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PHPT1/Ocnus negatively regulates the JAK/STAT pathway to control cell survival

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1. scibot 19 Sep 2026
  
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  DOI: 10.1016/j.isci.2026.117537
  
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sciencedirect.com/science/article/pii/S2589004226029160
Sep 2026
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The long non-coding RNA-encoded microprotein MKKS3 drives colorectal cancer chemoresistance

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1. scibot 12 Sep 2026
  
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  DOI: 10.1038/s12276-026-01817-w
  
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nature.com/articles/s12276-026-01817-w
Aug 2026
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Functional genomics in Xenopus identifies ARHGAP10 as a congenital heart disease and ciliopathy gene

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1. scibot 15 Aug 2026
  
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  DOI: 10.1016/j.isci.2026.117178
  
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Aggregation and propagation of TAF15 trigger neurodegeneration

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1. scibot 09 Aug 2026
  
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  DOI: 10.1016/j.neuron.2026.06.022
  
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Jul 2026
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Molecular basis of the HPV E7-ZER1 axis reveals a ligandable vulnerability in HPV-positive cancers

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1. scibot 30 Jul 2026
  
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Late endosome transport by RILP-RAB7A promotes dendrite arborization independently of degradation

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  DOI: 10.1523/JNEUROSCI.2214-25.2026
  
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DNAJB9 promotes epithelial-mesenchymal transition in the nasal epithelium of chronic rhinosinusitis by enhancing TRIM22-mediated IκBα degradation

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1. scibot 18 Jul 2026
  
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A cross-vertebrate brain protein interaction map identifies conserved neural and non-neural complexes

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1. scibot 17 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13372023/
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Profiling of terminating ribosomes reveals translational control at stop codons

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1. scibot 12 Jul 2026
  
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  DOI: 10.7554/eLife.109257
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13341110/
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Tryptophanol enhances nitrogen assimilation in marine diatoms

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1. scibot 11 Jul 2026
  
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  DOI: 10.1038/s41467-026-71191-8
  
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nature.com/articles/s41467-026-71191-8
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HDAC5 depletion promotes hyper-acetylation of FOXA1 and potentiates HIF1α transcriptional activation in pancreatic cancer

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1. scibot 10 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.022
  
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FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer’s disease pathology

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1. scibot 08 Jul 2026
  
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  DOI: 10.1038/s44318-026-00818-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13324857/
Jun 2026
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Centrosome linker protein CEP68 modulates cellular stress responses via nuclear condensate formation and HSP27 interaction

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1. scibot 24 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116491
  
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Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 signaling

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1. scibot 18 Jun 2026
  
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  DOI: 10.64898/2026.06.09.731146
  
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biorxiv.org/content/10.64898/2026.06.09.731146v1
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A mechanism of target mRNA selection and activity regulation in meiosis-related RBM46-MEIOC-YTHDC2 complex

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1. scibot 05 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.116234
  
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nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability

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1. scibot 05 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117495
  
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sciencedirect.com/science/article/pii/S2211124726005735
May 2026
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Farnesylation-driven KRAS phase separation promotes colon tumor growth

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.cell.2026.05.002
  
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The UFSP2-C1orf27 complex positions nascent GPCRs to the ufmylation system for ER export control

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.isci.2026.115707
  
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Apr 2026
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Importin α regulates ciliogenesis and cilia length with implications for Xenopus nephrogenesis

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1. scibot 30 Apr 2026
  
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  DOI: 10.1242/jcs.264441
  
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The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK

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1. scibot 30 Apr 2026
  
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  DOI: 10.1016/j.chembiol.2026.04.003
  
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Ubiquilin1 restricts influenza viral replication through trapping vRNP in the late endosomes

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1. scibot 29 Apr 2026
  
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Protocol for enhancing CRISPR-Cas9 genome editing using histone deacetylase inhibition and engineered virus-like particle delivery

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.xpro.2026.104493
  
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B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

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1. scibot 18 Apr 2026
  
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  DOI: 10.1016/j.cell.2026.03.039
  
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Mar 2026
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Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

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1. scibot 06 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117051
  
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Feb 2026
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BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes

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1. scibot 20 Feb 2026
  
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Translation elongation as a rate-limiting step of protein production

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  DOI: 10.1016/j.cels.2025.101490
  
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Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination

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2025.09.03.673267v1.full-html.html

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pmc.ncbi.nlm.nih.gov/articles/PMC12697282/
Jan 2026
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cxcl18b-defined transitional state-specific nitric oxide drives injury-induced Müller glia cell-cycle re-entry in the zebrafish retina

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  DOI: 10.7554/eLife.106274
  
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Diverse microtubule-binding repeats regulate TPX2 activities at distinct locations within the spindle

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  DOI: 10.1083/jcb.202404025
  
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1-s2.0-S2589004226000532-main-html.html

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Lactylation-driven nuclear RIG-I promoted by lactate transporter inhibitor suppresses DNA damage repair through inhibiting PARP1 activity

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  DOI: 10.1016/j.celrep.2025.116854
  
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Migrasome-driven mitocytosis relieves mitochondrial damage induced by chikungunya virus TF and 6K

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  DOI: 10.1016/j.hlife.2025.12.002
  
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UBE2O-mediated monoubiquitination licenses NLRP6 inflammasome activation in the intestine

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.chom.2025.12.009
  
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Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

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1. scibot 06 Jan 2026
  
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  DOI: 10.1096/fj.202503265R
  
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Dec 2025
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FAME-CRISPR improves CRISPR-Cas9 genome editing via HDAC inhibition and engineered virus-like particle delivery

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Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance

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IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation

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Reversal of diet-induced obesity by central insulin sensitizer FSTL1

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Cell-type-specific RNA polymerase II activity maps in intact tissues provide a gateway to mammalian gene regulatory mechanisms in vivo

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How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

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Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9

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Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS

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2025.09.03.673267v1.full-html.html

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KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1

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MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

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TM9SF3 is a Golgi-resident ATG8-binding protein essential for Golgi-selective autophagy

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Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis

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Sigma-1R–Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS

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A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment

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A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

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A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment

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A novel nonsense mutation of the glucocorticoid receptor gene causing glucocorticoid resistance with infertility

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Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and RILP

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1-s2.0-S2589004225006467-main-html.html

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Age-dependent glial heterogeneity and traumatic injury responses in a vertebrate brain structure

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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

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β-hydroxybutyrate facilitates mitochondrial-derived vesicle biogenesis and improves mitochondrial functions

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The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

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Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction

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Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine

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MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling

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Tak1 licenses mitochondrial transfer from astrocytes to POMC neurons to maintain glucose and cholesterol homeostasis

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Plausible, robust biological oscillations through allelic buffering

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Dephosphorylation of bZIP59 by PP2A ensures appropriate shade avoidance response in Arabidopsis

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A Zea genus-specific micropeptide controls kernel dehydration in maize

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ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma

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P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination

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Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division

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Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

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Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia

1
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Live-cell imaging of RNA Pol II and elongation factors distinguishes competing mechanisms of transcription regulation

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An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels

1
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Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance

1
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Cancer-associated endocrine cells participate in pancreatic carcinogenesis

1
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Atg8/LC3 controls systemic nutrient surplus signaling in flies and humans

1
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Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer

1
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LEUTX regulates porcine embryonic genome activation in somatic cell nuclear transfer embryos

1
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LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination

1
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Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity

1
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Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release

1
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Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes

1
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Epstein–Barr Virus BALF0/1 Subverts the Caveolin and ERAD Pathways to Target B-cell Receptor Complexes for Degradation

2
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Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis

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The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD

1
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A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice

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hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility

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Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin

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Grass carp reovirus VP56 and VP35 induce formation of viral inclusion bodies for replication

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Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis

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V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation

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Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP

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MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

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Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination

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Structural and biochemical insights into the interaction mechanism underlying HORMAD1 and its partner proteins

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Mammalian autophagosomes form from finger-like phagophores

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Beta cell primary cilia mediate somatostatin responsiveness via SSTR3

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C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress

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USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential

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PIIS221112472300952X-html.html

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LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs

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ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis

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Jul 2023
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A Proximity Labeling Strategy Enables Proteomic Analysis of Inter-organelle Membrane Contacts

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Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment

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An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation

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MYO10 regulates genome stability and cancer inflammation through mediating mitosis

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Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

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RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits

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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING

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Bub1 and Bub3 regulate metabolic adaptation via macrolipophagy in Drosophila

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Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting

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Plasmodium sporozoites require the protein B9 to invade hepatocytes

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CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons

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A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex

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Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation

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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity

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S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway

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The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice

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Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability

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Cholesterol determines the cytosolic entry and seeded aggregation of tau

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A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair

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ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function

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Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine

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Targeting HNRNPM inhibits cancer stemness and enhances antitumor immunity in Wnt-activated hepatocellular carcinoma

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A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h

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BPS Publications

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Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

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Deficiency of ER Ca2+ sensor STIM1 in AgRP neurons confers protection against dietary obesity

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Drosophila STING protein has a role in lipid metabolism

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PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

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A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress

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Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila

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Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

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The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity

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GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration

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Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons

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Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling

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A Vagal-NTS Neural Pathway that Stimulates Feeding

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Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway

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Bach1-induced suppression of angiogenesis is dependent on the BTB domain

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An oncopeptide regulates m 6 A recognition by the m 6 A reader IGF2BP1 and tumorigenesis

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Peroxisome Elevation Induces Stem Cell Differentiation and Intestinal Epithelial Repair

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DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State

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A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2

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An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis

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lncRNA Sensing of a Viral Suppressor of RNAi Activates Non-canonical Innate Immune Signaling in Drosophila

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Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish

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The Release of Adipose Stromal Cells from Subcutaneous Adipose Tissue Regulates Ectopic Intramuscular Adipocyte Deposition

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Untitled document

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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

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A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth

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