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Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116993
  
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sciencedirect.com/science/article/pii/S2211124726000719
Feb 2026
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ESM1 SUMOylation mediates bevacizumab resistance in ovarian cancer through ITGB1-FAK-driven angiogenesis

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1. scibot 06 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116927
  
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sciencedirect.com/science/article/pii/S2211124726000057
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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

1
1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116941
  
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sciencedirect.com/science/article/pii/S2211124726000197
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression

1
1. scibot 30 Jan 2026
  
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  RRID:AB_11042321
  
  DOI: 10.7150/ijbs.123790
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12836506/
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Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML

1
1. scibot 30 Jan 2026
  
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  DOI: 10.1016/j.cmet.2026.01.001
  
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sciencedirect.com/science/article/pii/S155041312600001X
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NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

1
1. scibot 30 Jan 2026
  
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  RRID:AB_11
  
  DOI: 10.1002/advs.202513380
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12850156/
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The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis

1
1. scibot 23 Jan 2026
  
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  DOI: 10.1038/s41467-026-68492-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12820292/
54.241.53.176 54.241.53.176

paper2-html.html

1
1. scibot 22 Jan 2026
  
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  AB_11042321
  
  DOI: 10.1002/advs.202509846
  
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54.241.53.176/7004e19049be5918255dd11820146e335ff22431/paper2-html.html
Dec 2025
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JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation

1
1. scibot 23 Dec 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1038/s41588-025-02415-8
  
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nature.com/articles/s41588-025-02415-8
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Liprin-α1 enhances PHLDB3 oncogenic function in colorectal cancer via activation of mTORC2-AKT1 pathway

1
1. scibot 17 Dec 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2025.116722
  
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sciencedirect.com:5037/science/article/pii/S2211124725014949
54.241.53.176 54.241.53.176

s12974-025-03648-4_reference-html.html

1
1. scibot 16 Dec 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1186/s12974-025-03648-4
  
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54.241.53.176/a44cc0e7569e6d3c1fa351bb4696d083040f2f89/s12974-025-03648-4_reference-html.html
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TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1

1
1. scibot 02 Dec 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.isci.2025.113775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12664470/
Nov 2025
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Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma

1
1. scibot 22 Nov 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2025.116588
  
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sciencedirect.com/science/article/pii/S2211124725013609
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Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer

1
1. scibot 06 Nov 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2025.116530
  
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sciencedirect.com/science/article/pii/S2211124725013014
Oct 2025
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The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

1
1. scibot 28 Oct 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2025.116475
  
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sciencedirect.com/science/article/pii/S221112472501246X
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Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells

1
1. scibot 18 Oct 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2025.116448
  
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sciencedirect.com/science/article/pii/S2211124725012197
54.241.53.176 54.241.53.176

1-s2.0-S258900422502036X-main-html.html

1
1. scibot 16 Oct 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.isci.2025.113775
  
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54.241.53.176/26b831e7f0840bfa9e1b964bdef3380422373d34/1-s2.0-S258900422502036X-main-html.html
Sep 2025
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Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS

1
1. scibot 23 Sep 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.redox.2025.103875
  
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sciencedirect.com/science/article/pii/S221323172500388X
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

1
1. scibot 23 Sep 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2025.116323
  
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sciencedirect.com/science/article/pii/S2211124725010940
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mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport

1
1. scibot 19 Sep 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.molcel.2025.08.021
  
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sciencedirect.com/science/article/pii/S1097276525007063
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Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells

1
1. scibot 09 Sep 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.xcrm.2025.102328
  
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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

1
1. scibot 04 Sep 2025
  
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  RRID:AB_11042321
  
  DOI: 10.7554/eLife.103904
  
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elifesciences.org/articles/103904
Aug 2025
52.53.155.43 52.53.155.43

41467_2025_56346_MOESM1_ESM-html.html

1
1. scibot 15 Aug 2025
  
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  AB_11042321
  
  DOI: 10.1038/s41467-025-56346-3
  
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52.53.155.43/0cdd1395338fbad58a2c837457ae32b83153d0d5/41467_2025_56346_MOESM1_ESM-html.html
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SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia

1
1. scibot 13 Aug 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2025.116147
  
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sciencedirect.com/science/article/pii/S2211124725009180
Jul 2025
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BPS Publications

1
1. scibot 30 Jul 2025
  
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  AB_11042321
  
  DOI: 10.1111/bph.70122
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70122
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RFX2-BNIP3 axis-driven adaptive mitophagy promotes resistance to ACK1-targeted therapy in non-small cell lung cancer

1
1. scibot 29 Jul 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1038/s41388-025-03502-0
  
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nature.com/articles/s41388-025-03502-0
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma

1
1. scibot 29 Jul 2025
  
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  RRID:AB_11
  
  DOI: 10.1002/advs.202417795
  
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  Curator: @sonofthor
  
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  RRID:AB_11042321 RRIDCUR:Unresolved
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202417795
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Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners

1
1. scibot 22 Jul 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.xcrm.2025.102241
  
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sciencedirect.com/science/article/pii/S2666379125003143
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Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7

1
1. scibot 22 Jul 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.jbc.2025.110502
  
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52.53.155.43 52.53.155.43

41467_2025_56346_MOESM1_ESM (1)-html.html

1
1. scibot 19 Jul 2025
  
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  AB_11042321
  
  DOI: 10.1038/s41467-025-56346-3
  
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52.53.155.43/1761484a67730362675820c7685649e27bb2d182/41467_2025_56346_MOESM1_ESM (1)-html.html
52.53.155.43 52.53.155.43

Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html

1
1. scibot 08 Jul 2025
  
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  AB_11042321
  
  DOI: 10.1016/j.isci.2025.113054
  
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52.53.155.43/baf73dc4816d69ae4de3fa32641dfd7bd010d8a5/Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

1
1. scibot 02 Jul 2025
  
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  RRID:AB_11042321
  
  DOI: 10.1126/sciadv.adu8422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12189954/
Jun 2025
52.53.155.43 52.53.155.43

kong-et-al-adipose-tissue-secreted-spz5-promotes-distal-tumor-progression-via-toll-6-mediated-hh-pathway-activation-in-html.html

2
1. scibot 28 Jun 2025
  
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  RRID: AB_11042321
  
  DOI: 10.1038/s44318-025-00489-y
  
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  Curator: @sjvitug
  
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2. scibot 28 Jun 2025
  
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  AB_11042321
  
  DOI: 10.1038/s44318-025-00489-y
  
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52.53.155.43/f797b68cc578c5707d96baf6b2dcdbd6b1b6aadb/kong-et-al-adipose-tissue-secreted-spz5-promotes-distal-tumor-progression-via-toll-6-mediated-hh-pathway-activation-in-html.html
www.science.org www.science.org

Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

1
1. scibot 28 Jun 2025
  
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Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila

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VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2

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Sigma-1R–Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS

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PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity

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ZBP1 senses splicing aberration through Z-RNA to promote cell death

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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer

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The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters

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LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia

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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

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Feb 2025
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STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma

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Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

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Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy

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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

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  DOI: 10.1016/j.celrep.2024.115179
  
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YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies

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Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

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SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells

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Rift Valley fever virus coordinates the assembly of a programmable E3 ligase to promote viral replication

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HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma

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MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating USP18/VDAC2 pathway

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TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation

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Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma

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May 2024
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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

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Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity

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An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins

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Apr 2024
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Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects

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TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction

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Feb 2024
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AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ

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CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway

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Jan 2024
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Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells

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p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP

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OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB

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Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies

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Nov 2023
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JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia

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MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

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Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes

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CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis

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Deciphering the functional landscape of phosphosites with deep neural network

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PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ

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The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy

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QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

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Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer

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MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance

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USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis

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Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

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RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits

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Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication

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STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion

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PPT1 Regulation Of HSP90α Depalmitoylation Participates In The Pathogenesis Of Hyperandrogenism

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Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis

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S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway

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TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation

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Brown adipose tissue involution associated with progressive restriction in progenitor competence

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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

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The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy

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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

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Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine

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Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

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Glycogen accumulation and phase separation drives liver tumor initiation

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RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis

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Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation

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Untitled document

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BPS Publications

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EGY3 mediates chloroplastic ROS homeostasis and promotes retrograde signaling in response to salt stress in Arabidopsis

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sciencedirect.com/science/article/pii/S2211124721007828
Jun 2021
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Bacterial RF3 senses chaperone function in co-translational folding

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1. scibot 09 Jun 2021
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.molcel.2021.05.016
  
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sciencedirect.com/science/article/pii/S1097276521004007
May 2021
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UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model

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1. scibot 15 May 2021
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.neuron.2021.04.023
  
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sciencedirect.com/science/article/pii/S0896627321002890
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Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells

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1. scibot 09 May 2021
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.stem.2020.11.018
  
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sciencedirect.com/science/article/pii/S1934590920305828
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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

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1. scibot 07 May 2021
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.molcel.2020.06.023
  
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sciencedirect.com/science/article/pii/S1097276520304251
Apr 2021
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Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival

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1. scibot 10 Apr 2021
  
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  RRID:AB_11042321
  
  DOI: 10.3389/fimmu.2021.633796
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8027073/
Nov 2020
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PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval

1
1. scibot 05 Nov 2020
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2020.108312
  
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  RRIDCUR:Validated RRID:AB_11042321
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sciencedirect.com/science/article/pii/S2211124720313012
Jan 2020
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Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation

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1. scibot 13 Jan 2020
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2019.11.041
  
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Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism

1
1. scibot 13 Jan 2020
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.chom.2019.10.014
  
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Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination

1
1. scibot 13 Jan 2020
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.neuron.2019.02.018
  
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FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

1
1. scibot 12 Jan 2020
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.devcel.2018.12.021
  
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sciencedirect.com/science/article/pii/S1534580718311171

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