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Metformin hijacks AMPK-ERK1/2 signaling to trigger a pathogenic “selection trap” and thymic atrophy

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1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116762
  
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sciencedirect.com/science/article/pii/S2211124725015347
Dec 2025
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1-s2.0-S258900422502646X-main-html.html

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1. scibot 11 Dec 2025
  
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54.241.53.176/93de8e6290387b0a29b7a2c9729bf4f9de57ced1/1-s2.0-S258900422502646X-main-html.html
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Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.immuni.2025.11.018
  
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sciencedirect.com:5037/science/article/pii/S1074761325005205
Nov 2025
www.biorxiv.org www.biorxiv.org

Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL

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1. scibot 25 Nov 2025
  
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  DOI: 10.1101/2025.11.19.689204
  
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biorxiv.org/content/10.1101/2025.11.19.689204v2
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A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1

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1. scibot 18 Nov 2025
  
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  DOI: 10.1038/s41467-025-64939-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12615601/
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IL-2/IL-15 signaling induces NK cell production of FLT3LG augmenting anti-PD-1 immunotherapy

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1. scibot 06 Nov 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-1259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12582536/
Oct 2025
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USP14-mediated metabolic competition impairs CD8+ T cell immunosurveillance in hepatocellular carcinoma

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1. scibot 29 Oct 2025
  
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  DOI: 10.1073/pnas.2510576122
  
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pnas.org/doi/abs/10.1073/pnas.2510576122
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Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.xcrm.2025.102413
  
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sciencedirect.com/science/article/pii/S2666379125004860
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The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells

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1. scibot 08 Oct 2025
  
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sciencedirect.com/science/article/pii/S1074761325004194
Sep 2025
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Gut-derived metabolites drive Th17 cell pathogenicity in multiple sclerosis

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116326
  
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sciencedirect.com/science/article/pii/S2211124725010976
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Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.08.006
  
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sciencedirect.com/science/article/pii/S1074761325003693
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GD2TIF cells as a platform for single-dose and long-term delivery of biologics

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1. scibot 03 Sep 2025
  
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  DOI: 10.1038/s41467-025-63427-w
  
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nature.com/articles/s41467-025-63427-w
Aug 2025
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A vascular-associated fibroblastic cell controls pancreatic islet immunity

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1. scibot 29 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116189
  
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sciencedirect.com/science/article/pii/S221112472500960X
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Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells

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1. scibot 05 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116093
  
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sciencedirect.com/science/article/pii/S2211124725008642
Jul 2025
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
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Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.016
  
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sciencedirect.com/science/article/pii/S1074761325002857
Jun 2025
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De-coupling immune parameters and toxicity associated with IL-12 agonism

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115840
  
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sciencedirect.com/science/article/pii/S2211124725006114
May 2025
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A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.immuni.2025.05.003
  
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sciencedirect.com/science/article/pii/S1074761325002225
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115733
  
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sciencedirect.com/science/article/pii/S2211124725005042
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Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.027
  
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sciencedirect.com/science/article/pii/S1074761325001906
Mar 2025
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Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.cell.2025.02.014
  
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sciencedirect.com/science/article/pii/S0092867425001990
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TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness

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1. scibot 06 Mar 2025
  
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  DOI: 10.1038/s41421-024-00766-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11880246/
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.007
  
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sciencedirect.com/science/article/pii/S107476132500072X
Feb 2025
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Potentiating anti-tumor immunity by re-engaging immune synapse molecules

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101975
  
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sciencedirect.com/science/article/pii/S2666379125000485
Jan 2025
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CAR T cells, CAR NK cells, and CAR macrophages exhibit distinct traits in glioma models but are similarly enhanced when combined with cytokines

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1. scibot 31 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2025.101931
  
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sciencedirect.com/science/article/pii/S2666379125000047
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Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer

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1. scibot 31 Jan 2025
  
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  DOI: 10.1016/j.ccell.2025.01.001
  
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sciencedirect.com/science/article/pii/S1535610825000194
Dec 2024
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Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells

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1. scibot 20 Dec 2024
  
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  DOI: 10.1126/scisignal.adi8753
  
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science.org/doi/10.1126/scisignal.adi8753
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A double-edged sword role of IFN-γ producing iNKT cells in sepsis: persistent suppression of Treg cell formation in a Nr4a1 dependent manner

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111462
  
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sciencedirect.com/science/article/pii/S2589004224026890
Sep 2024
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Induction of immortal-like and functional CAR T cells by defined factors

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1. scibot 27 Sep 2024
  
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  DOI: 10.1084/jem.20232368
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10965394/
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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cmet.2024.08.005
  
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sciencedirect.com/science/article/pii/S1550413124003322
Aug 2024
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Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114636
  
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sciencedirect.com/science/article/pii/S2211124724009860
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2017.10.006
  
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sciencedirect.com/science/article/pii/S1550413117306186
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Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell

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1. scibot 02 Aug 2024
  
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  DOI: 10.1038/s41598-022-24132-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9669047/
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1. scibot 02 Aug 2024
  
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  RRID: AB_1107624
  
  DOI: 10.21203/rs.3.rs-1862066/v1
  
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researchsquare.com/article/rs-7216019/'https://www.researchsquare.com/article/rs-7216019/v1
Jul 2024
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MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells

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1. scibot 31 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114565
  
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The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

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A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice

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May 2024
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T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells

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One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade

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Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

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Chemoradiotherapy-induced ACKR2+ tumor cells drive CD8+ T cell senescence and cervical cancer recurrence

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A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification

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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs

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The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis

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Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade

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cd-22-1301-html.html

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Induction of immortal-like and functional CAR-T cells by defined factors

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One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

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An essential role for miR-15/16 in Treg suppression and restriction of proliferation

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Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation

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Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma

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Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection

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Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α

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Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation

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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

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Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut

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Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance

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Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity

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P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy

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Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell

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Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation

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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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Quantitative Increase in T Regulatory Cells Enhances Bone Remodeling in Osteogenesis Imperfecta

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Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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Jun 2022
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Neuropilin-1 cooperates with PD-1 in CD8+ T-cells predicting outcomes in melanoma patients treated with anti-PD1

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Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function

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  DOI: 10.1158/0008-5472.CAN-21-3155
  
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Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization

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Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

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Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

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Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation

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PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory

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Delivery of membrane impermeable molecules to primary mouse T lymphocytes

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MicroRNA-10a Negatively Regulates CD4+ T Cell IL-10 Production through Suppression of Blimp1

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Untitled document

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The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility

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Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration

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The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

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Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

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Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

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CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23

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Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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cell.com/cell/fulltext/S0092-8674(20)31526-9
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Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

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In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

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A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

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BPS Publications

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Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity

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The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation

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Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy

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  anti-CD28
  
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Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

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Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

1
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Serine Catabolism Feeds NADH when Respiration Is Impaired

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High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation

1
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miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

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Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

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Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

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A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

1
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  DOI: 10.1016/j.immuni.2019.06.023
  
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Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis

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  DOI: 10.1016/j.celrep.2019.09.002
  
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Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

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  DOI: 10.1016/j.celrep.2019.07.044
  
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currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com

Untitled document

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  DOI: 10.1002/cpim.62
  
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Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R−STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity

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  DOI: 10.1016/j.immuni.2018.10.010
  
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Untitled document

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Untitled document

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  DOI: 10.1016/j.immuni.2018.12.014
  
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Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.03.031
  
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Untitled document

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  DOI: 10.1016/j.immuni.2018.12.020
  
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  DOI: 10.1016/j.ebiom.2019.04.045
  
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Untitled document

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Nov 2018
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Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens

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1. scibot 05 Nov 2018
  
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Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells

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1. scibot 05 Nov 2018
  
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Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

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Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production

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T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation

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1. scibot 05 Nov 2018
  
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Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism

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1. scibot 05 Nov 2018
  
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation

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1. scibot 08 Nov 2017
  
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