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May 2026
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ST8Sia6-dependent glycosylation restrains gut inflammation and pathogenic Th1 and Th17 programs

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IL-1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma

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  DOI: 10.1158/2326-6066.CIR-25-0651
  
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aacrjournals.org/cancerimmunolres/article/14/5/751/784456/IL1R2-Deficiency-Unleashes-Neutrophil-Mediated
Apr 2026
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IFNγ-induced PD-L1+MHC II+ macrophages and Tim-3+ tumor-reactive CD8+ T cells predict a response to anti-PD-1 therapy in tumor-bearing mice

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aacrjournals.org/cancerimmunolres/article/13/12/2004/768334/IFN-Induced-PD-L1-MHCII-Macrophages-and-Tim-3
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Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions

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Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment

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Bach2 antagonizes leukotriene B4-Ltb4r1-JunB signaling to constrain Tfh13 cell differentiation

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sciencedirect.com/science/article/pii/S2211124726002986
Mar 2026
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Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity

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Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity

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RORγt Inhibition Reduces Pro-Tumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12288671/
Feb 2026
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BPS Publications

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  DOI: 10.1111/bph.70316
  
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Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development

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pmc.ncbi.nlm.nih.gov/articles/PMC12869356/
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Stochasticity in cancer immunotherapy stems from rare but functionally critical Spark T cells

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  DOI: 10.1016/j.cell.2025.12.026
  
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sciencedirect.com/science/article/pii/S0092867425014394
Jan 2026
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IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

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1. scibot 23 Jan 2026
  
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The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation

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  DOI: 10.1016/j.isci.2025.114267
  
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sciencedirect.com/science/article/pii/S2589004225025283
Dec 2025
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Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.stem.2025.12.005
  
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sciencedirect.com/science/article/pii/S1934590925004394
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Gut microbiota promotes immune tolerance at the maternal-fetal interface

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Nov 2025
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Virus envelope glycoprotein targeting bispecific T cell engager protects mice from lethal severe fever with thrombocytopenia virus infection

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Oct 2025
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A recombinant Cedar virus preclinical model that recapitulates neurological features of henipavirus disease

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Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

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Sep 2025
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S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis

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E. coli-activated cellular circuit restrains intestinal inflammatory microbiota-specific T cells and protects against colitis

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Gut-derived metabolites drive Th17 cell pathogenicity in multiple sclerosis

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1-s2.0-S2589004225018322-main-html.html

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Aug 2025
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Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ

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A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma

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Jul 2025
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Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

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Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity

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Jun 2025
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Maternal vitamin D regulates the metabolic rearrangement of offspring CD4+ T cells in response to intestinal inflammation

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Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade

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May 2025
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Trajectories of macrophage ontogeny and reprogramming in cancer

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Bone metastases diminish extraosseous response to checkpoint blockade immunotherapy through osteopontin-producing osteoclasts

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Apr 2025
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Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection

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Feb 2025
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Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

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  DOI: 10.1084/jem.20231486
  
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Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infection

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  DOI: 10.1371/journal.ppat.1012906
  
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1-s2.0-S2589004225002354-main-html.html

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Jan 2025
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Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer

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  DOI: 10.1016/j.ccell.2025.01.001
  
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Nov 2024
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Meningeal neutrophil immune signaling influences behavioral adaptation following threat

1
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  DOI: 10.1016/j.neuron.2024.10.018
  
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Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity

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Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus

1
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Aug 2024
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

1
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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

1
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Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

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May 2024
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Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng

2
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Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy

1
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The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells

1
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A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification

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Apr 2024
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Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

2
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Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction

1
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Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection

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Mar 2024
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Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy

2
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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

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Feb 2024
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The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis

1
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Jan 2024
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Fc-fused IL-7 provides broad antiviral effects against respiratory virus infections through IL-17A-producing pulmonary innate-like T cells

1
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  DOI: 10.1016/j.xcrm.2023.101362
  
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Bispecific dendritic-T cell engager potentiates anti-tumor immunity

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  DOI: 10.1016/j.cell.2023.12.011
  
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Dec 2023
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More time to kill: a longer liver stage increases T cell-mediated protection against pre-erythrocytic malaria

1
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  DOI: 10.1016/j.isci.2023.108489
  
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Nov 2023
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Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses

1
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FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

1
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  DOI: 10.1101/2023.11.01.563607
  
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Oct 2023
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Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease

1
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Jul 2023
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A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence

1
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A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

1
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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

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Jun 2023
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Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation

1
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RORψt+CD4+ T cells promote IL-23R-mediated neuronal cell apoptosis in the central nervous system

1
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  DOI: 10.1101/2023.04.17.537133
  
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Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

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  DOI: 10.1038/s41467-023-38899-3
  
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nature.com/articles/s41467-023-38899-3
May 2023
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Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice

1
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  DOI: 10.1016/j.isci.2023.106774
  
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Apr 2023
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Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis

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A neutrophil response linked to tumor control in immunotherapy

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Mar 2023
europepmc.org europepmc.org

mRNAs encoding IL-12 and a decoy-resistant variant of IL-18 synergize to engineer T cells for efficacious intratumoral adoptive immunotherapy

1
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  DOI: 10.1016/j.xcrm.2023.100978
  
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Jan 2023
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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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Opioid-induced fragile-like regulatory T cells contribute to withdrawal

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GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology

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Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

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Immunoediting instructs tumor metabolic reprogramming to support immune evasion

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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

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Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis

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Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

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Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis

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Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis

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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis

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Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function

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Newly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection

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ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection

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Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites

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Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

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The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell

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IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells

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Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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Cold exposure protects from neuroinflammation through immunologic reprogramming

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Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation

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Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza

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Delivery of membrane impermeable molecules to primary mouse T lymphocytes

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MicroRNA-10a Negatively Regulates CD4+ T Cell IL-10 Production through Suppression of Blimp1

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Untitled document

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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility

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A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant

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Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

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Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

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Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells

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Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium

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The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation

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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23

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Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis

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Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity

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The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation

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Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

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Foxo3 Promotes the Differentiation and Function of Follicular Helper T Cells

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Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics

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Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis

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Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

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Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products

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Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

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Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells

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Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

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Untitled document

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Untitled document

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  DOI: 10.1016/j.immuni.2018.12.014
  
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Untitled document

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Nov 2018
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Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy

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Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells

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Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

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Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production

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Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors

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TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

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Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment

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Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever

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The Transcription Factor T-bet Limits Amplification of Type I IFN Transcriptome and Circuitry in T Helper 1 Cells

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Annotators

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Annotators

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Annotators

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Annotators

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Annotators

URL

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Annotators