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Clearing perivascular light chain-derived amyloid to counteract aging-associated decline in liver regeneration

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1. scibot 07 Nov 2026
  
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  DOI: 10.1016/j.celrep.2026.118227
  
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The ssDNA-binding protein MEIOB sustains synaptonemal complex integrity by stabilizing recombination intermediates during male meiosis

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1. scibot 06 Nov 2026
  
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  DOI: 10.1016/j.isci.2026.118103
  
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The VCPIP1-UBE3A Deubiquitination-Ubiquitination Cascade Contributes to Castration-Resistant Prostate Cancer Progression

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1. scibot 05 Nov 2026
  
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  DOI: 10.1002/advs.78433
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.78433
Oct 2026
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Obesity-Induced PLPE–PTK6–FASN Feedback Loop Drives Enzalutamide Resistance by Exacerbating Lipid Metabolic Dysregulation in Castration-Resistant Prostate Cancer

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1. scibot 23 Oct 2026
  
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  DOI: 10.34133/research.1461
  
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ICAM-1 functions as a functional receptor for encephalomyocarditis virus and reveals a compensatory interplay with ICAM-4

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1. scibot 17 Oct 2026
  
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  DOI: 10.1016/j.celrep.2026.118155
  
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10565_2026_10199_MOESM4_ESM-html.html

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1. scibot 09 Oct 2026
  
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  DOI: 10.1007/s10565-026-10199-8
  
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α-Herpesviruses exploit host ssDNA gap prevention pathways for GC-rich genome replication and reactivation

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1. scibot 01 Oct 2026
  
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  DOI: 10.1016/j.celrep.2026.118044
  
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sciencedirect.com/science/article/pii/S2211124726011228
Sep 2026
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Mapping cell-type- and age-dependent neuronal vulnerability through genome-wide in vivo CRISPRi screens in the mouse brain

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1. scibot 11 Sep 2026
  
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  DOI: 10.1016/j.neuron.2026.08.006
  
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A microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome

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1. scibot 09 Sep 2026
  
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  DOI: 10.1016/j.chom.2026.08.011
  
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sciencedirect.com/science/article/pii/S1931312826003537
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IRX1 suppresses cervical squamous cell carcinoma progression by downregulating ACLY expression to inhibit lipid synthesis

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1. scibot 03 Sep 2026
  
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  DOI: 10.1016/j.isci.2026.117115
  
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Aug 2026
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PRDX1 drives colorectal cancer progression and immune microenvironment remodeling by facilitating PRMT5 nuclear translocation to activate Wnt/β-catenin signaling

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1. scibot 30 Aug 2026
  
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  DOI: 10.1016/j.ijbiomac.2026.154238
  
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BPS Publications

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1. scibot 28 Aug 2026
  
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  DOI: 10.1111/bph.70648
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70648
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ERO1L induces macrophage infiltration to potentiate KrasG12D and inflammation-induced pancreatic tumorigenesis via oxidative protein folding of CCL2

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1. scibot 19 Aug 2026
  
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  DOI: 10.1186/s13578-026-01601-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13479891/
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Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8+ T cell immunotherapy responses

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1. scibot 13 Aug 2026
  
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  DOI: 10.1016/j.xcrm.2026.102984
  
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sciencedirect.com/science/article/pii/S2666379126004015
Jul 2026
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Molecular basis of the HPV E7-ZER1 axis reveals a ligandable vulnerability in HPV-positive cancers

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1. scibot 30 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117740
  
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sciencedirect.com/science/article/pii/S2211124726008181
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DHODH is a synthetic lethal target in PIK3CA-mutant colorectal cancer

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1. scibot 26 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117719
  
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DNAJB9 promotes epithelial-mesenchymal transition in the nasal epithelium of chronic rhinosinusitis by enhancing TRIM22-mediated IκBα degradation

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1. scibot 18 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116681
  
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Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0523
  
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aacrjournals.org/cancerres/article/85/20/3930/766090/Exon-Skipping-of-Ste20-Like-Kinase-Enhances
54.241.53.176 54.241.53.176

The central precocious puberty-associated gene MKRN3 is a tumor suppressor regulating CSDE1 ubiquitination in ovarian cancer

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1. scibot 11 Jul 2026
  
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  DOI: 10.1038/s41389-026-00631-3
  
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54.241.53.176/a36ca0ef91d4255e2fc2ae0c27ccb022c218dd87/s41389-026-00631-3_reference-html.html
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FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer’s disease pathology

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1. scibot 08 Jul 2026
  
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  DOI: 10.1038/s44318-026-00818-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13324857/
Jun 2026
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Structural insights into histone mimicry by the small hepatitis delta antigen

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  DOI: 10.1016/j.jbc.2026.113252
  
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Targeting the macrophage mechanosensing regulator CKAP4 accelerates the inflammatory-to-proliferative transition in wound healing

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1. scibot 03 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117395
  
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May 2026
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USP52-RAB11FIP5 axis suppresses ferroptosis by repressing transferrin receptor recycling in head and neck squamous cell carcinoma

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1. scibot 30 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117467
  
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CDK6/4 inactivates BAP1 deubiquitinase destabilizing VHL to promote metastatic colonization in liver

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1. scibot 29 May 2026
  
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  DOI: 10.1186/s12943-026-02650-5
  
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S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

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1. scibot 13 May 2026
  
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  DOI: 10.1016/j.molcel.2026.04.016
  
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Apr 2026
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USP15 stabilizes c-Myc to drive sunitinib resistance by suppressing cuproptosis in clear cell renal cell carcinoma

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1. scibot 29 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117328
  
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Stabilizing MARCH7 as a ferro-guardian against ferroptosis

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1. scibot 29 Apr 2026
  
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  DOI: 10.1016/j.cell.2026.03.052
  
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Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.neuron.2026.03.035
  
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54.241.53.176 54.241.53.176

lin-et-al-2026-exercise-ameliorates-adipose-tissue-insulin-resistance-by-activating-the-lactate-gpr81-signaling-pathway-html.html

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1. scibot 21 Apr 2026
  
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  DOI: 10.1152/ajpendo.00321.2025
  
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54.241.53.176/a809efb51b41ea4d9d4ec968d70be26daee9aa88/lin-et-al-2026-exercise-ameliorates-adipose-tissue-insulin-resistance-by-activating-the-lactate-gpr81-signaling-pathway-html.html
54.241.53.176 54.241.53.176

1-s2.0-S2589004226011594-main-html.html

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1. scibot 18 Apr 2026
  
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  AB_11042321
  
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54.241.53.176 54.241.53.176

advs74967-sup-0001-suppmat.docx-html.html

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1. scibot 11 Apr 2026
  
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  AB_11042321
  
  DOI: 10.1002/advs.202522764
  
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HSPA2 modulates antiviral immunity by inhibiting TBK1 activation

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1. scibot 07 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117222
  
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TMEM145 is a principal component of outer hair cell stereocilia

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1. scibot 02 Apr 2026
  
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  DOI: 10.1016/j.neuron.2026.03.007
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13048287/
Mar 2026
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Bacterial 2′,3′-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication

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Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1

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FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

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USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses

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Unified phase separation drives DNA-induced inflammasome activation of the AIM2-like receptors

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Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes

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BPS Publications

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Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model

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USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis

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Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis

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ESM1 SUMOylation mediates bevacizumab resistance in ovarian cancer through ITGB1-FAK-driven angiogenesis

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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

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Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression

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Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML

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NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

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The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis

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paper2-html.html

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JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation

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Liprin-α1 enhances PHLDB3 oncogenic function in colorectal cancer via activation of mTORC2-AKT1 pathway

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s12974-025-03648-4_reference-html.html

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TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1

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Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma

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Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer

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The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

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Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells

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1-s2.0-S258900422502036X-main-html.html

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Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS

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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport

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Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells

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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

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41467_2025_56346_MOESM1_ESM-html.html

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SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia

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BPS Publications

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RFX2-BNIP3 axis-driven adaptive mitophagy promotes resistance to ACK1-targeted therapy in non-small cell lung cancer

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  DOI: 10.1038/s41388-025-03502-0
  
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Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma

1
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  RRID:AB_11
  
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Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners

1
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  DOI: 10.1016/j.xcrm.2025.102241
  
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Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7

1
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  DOI: 10.1016/j.jbc.2025.110502
  
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52.53.155.43 52.53.155.43

41467_2025_56346_MOESM1_ESM (1)-html.html

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Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis - ScienceDirect-html.html

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Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

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  DOI: 10.1126/sciadv.adu8422
  
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Jun 2025
52.53.155.43 52.53.155.43

kong-et-al-adipose-tissue-secreted-spz5-promotes-distal-tumor-progression-via-toll-6-mediated-hh-pathway-activation-in-html.html

2
1. scibot 28 Jun 2025
  
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  RRID: AB_11042321
  
  DOI: 10.1038/s44318-025-00489-y
  
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  AB_11042321
  
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Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

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  DOI: 10.1126/sciadv.adu8422
  
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Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila

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VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2

1
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  DOI: 10.1016/j.celrep.2025.115931
  
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Sigma-1R–Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS

1
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  DOI: 10.1016/j.nbd.2025.106992
  
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PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity

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  DOI: 10.1016/j.celrep.2025.115785
  
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ZBP1 senses splicing aberration through Z-RNA to promote cell death

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  DOI: 10.1016/j.molcel.2025.03.023
  
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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer

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  DOI: 10.1038/s41419-025-07624-x
  
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The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters

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  RRID:AB_11042321
  
  DOI: 10.1101/2025.03.25.645338
  
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biorxiv.org/content/10.1101/2025.03.25.645338v1
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LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia

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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

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  DOI: 10.1016/j.celrep.2025.115452
  
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Feb 2025
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PDF-html.html

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  DOI: 10.1158/0008-5472.can-24-1893
  
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STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma

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Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

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  DOI: 10.1016/j.devcel.2025.01.009
  
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Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy

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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

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  DOI: 10.1016/j.celrep.2024.115179
  
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YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies

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Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

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  DOI: 10.1016/j.celrep.2024.115033
  
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SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells

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Oct 2024
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Rift Valley fever virus coordinates the assembly of a programmable E3 ligase to promote viral replication

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HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma

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MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating USP18/VDAC2 pathway

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TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation

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  DOI: 10.1016/j.celrep.2024.114604
  
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Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma

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  DOI: 10.1016/j.cmet.2024.07.011
  
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May 2024
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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

1
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  DOI: 10.1016/j.molcel.2024.04.026
  
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Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity

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  DOI: 10.1016/j.celrep.2024.114255
  
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An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins

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Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects

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TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction

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Feb 2024
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AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ

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CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway

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Jan 2024
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Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells

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p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP

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OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB

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Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies

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Nov 2023
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JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia

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MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

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Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes

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CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis

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Deciphering the functional landscape of phosphosites with deep neural network

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PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ

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Jul 2023
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The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy

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Jun 2023
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QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

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Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer

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MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance

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USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis

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Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

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Apr 2023
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RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits

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Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication

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STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion

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PPT1 Regulation Of HSP90α Depalmitoylation Participates In The Pathogenesis Of Hyperandrogenism

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Dec 2022
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Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis

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Aug 2022
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S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway

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TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation

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Apr 2022
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Brown adipose tissue involution associated with progressive restriction in progenitor competence

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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

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The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy

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  DOI: 10.1016/j.isci.2022.104085
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8971941/
Mar 2022
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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

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  DOI: 10.1016/j.molcel.2022.02.033
  
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Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine

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  DOI: 10.1016/j.immuni.2022.03.001
  
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Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

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  DOI: 10.1016/j.isci.2022.103869
  
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Glycogen accumulation and phase separation drives liver tumor initiation

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RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis

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  DOI: 10.1016/j.cell.2021.09.008
  
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Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation

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1. scibot 24 Sep 2021
  
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nature.com/articles/s41401-021-00754-w
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Untitled document

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  DOI: 10.1016/j.cell.2018.11.004
  
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BPS Publications

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  DOI: 10.1111/bph.15490
  
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Jul 2021
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EGY3 mediates chloroplastic ROS homeostasis and promotes retrograde signaling in response to salt stress in Arabidopsis

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1. scibot 14 Jul 2021
  
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  DOI: 10.1016/j.celrep.2021.109384
  
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Jun 2021
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Bacterial RF3 senses chaperone function in co-translational folding

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  DOI: 10.1016/j.molcel.2021.05.016
  
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UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model

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1. scibot 15 May 2021
  
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  DOI: 10.1016/j.neuron.2021.04.023
  
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Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells

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  DOI: 10.1016/j.stem.2020.11.018
  
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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

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1. scibot 07 May 2021
  
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Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival

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1. scibot 10 Apr 2021
  
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  DOI: 10.3389/fimmu.2021.633796
  
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Nov 2020
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PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval

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  DOI: 10.1016/j.celrep.2020.108312
  
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Jan 2020
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Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation

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  RRID:AB_11042321
  
  DOI: 10.1016/j.celrep.2019.11.041
  
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Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism

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1. scibot 13 Jan 2020
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.chom.2019.10.014
  
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Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination

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1. scibot 13 Jan 2020
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.neuron.2019.02.018
  
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FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

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1. scibot 12 Jan 2020
  
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  RRID:AB_11042321
  
  DOI: 10.1016/j.devcel.2018.12.021
  
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sciencedirect.com/science/article/pii/S1534580718311171

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