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The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathology

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1. scibot 17 Oct 2026
  
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  DOI: 10.1016/j.molcel.2026.09.039
  
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sciencedirect.com/science/article/pii/S1097276526007045
Oct 2026
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Lipid-engineered antibody-based therapeutics target inflamed joints and lymph nodes to enhance rheumatoid arthritis treatment

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1. scibot 09 Oct 2026
  
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  DOI: 10.1016/j.xcrm.2026.103094
  
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Host metadherin coordinates hepatic lipid metabolism and CD8+ T cell immunity to promote tumor progression

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1. scibot 01 Oct 2026
  
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  DOI: 10.1016/j.cmet.2026.08.003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13623212/
Sep 2026
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CD4 T cells convert transient responses to KRAS inhibition to durable remissions in pancreatic cancer

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1. scibot 27 Sep 2026
  
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  DOI: 10.1016/j.cell.2026.08.045
  
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sciencedirect.com/science/article/pii/S0092867426010184
Aug 2026
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Host metadherin coordinates hepatic lipid metabolism and CD8+ T cell immunity to promote tumor progression

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1. scibot 31 Aug 2026
  
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Circulating memory-phenotype CD4+ T cells rapidly accumulate in the ischemic gut to exacerbate tissue injury in an innate manner

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1. scibot 01 Aug 2026
  
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  DOI: 10.1016/j.celrep.2026.117745
  
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sciencedirect.com/science/article/pii/S2211124726008235
Jun 2026
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Mrgpra2+ neutrophils integrate infection-derived signals to trigger NET-mediated antimicrobial defense in bone marrow

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117579
  
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sciencedirect.com/science/article/pii/S2211124726006571
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Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.cell.2026.05.036
  
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sciencedirect.com/science/article/pii/S0092867426006367
May 2026
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Microbial phosphoketolase promotes histone lactylation to improve anti-TNF therapy efficacy in inflammatory bowel disease

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1. scibot 14 May 2026
  
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sciencedirect.com/science/article/pii/S1550413126001506
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Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer

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1. scibot 08 May 2026
  
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  DOI: 10.1016/j.ccell.2026.04.005
  
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sciencedirect.com/science/article/pii/S1535610826002163
Dec 2025
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Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.stem.2025.12.005
  
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sciencedirect.com/science/article/pii/S1934590925004394
Sep 2025
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Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116223
  
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sciencedirect.com/science/article/pii/S2211124725009945
Aug 2025
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T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-0416
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11790381/
Jul 2025
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Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102257
  
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Naturalized immune responses are stable over years in a colony of laboratory mice with wild-derived microbiota

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.07.004
  
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sciencedirect.com/science/article/pii/S1074761325003139
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.027
  
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sciencedirect.com/science/article/pii/S0092867425007287
Jun 2025
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RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.cmet.2025.05.014
  
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sciencedirect.com/science/article/pii/S1550413125002943
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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2326-6066.cir-24-0797
  
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52.53.155.43/714962b4df611138463d94a4796d134a4c0f1b27/pdf-html.html
May 2025
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A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

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1. scibot 19 May 2025
  
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  DOI: 10.1038/s44318-025-00412-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
Feb 2025
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Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infection

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1. scibot 14 Feb 2025
  
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  DOI: 10.1371/journal.ppat.1012906
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11813105/
Nov 2024
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Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity

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1. scibot 20 Nov 2024
  
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  DOI: 10.1016/j.celrep.2024.114855
  
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sciencedirect.com/science/article/pii/S2211124724012063
Sep 2023
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Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma

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1. scibot 28 Sep 2023
  
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  DOI: 10.1016/j.xcrm.2023.101188
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10518627/
Jul 2023
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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

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1. scibot 07 Jul 2023
  
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  DOI: 10.1016/j.cell.2023.06.002
  
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May 2023
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The enteric nervous system relays psychological stress to intestinal inflammation

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1. scibot 26 May 2023
  
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  DOI: 10.1016/j.cell.2023.05.001
  
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Feb 2023
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Additive efficacy of a bispecific anti–TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis

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1. scibot 06 Feb 2023
  
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  DOI: 10.1126/scitranslmed.abq4419
  
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science.org/doi/10.1126/scitranslmed.abq4419
Aug 2022
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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

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1. scibot 13 Aug 2022
  
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  DOI: 10.1016/j.cell.2016.07.019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5002269/
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CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder

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1. scibot 04 Aug 2022
  
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  DOI: 10.1016/j.cmet.2022.07.005
  
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sciencedirect.com/science/article/pii/S1550413122003047
Apr 2022
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TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells

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1. scibot 14 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110657
  
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Feb 2022
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Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

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1. scibot 23 Feb 2022
  
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  DOI: 10.1016/j.immuni.2022.01.013
  
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sciencedirect.com/science/article/pii/S1074761322000425
Dec 2021
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The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota

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1. scibot 09 Dec 2021
  
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  DOI: 10.1016/j.xcrm.2021.100464
  
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Nov 2021
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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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1. scibot 24 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.110021
  
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sciencedirect.com/science/article/pii/S2211124721015035
Sep 2021
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Vaccination induces rapid protection against bacterial pneumonia via training alveolar macrophage in mice

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1. scibot 25 Sep 2021
  
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  DOI: 10.7554/eLife.69951
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8455131/
Aug 2021
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Untitled document

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1. scibot 09 Aug 2021
  
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  DOI: 10.1016/j.celrep.2018.11.047
  
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sciencedirect.com/science/article/pii/S2211124718318102
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Untitled document

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1. scibot 09 Aug 2021
  
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  DOI: 10.1016/j.chom.2018.09.015
  
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sciencedirect.com/science/article/pii/S1931312818304992
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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

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1. scibot 06 Aug 2021
  
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  DOI: 10.1016/j.cell.2016.07.019
  
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sciencedirect.com/science/article/pii/S0092867416309266
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Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants

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1. scibot 02 Aug 2021
  
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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

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TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling

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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

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Metabolic stress drives sympathetic neuropathy within the liver

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Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon

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  DOI: 10.1007/s13238-021-00835-w
  
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Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis

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Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury

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CD4+ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection

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Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

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Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

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Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

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TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity

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Untitled document

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Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice

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Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

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Nov 2017
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