56 Matching Annotations
  1. Last 7 days
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    LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
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    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.cell.2024.07.016

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    sciencedirect.com/science/article/pii/S0092867424007761
  3. Jul 2024
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    Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor
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    1. scibot 30 Jul 2024
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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00228-2
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    Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function
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    1. scibot 23 Jul 2024
      RRID:AB_11149115

      DOI: 10.1101/2024.07.16.603756

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    biorxiv.org/content/10.1101/2024.07.16.603756v1
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    PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies
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    1. scibot 17 Jul 2024
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    sciencedirect.com/science/article/pii/S266637912400363X
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    A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
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    1. scibot 12 Jul 2024
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    sciencedirect.com/science/article/pii/S1550413124002353
  8. Jun 2024
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    Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
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    1. scibot 05 Jun 2024
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    sciencedirect.com/science/article/pii/S0092867424004926
  10. May 2024
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    Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation
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    1. scibot 21 May 2024
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    sciencedirect.com/science/article/pii/S1074761324002279
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    Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity
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    1. scibot 17 May 2024
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      DOI: 10.1016/j.chembiol.2024.04.005

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    sciencedirect.com/science/article/pii/S2451945624001673
  13. Apr 2024
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    Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary
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    1. scibot 19 Apr 2024
      RRID:AB_11149115

      DOI: 10.1158/2159-8290.CD-23-0299

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    aacrjournals.org/cancerdiscovery/article/13/12/2610/731625/Spatial-and-Temporal-Mapping-of-Breast-Cancer-Lung
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114088

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    sciencedirect.com/science/article/pii/S2211124724004169
  16. Feb 2024
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    UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
    1
    1. scibot 28 Feb 2024
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    sciencedirect.com/science/article/pii/S1097276524000911
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    An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL
    1
    1. scibot 14 Feb 2024
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      DOI: 10.1016/j.xcrm.2024.101421

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    sciencedirect.com/science/article/pii/S2666379124000442
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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    1. scibot 06 Feb 2024
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    sciencedirect.com/science/article/pii/S1550413124000068
  20. Dec 2023
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    Machine learning analysis of the T cell receptor repertoire identifies sequence features of self-reactivity
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.cels.2023.11.004

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    sciencedirect.com/science/article/pii/S2405471223003277
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    MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy
    1
    1. scibot 01 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113452

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    sciencedirect.com/science/article/pii/S221112472301464X
  23. 52.53.155.43 52.53.155.43
    cd-23-0299-html.html
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      DOI: 10.1158/2159-8290.cd-23-0299

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    52.53.155.43/2b6c279d82b7a0e0d491057f5790a1189e93077e/cd-23-0299-html.html
  24. Nov 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells
    1
    1. scibot 18 Nov 2023
      RRID:AB_11149115

      DOI: 10.3390/cells12212558

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    ncbi.nlm.nih.gov/pmc/articles/PMC10649679/
  26. Oct 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113180

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    sciencedirect.com/science/article/pii/S2211124723011920
  28. Sep 2023
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    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
    1
    1. scibot 30 Sep 2023
      RRID:AB_11149115

      DOI: 10.1016/j.xcrm.2023.101206

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    sciencedirect.com/science/article/pii/S2666379123003737
  30. Aug 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Five inhibitory receptors display distinct vesicular distributions in T cells
    1
    1. scibot 03 Aug 2023
      RRID:AB_11149115

      DOI: 10.1101/2023.07.21.550019

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    ncbi.nlm.nih.gov/pmc/articles/PMC10370166/
  32. Jul 2023
  33. www.sciencedirect.com www.sciencedirect.com
    QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations
    1
    1. scibot 21 Jul 2023
      RRID:AB_11149115

      DOI: 10.1016/j.celrep.2023.112828

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    sciencedirect.com/science/article/pii/S2211124723008392
  34. Jun 2023
  35. www.sciencedirect.com www.sciencedirect.com
    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.immuni.2023.05.008

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    sciencedirect.com/science/article/pii/S107476132300225X
  36. www.sciencedirect.com www.sciencedirect.com
    Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow
    1
    1. scibot 03 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112580

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    sciencedirect.com/science/article/pii/S2211124723005910
  37. May 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    1. scibot 27 May 2023
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      DOI: 10.1016/j.ccell.2023.04.016

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    sciencedirect.com/science/article/pii/S1535610823001423
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    Asymmetric cell division safeguards memory CD8 T cell development
    1
    1. scibot 13 May 2023
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      DOI: 10.1016/j.celrep.2023.112468

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    sciencedirect.com/science/article/pii/S2211124723004795
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    cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity
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    1. scibot 11 May 2023
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      DOI: 10.1016/j.immuni.2023.04.005

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    sciencedirect.com/science/article/pii/S1074761323001735
  41. Mar 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation
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    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112250

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    sciencedirect.com/science/article/pii/S2211124723002619
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    Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions
    1
    1. scibot 02 Mar 2023
      RRID:AB_11149115

      DOI: 10.1016/j.celrep.2023.112153

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    sciencedirect.com/science/article/pii/S221112472300164X
  44. Jan 2023
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
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    1. scibot 07 Jan 2023
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      DOI: 10.1158/2159-8290.CD-21-0003

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    ncbi.nlm.nih.gov/pmc/articles/PMC9401506/
  46. Nov 2022
  47. www.sciencedirect.com www.sciencedirect.com
    CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation
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    1. scibot 16 Nov 2022
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      DOI: 10.1016/j.celrep.2022.111639

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    sciencedirect.com/science/article/pii/S2211124722015108
  48. www.sciencedirect.com www.sciencedirect.com
    Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy
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    1. scibot 16 Nov 2022
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      DOI: 10.1016/j.celrep.2022.111647

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    sciencedirect.com/science/article/pii/S2211124722015182
  49. Aug 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation
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    1. scibot 23 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111193

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    sciencedirect.com/science/article/pii/S2211124722010105
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    Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis
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      DOI: 10.1016/j.chom.2022.07.015

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    sciencedirect.com/science/article/pii/S1931312822003614
  52. Jun 2022
  53. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
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    1. scibot 24 Jun 2022
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      DOI: 10.1016/j.ccell.2022.06.001

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    sciencedirect.com/science/article/pii/S1535610822002318
  54. May 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1
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      DOI: 10.1016/j.isci.2022.104278

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    sciencedirect.com/science/article/pii/S258900422200548X
  56. Apr 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
    1
    1. scibot 13 Apr 2022
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      DOI: 10.1016/j.immuni.2022.03.013

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    sciencedirect.com/science/article/pii/S1074761322001364
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    Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
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    sciencedirect.com/science/article/pii/S1074761322001315
  59. Mar 2022
  60. www.sciencedirect.com www.sciencedirect.com
    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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    1. scibot 18 Mar 2022
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      DOI: 10.1016/j.cmet.2022.02.009

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    sciencedirect.com/science/article/pii/S1550413122000535
  61. Dec 2021
  62. www.sciencedirect.com www.sciencedirect.com
    Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential
    1
    1. scibot 01 Dec 2021
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      DOI: 10.1016/j.celrep.2021.110064

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    sciencedirect.com/science/article/pii/S2211124721015503
  63. Nov 2021
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function
    1
    1. scibot 05 Nov 2021
      RRID:AB_11149115

      DOI: 10.7554/eLife.67476

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    ncbi.nlm.nih.gov/pmc/articles/PMC8553335/
  65. Sep 2021
  66. www.sciencedirect.com www.sciencedirect.com
    A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells
    1
    1. scibot 22 Sep 2021
      RRID:AB_11149115

      DOI: 10.1016/j.immuni.2021.08.029

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    sciencedirect.com/science/article/pii/S1074761321003630
  67. May 2021
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist
    1
    1. scibot 21 May 2021
      Anti-mouse CD3ε (145–2 c11) Armenian hamster monoclonal

      DOI: 10.7554/eLife.65777

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    ncbi.nlm.nih.gov/pmc/articles/PMC8131104/
  69. Apr 2021
  70. www.sciencedirect.com www.sciencedirect.com
    Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells
    1
    1. scibot 24 Apr 2021
      RRID:AB_11149115

      DOI: 10.1016/j.cell.2021.01.018

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    sciencedirect.com/science/article/pii/S0092867421000611
  71. www.sciencedirect.com www.sciencedirect.com
    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
    1
    1. scibot 15 Apr 2021
      RRID:AB_11149115

      DOI: 10.1016/j.celrep.2021.108966

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    sciencedirect.com/science/article/pii/S2211124721002801
  72. www.cell.com www.cell.com
    Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity
    1
    1. scibot 02 Apr 2021
      RRID:AB_11149115

      DOI: 10.1016/j.cmet.2021.03.002

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    cell.com/cell-metabolism/fulltext/S1550-4131(21)00109-1
  73. Mar 2021
  74. www.sciencedirect.com www.sciencedirect.com
    Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
    1
    1. scibot 10 Mar 2021
      RRID:AB_11149115

      DOI: 10.1016/j.celrep.2021.108831

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    sciencedirect.com/science/article/pii/S2211124721001455
  75. Feb 2021
  76. www.sciencedirect.com www.sciencedirect.com
    Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy
    1
    1. scibot 11 Feb 2021
      RRID:AB_11149115

      DOI: 10.1016/j.celrep.2021.108706

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    sciencedirect.com/science/article/pii/S221112472100019X
  77. Sep 2020
  78. www.sciencedirect.com www.sciencedirect.com
    Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection
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    1. scibot 23 Sep 2020
      RRID:AB_11149115

      DOI: 10.1016/j.celrep.2020.108078

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    sciencedirect.com/science/article/pii/S2211124720310639
  79. www.sciencedirect.com www.sciencedirect.com
    Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function
    1
    1. scibot 23 Sep 2020
      RRID:AB_11149115

      DOI: 10.1016/j.cmet.2020.03.004

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    sciencedirect.com/science/article/pii/S1550413120301194
  80. www.sciencedirect.com www.sciencedirect.com
    A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling
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    1. scibot 04 Sep 2020
      RRID:AB_11149115

      DOI: 10.1016/j.celrep.2020.03.030

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    sciencedirect.com/science/article/pii/S2211124720303442
  81. Jan 2020
  82. www.sciencedirect.com www.sciencedirect.com
    Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells
    1
    1. scibot 13 Jan 2020
      RRID:AB_11149115

      DOI: 10.1016/j.cell.2019.07.044

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    sciencedirect.com/science/article/pii/S009286741930844X
  83. www.sciencedirect.com www.sciencedirect.com
    TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases
    1
    1. scibot 13 Jan 2020
      RRID:AB_11149115

      DOI: 10.1016/j.celrep.2019.05.061

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    sciencedirect.com/science/article/pii/S2211124719306904
  84. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_11149115

      DOI: 10.1016/j.cels.2019.01.004

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    sciencedirect.com/science/article/pii/S2405471219300328
  85. Nov 2018
  86. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 05 Nov 2018
      RRID:AB_11149115

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    sciencedirect.com/science/article/pii/S2211124718310854
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells
    1
    1. scibot 05 Nov 2018
      RRID:AB_11149115

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC5728720/
  88. Nov 2017
  89. www.sciencedirect.com www.sciencedirect.com
    Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells
    1
    1. scibot 08 Nov 2017
      RRID:AB_11149115

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1074761317303151