303 Matching Annotations
  1. Last 7 days
  2. www.cell.com www.cell.com
    Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease
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    1. scibot 21 Dec 2024
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00443-8
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    Intron retention of an adhesion GPCR generates 1TM isoforms required for 7TM-GPCR function
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    sciencedirect.com/science/article/pii/S2211124724014293
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    Analyses of translation factors Dbp1 and Ded1 reveal the cellular response to heat stress to be separable from stress granule formation
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    sciencedirect.com/science/article/pii/S2211124724014104
  5. Dec 2024
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    Design principles to tailor Hsp104 therapeutics
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    sciencedirect.com/science/article/pii/S2211124724013561
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    Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles
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    sciencedirect.com/science/article/pii/S1097276524009201
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
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      DOI: 10.1186/s13041-024-01154-x

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    pmc.ncbi.nlm.nih.gov/articles/PMC11600823/
  9. Nov 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
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    Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane
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    sciencedirect.com/science/article/pii/S0969212624004556
  12. www.biorxiv.org www.biorxiv.org
    Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
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  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
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    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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  15. Sep 2024
  16. www.biorxiv.org www.biorxiv.org
    Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2
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  17. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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      DOI: 10.1113/JP286715

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    Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability
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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer
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      DOI: 10.1210/endocr/bqae114

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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
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  22. Aug 2024
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    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
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    sciencedirect.com/science/article/pii/S2211124724009677
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    SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling
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      DOI: 10.1111/jnc.16186

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16186
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    Dual effect of N-terminal deletion of cardiac myosin essential light chain in mitigating cardiomyopathy
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    sciencedirect.com/science/article/pii/S2589004224018169
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    The lateral habenula integrates age and experience to promote social transitions in developing rats
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    Redox heterogeneity in mouse embryonic stem cells individualizes cell fate decisions
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    sciencedirect.com/science/article/pii/S1534580724004453
  28. academic.oup.com academic.oup.com
    DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo
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      DOI: 10.1093/hmg/ddaa037

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    academic.oup.com/hmg/hmg/advance-article-abstract/doi/10.1093/hmg/ddaa037/5803135
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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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  30. Jul 2024
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    An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II
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    Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
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      DOI: 10.1016/j.crmeth.2024.100818

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  33. Jun 2024
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    Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
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      DOI: 10.1038/s41596-024-01006-x

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    Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization
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      DOI: 10.1016/j.intimp.2024.112374

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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    Truncated protein isoforms generate diversity of protein localization and function in yeast
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      DOI: 10.1016/j.cels.2024.03.005

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  38. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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      DOI: 10.7554/elife.92755

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  39. May 2024
  40. 52.53.155.43 52.53.155.43
    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
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      DOI: 10.1152/ajpcell.00669.2023

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    52.53.155.43/76598b44d554c4165a9f84a25bc34c671709ff41/lee-et-al-2024-everolimus-exerts-anticancer-effects-through-inhibiting-the-interaction-of-matrix-metalloproteinase-7-html.html
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    ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum
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    sciencedirect.com/science/article/pii/S1934590924001413
  42. 52.53.155.43 52.53.155.43
    Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
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      DOI: 10.1101/2024.01.12.575269

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  43. Apr 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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      DOI: 10.1016/j.celrep.2024.114152

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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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      DOI: 10.1016/j.celrep.2024.114149

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    sciencedirect.com/science/article/pii/S2211124724004777
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    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression
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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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  49. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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  52. Mar 2024
  53. www.sciencedirect.com www.sciencedirect.com
    Molecular determinants and signaling effects of PKA RIα phase separation
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    Control of meiotic entry by dual inhibition of a key mitotic transcription factor
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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    IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
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  60. Feb 2024
  61. 52.53.155.43 52.53.155.43
    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
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    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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  64. 52.53.155.43 52.53.155.43
    The β6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection
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  65. 52.53.155.43 52.53.155.43
    Identification of an H-Ras nanocluster disrupting peptide
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  66. 52.53.155.43 52.53.155.43
    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity
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    Precision formulation, a new concept to improve dietary amino acid absorption based on the study of cationic amino acid transporters
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  70. Jan 2024
  71. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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    Live-cell imaging defines a threshold in CDK activity at the G2/M transition
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    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  75. Dec 2023
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    Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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    Single-cell analysis reveals a weak macrophage subpopulation response to Mycobacterium tuberculosis infection
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  81. Nov 2023
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    Solid-to-liquid phase transition in the dissolution of cytosolic misfolded-protein aggregates
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    Manipulating the 3D organization of the largest synthetic yeast chromosome
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    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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    Interplay between stochastic enzyme activity and microtubule stability drives detyrosination enrichment on microtubule subsets
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    Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains
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    Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer
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    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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  89. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  90. Oct 2023
  91. www.sciencedirect.com www.sciencedirect.com
    Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2
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      DOI: 10.1016/j.molcel.2023.09.024

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    Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
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      DOI: 10.3389/fnagi.2023.1265151

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    α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The transcriptional regulator Ume6 is a major driver of early gene expression during gametogenesis
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      DOI: 10.1093/genetics/iyad123

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  98. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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  100. Aug 2023
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis
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    Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects
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    A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
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  105. Jul 2023
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
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  108. Jun 2023
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
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      DOI: 10.3389/fonc.2023.1200897

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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
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      DOI: 10.1080/15548627.2023.2169309

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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
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      DOI: 10.1016/j.cell.2023.05.043

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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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      DOI: 10.1021/acs.jproteome.2c00706

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  114. www.mdpi.com www.mdpi.com
    Inducible Knockout of 14-3-3β Attenuates Proliferation and Spheroid Formation in a Human Glioblastoma Cell Line U87MG
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    Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7
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      DOI: 10.1007/s00018-023-04816-6

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  116. May 2023
  117. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    EWSR1 maintains centromere identity
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    Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions
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      DOI: 10.15252/msb.202211164

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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    Calcineurin associates with centrosomes and regulates cilia length maintenance
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  122. Apr 2023
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    RAGE and its ligand amyloid beta promote retinal ganglion cell loss following ischemia-reperfusion injury
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  124. www.biorxiv.org www.biorxiv.org
    The Transcriptional Regulator Ume6 is a Major Driver of Early Gene Expression during Gametogenesis
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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  128. Mar 2023
  129. www.sciencedirect.com www.sciencedirect.com
    Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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  131. Feb 2023
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    Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of DNA damage response by trimeric G-proteins
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  134. www.sciencedirect.com www.sciencedirect.com
    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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  135. Jan 2023
  136. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity
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    Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    Carbonic anhydrases in development: morphological observations and gene expression profiling in sea urchin embryos exposed to acetazolamide
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    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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  141. Dec 2022
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    Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization
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    A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
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    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    Cocaine sensitizes the CD4+ T cells for HIV infection by co-stimulating NFAT and AP-1
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  147. Nov 2022
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    TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo
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    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment
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  151. Oct 2022
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    BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
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  153. Sep 2022
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    Nanobodies identify an activated state of the TRIB2 pseudokinase
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  155. Aug 2022
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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  157. Jul 2022
  158. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma
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    Genome-wide expression and methylation analyses reveal aberrant cell adhesion signaling in tyrosine kinase inhibitor-resistant CML cells
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  160. Jun 2022
  161. www.sciencedirect.com www.sciencedirect.com
    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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  163. Apr 2022
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    Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
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    Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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    FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer
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  167. Mar 2022
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    Local hyperthermia therapy induces browning of white fat and treats obesity
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    RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
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  173. Feb 2022
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    Poly(ADP-ribose) drives condensation of FUS via a transient interaction
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance
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    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    Maternal hypothyroidism in rats reduces placental lactogen, lowers insulin levels and causes glucose intolerance
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  180. Jan 2022
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    NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
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    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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  184. Dec 2021
  185. jasn.asnjournals.org jasn.asnjournals.org
    Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease
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    Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells
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    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
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    The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling
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    The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages
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    Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
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      goat anti-rabbit IRDye680RD

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    Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
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    Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice
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    Passive Immunity to Vibrio cholerae O1 Afforded by a Human Monoclonal IgA1 Antibody Expressed in Milk
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    A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
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    High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
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    HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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      DOI: 10.1016/j.cell.2021.04.022

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    Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms
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    1. scibot 11 May 2021
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      DOI: 10.1016/j.xcrm.2021.100288

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