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    LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
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    1. scibot 20 Aug 2024
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    sciencedirect.com/science/article/pii/S0092867424007761
  3. Jul 2024
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    Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor
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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00228-2
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    Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function
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    1. scibot 23 Jul 2024
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    biorxiv.org/content/10.1101/2024.07.16.603756v1
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    PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies
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    sciencedirect.com/science/article/pii/S266637912400363X
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    A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
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    sciencedirect.com/science/article/pii/S1550413124002353
  8. Jun 2024
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    Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
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    sciencedirect.com/science/article/pii/S0092867424004926
  10. May 2024
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    Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation
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    sciencedirect.com/science/article/pii/S1074761324002279
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    Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity
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    sciencedirect.com/science/article/pii/S2451945624001673
  13. Apr 2024
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    Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary
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    aacrjournals.org/cancerdiscovery/article/13/12/2610/731625/Spatial-and-Temporal-Mapping-of-Breast-Cancer-Lung
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    1. scibot 11 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724004169
  16. Feb 2024
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    UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
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    1. scibot 28 Feb 2024
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    sciencedirect.com/science/article/pii/S1097276524000911
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    Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity
    2
    1. scibot 21 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001244
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    Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment
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    1. scibot 16 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001256
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    An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL
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    sciencedirect.com/science/article/pii/S2666379124000442
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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    1. scibot 06 Feb 2024
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    sciencedirect.com/science/article/pii/S1550413124000068
  22. Dec 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
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    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.immuni.2023.11.005

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    sciencedirect.com/science/article/pii/S1074761323004879
  24. 52.53.155.43 52.53.155.43
    cd-23-0299-html.html
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    52.53.155.43/2b6c279d82b7a0e0d491057f5790a1189e93077e/cd-23-0299-html.html
  25. Nov 2023
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells
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    1. scibot 18 Nov 2023
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      DOI: 10.3390/cells12212558

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    ncbi.nlm.nih.gov/pmc/articles/PMC10649679/
  27. Sep 2023
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    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
    1
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    sciencedirect.com/science/article/pii/S2666379123003737
  29. Aug 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for the isolation of mouse senescence-associated CD4+ T cells using flow cytometry and functional assays
    1
    1. scibot 10 Aug 2023
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      DOI: 10.1016/j.xpro.2023.102472

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    ncbi.nlm.nih.gov/pmc/articles/PMC10400959/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Five inhibitory receptors display distinct vesicular distributions in T cells
    1
    1. scibot 03 Aug 2023
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      DOI: 10.1101/2023.07.21.550019

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    ncbi.nlm.nih.gov/pmc/articles/PMC10370166/
  32. Jul 2023
  33. www.sciencedirect.com www.sciencedirect.com
    QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations
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    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112828

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    sciencedirect.com/science/article/pii/S2211124723008392
  34. Jun 2023
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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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    sciencedirect.com/science/article/pii/S107476132300225X
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    Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow
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    1. scibot 03 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112580

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    sciencedirect.com/science/article/pii/S2211124723005910
  37. May 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    1. scibot 27 May 2023
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    sciencedirect.com/science/article/pii/S1535610823001423
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    Asymmetric cell division safeguards memory CD8 T cell development
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    1. scibot 13 May 2023
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      DOI: 10.1016/j.celrep.2023.112468

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    sciencedirect.com/science/article/pii/S2211124723004795
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    cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity
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    1. scibot 11 May 2023
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    sciencedirect.com/science/article/pii/S1074761323001735
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    Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion
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    1. scibot 06 May 2023
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      DOI: 10.1016/j.canlet.2023.216208

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    sciencedirect.com/science/article/pii/S0304383523001593
  42. Mar 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation
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    sciencedirect.com/science/article/pii/S2211124723002619
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    Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions
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      DOI: 10.1016/j.celrep.2023.112153

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    sciencedirect.com/science/article/pii/S221112472300164X
  45. Jan 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
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      DOI: 10.1158/2159-8290.CD-21-0003

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    ncbi.nlm.nih.gov/pmc/articles/PMC9401506/
  47. Nov 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy
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      DOI: 10.1016/j.celrep.2022.111647

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    sciencedirect.com/science/article/pii/S2211124722015182
  49. Sep 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction
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    sciencedirect.com/science/article/pii/S2666166722006086
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    cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells
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      DOI: 10.1016/j.celrep.2022.111373

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    sciencedirect.com/science/article/pii/S2211124722012050
  52. Aug 2022
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    Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation
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      DOI: 10.1016/j.cmet.2022.08.003

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    sciencedirect.com/science/article/pii/S1550413122003461
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    Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation
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    1. scibot 23 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111193

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    sciencedirect.com/science/article/pii/S2211124722010105
  55. Jun 2022
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    Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
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      DOI: 10.1016/j.ccell.2022.06.001

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    sciencedirect.com/science/article/pii/S1535610822002318
  57. Apr 2022
  58. www.sciencedirect.com www.sciencedirect.com
    Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
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    1. scibot 13 Apr 2022
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      DOI: 10.1016/j.immuni.2022.03.013

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    sciencedirect.com/science/article/pii/S1074761322001364
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    Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
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  60. Mar 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes
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      DOI: 10.1016/j.isci.2022.104021

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  62. www.sciencedirect.com www.sciencedirect.com
    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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  63. Jan 2022
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Bivalent Nanoparticle Vaccine Exhibits Potent Cross-protection against the Variants of SARS-CoV-2
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  65. Dec 2021
  66. www.sciencedirect.com www.sciencedirect.com
    Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential
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  67. Nov 2021
  68. www.sciencedirect.com www.sciencedirect.com
    Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function
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  70. Sep 2021
  71. www.sciencedirect.com www.sciencedirect.com
    A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells
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  72. Jul 2021
  73. www.sciencedirect.com www.sciencedirect.com
    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
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      Ultra-LEAF Purified anti-mouse CD28

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  74. Apr 2021
  75. www.sciencedirect.com www.sciencedirect.com
    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
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  76. Mar 2021
  77. www.sciencedirect.com www.sciencedirect.com
    Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
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  78. Dec 2020
  79. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses
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  80. Sep 2020
  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Heparin affects the induction of regulatory T cells independent of anticoagulant activity and suppresses the allogeneic immune responses
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    onlinelibrary.wiley.com/doi/10.1111/cei.13480
  82. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response
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    1. scibot 16 Sep 2020
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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      RRID:AB_11147170

      DOI: 10.1016/j.immuni.2020.04.014

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  84. Jan 2020
  85. www.cell.com www.cell.com
    STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth
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      RRID:AB_11147170

      DOI: 10.1016/j.cmet.2019.10.013

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    cell.com/cell-metabolism/fulltext/S1550-4131(19)30604-7
  86. www.sciencedirect.com www.sciencedirect.com
    Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells
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      RRID:AB_11147170

      DOI: 10.1016/j.cell.2019.07.044

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  87. Nov 2018
  88. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S2211124718310854