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102 Matching Annotations

Sep 2026
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Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

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Jul 2026
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B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection

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Jun 2026
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Cancer-associated fibroblast subtypes differentially modulate natural killer cells in cancer

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Type I interferon signaling in hematopoietic cells impairs neutrophil antibacterial function in the middle ear during viral co-infection

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May 2026
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Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit

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Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion

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Maternal helminths rewire the microbiota to promote offspring antiviral immunity

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TCF1+CD4+ T cells and microglia co-orchestrate tertiary lymphoid structures to enhance prognosis and immunotherapy in non-small cell lung cancer with brain metastases

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IL-1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma

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Apr 2026
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E-cadherin expression promotes tumor growth via KLRG1-dependent pathways

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Sialic acid cis-ligand dynamics modulate Siglec-7 and -9 function and affect Siglec-7/9 co-blockade to potentiate natural killer cell anti-tumor activity

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1. scibot 07 Apr 2026
  
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Mar 2026
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Lipid nanoparticle used in mRNA vaccine promotes tumor metastasis in mouse model via mtDNA-induced neutrophil activation and NETosis

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1. scibot 31 Mar 2026
  
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Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.devcel.2026.02.020
  
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Feb 2026
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dzierlega-et-al-2026-neutrophil-derived-reactive-oxygen-species-mediate-doxorubicin-induced-cardiotoxicity-and-skeletal-html.html

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Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC

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Heterogeneity and plasticity of the naive CD4+ T cell compartment

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  DOI: 10.1016/j.celrep.2026.116980
  
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Jan 2026
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Preclinical characterisation of the protective capacity of an anti-nucleoprotein hRSV monoclonal antibody

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.ebiom.2025.106104
  
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Dec 2025
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IGF2BP1 fosters an immunosuppressive tumor microenvironment in high-risk neuroblastoma, contributing to their resistance to immunotherapy

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1. scibot 06 Dec 2025
  
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  DOI: 10.1080/2162402X.2025.2584408
  
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IGF2BP1 fosters an immunosuppressive tumor microenvironment in high-risk neuroblastoma, contributing to their resistance to immunotherapy

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Nov 2025
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IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy

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An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma

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A monoclonal antibody that inhibits the shedding of CD16a and CD16b and promotes antibody-dependent cellular cytotoxicity against tumors

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  DOI: 10.1038/s41467-025-64862-5
  
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IL-2/IL-15 signaling induces NK cell production of FLT3LG augmenting anti-PD-1 immunotherapy

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  DOI: 10.1158/2326-6066.CIR-24-1259
  
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Oct 2025
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Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance

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Aug 2025
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Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance

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CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases

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May 2025
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IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer

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  DOI: 10.1016/j.isci.2025.112639
  
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Interferon-γ and IL-27 positively regulate type 1 regulatory T cell development during adaptive tolerance

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  DOI: 10.1016/j.isci.2025.112308
  
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Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B

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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

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Apr 2025
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KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway

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  DOI: 10.1016/j.celrep.2025.115595
  
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Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection

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  DOI: 10.1016/j.celrep.2025.115528
  
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Mar 2025
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Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract

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  DOI: 10.1101/2025.03.05.639198
  
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Nov 2024
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Tumor stage-driven disruption of NK cell maturation in human and murine tumors

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1. scibot 26 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111233
  
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Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy

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A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies

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Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium

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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

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MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells

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A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML

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Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

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Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite

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Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng

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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

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IGSF8 is an innate immune checkpoint and cancer immunotherapy target

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Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis

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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

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Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness

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Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells

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ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures

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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

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Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses

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Aug 2023
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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

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Membrane-localized neoantigens predict the efficacy of cancer immunotherapy

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Jun 2023
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ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression

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Vaccine elicitation and structural basis for antibody protection against alphaviruses

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May 2023
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Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population

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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

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Apr 2023
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An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses

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Macrophage CD5L is a target for cancer immunotherapy

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Mar 2023
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Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

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Jan 2023
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Neutrophil-activating therapy for the treatment of cancer

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The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice

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Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

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The ectromelia virus virulence factor C15 facilitates early viral spread by inhibiting NK cell contact

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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

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mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment

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Mar 2022
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Type 1 innate lymphoid cells regulate the onset of Toxoplasma gondii-induced neuroinflammation

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Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti–PD-1/PD-L1 Agents

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Sequential modulation of the Wnt/β-catenin signaling pathway enhances tumor-intrinsic MHC I expression and tumor clearance

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Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

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Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza

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Live Imaging of SARS-CoV-2 Infection in Mice Reveals that Neutralizing Antibodies Require Fc Function for Optimal Efficacy

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Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

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Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells

1
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  InVivoMAb mouse IgG2a isotype clone C1.18.4
  
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Untitled document

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Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA

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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

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  DOI: 10.1016/j.stem.2021.04.011
  
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TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate

1
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  DOI: 10.1016/j.cell.2020.05.049
  
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Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

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Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling

1
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  RRID:AB_1107771
  
  DOI: 10.1016/j.immuni.2017.10.016
  
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cell.com/immunity/abstract/S1074-7613(17)30471-5
Jan 2020
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Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment

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Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice

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Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

1
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Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

1
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cell.com/cell-reports/fulltext/S2211-1247(19)30571-6
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Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

1
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  RRID:AB_1107771
  
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Nov 2018
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Untitled document

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Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

1
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Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

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Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling

1
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Nov 2017
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Evidence for Pro-angiogenic Functions of VEGF-Ax

1
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