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  45. Nov 2023
  46. www.biorxiv.org www.biorxiv.org
    Recruitment of FBXO22 for Targeted Degradation of NSD2
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      DOI: 10.1101/2023.11.01.564830

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    biorxiv.org/content/10.1101/2023.11.01.564830v1
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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      DOI: 10.1016/j.isci.2023.108196

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    sciencedirect.com/science/article/pii/S2589004223022733
  48. www.sciencedirect.com www.sciencedirect.com
    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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      DOI: 10.1016/j.isci.2023.108169

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    sciencedirect.com/science/article/pii/S2589004223022460
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    APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release
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      DOI: 10.1016/j.celrep.2023.113252

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    sciencedirect.com/science/article/pii/S2211124723012640
  50. Sep 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis
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    Generation of three induced pluripotent stem cell lines from patients with glycogen storage disease type III
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    Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
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  54. Aug 2023
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    The C9ORF72 repeat expansion alters neurodevelopment
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  56. Jul 2023
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    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
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  58. Jun 2023
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    SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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    The CD73 immune checkpoint promotes tumor cell metabolic fitness
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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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  63. May 2023
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    Towards discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes
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    The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
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    APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size
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    Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
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  68. Apr 2023
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    Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP
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    Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus
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    C9ORF72 suppresses JAK-STAT mediated inflammation
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  72. Mar 2023
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    Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
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    Angiotensin Deficient FVB/N Mice are Normotensive
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  75. Feb 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS
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  78. Jan 2023
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    The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
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  80. Dec 2022
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    Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT
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    Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in macaques
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  83. Nov 2022
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    Phenotypic screening identifies hydroxypyridone anti-fungals as novel medicines for the prevention of hypertrophic scars
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  85. Oct 2022
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  87. Aug 2022
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    Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
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    A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase
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  91. Jun 2022
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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  94. Apr 2022
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    Loss of CDKL5 in glutamatergic neurons disrupts hippocampal microcircuitry and leads to memory impairment in mice
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    Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections
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  97. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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  99. Feb 2022
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    Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing
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    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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  102. Jan 2022
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    Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
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  104. Dec 2021
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    EGFR transactivates RON to drive oncogenic crosstalk
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    Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
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  107. Oct 2021
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    Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer
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    Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability
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    SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
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    Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates
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  112. Sep 2021
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    Oncogene-dependent sloppiness in mRNA translation
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STING nuclear partners contribute to innate immune signaling responses
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  115. Aug 2021
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    Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission
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    Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
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    Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas
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    Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of LIN28B/Let-7 signaling by propranolol contributes to infantile hemangioma involution
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    Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis
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  125. www.ahajournals.org www.ahajournals.org
    Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution | Arteriosclerosis, Thrombosis, and Vascular Biology
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  126. Jul 2021
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    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
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    The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators
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    The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis
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    A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals
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  133. Jun 2021
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    NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
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    Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons
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  136. May 2021
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NADPH Oxidase 5 and Melatonin: Involvement in Ram Sperm Capacitation
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    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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    Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis
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    Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension
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    Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
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    Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease
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  143. Apr 2021
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    K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap
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    Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes
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  146. Mar 2021
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    Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain - Ariel Diaz, Paola Merino, Patrick McCann, Manuel A Yepes, Laura G Quiceno, Enrique Torre, Amelia Tomkins, Xiaodong Zhang, Chadwick M Hales, Frank C Tong, Manuel Yepes, 2021
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      IRDye 680RD donkey anti-rabbit

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    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
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    In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates
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    Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
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    The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  154. Feb 2021
  155. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deficiency of Meis1, a transcriptional regulator, in mice and worms: neurochemical and behavioral characterizations with implications in the restless legs syndrome
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  156. www.sciencedirect.com www.sciencedirect.com
    Cone-shaped HIV-1 capsids are transported through intact nuclear pores
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  157. Jan 2021
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    MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
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    TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei
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  160. Nov 2020
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    An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model
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  162. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
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  163. Oct 2020
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    EB1 Directly Regulates APC-Mediated Actin Nucleation
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  165. Sep 2020
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    SynGAP Splice Variants Display Heterogeneous Spatio‐Temporal Expression And Subcellular Distribution In The Developing Mammalian Brain
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    PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
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    Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
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    High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
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    A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance
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    Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
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    A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance
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    Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini
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    Does Melatonin Exert Its Effect on Ram Sperm Capacitation Through Nitric Oxide Synthase Regulation?
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    No evidence for Ago2 translocation from the host erythrocyte into the <i>Plasmodium</i> parasite
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    Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
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    Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans
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    Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells
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    Oncogenic properties and signaling basis of the PAX8‐GLIS3 fusion gene
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  180. Jan 2020
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    Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
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    Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells
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    Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice
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      DOI: 10.7554/eLife.45303

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    Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Properties of Individual Hippocampal Synapses Influencing NMDA-Receptor Activation by Spontaneous Neurotransmission
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    Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
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    Profilin and formin constitute a pacemaker system for robust actin filament growth
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    Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth
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    Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons
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    Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1
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    The Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine to Pregnant Rats Impairs the Development of Nigro-Striatal Dopaminergic Neurons
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    The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype
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    Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
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    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
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    An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State
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    Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration
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    CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis
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    Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming
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    Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response
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    The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs
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