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Jun 2026
aacrjournals.org aacrjournals.org

PI3Kα inhibitor and degrader inavolisib can co-opt FGFR2 to enhance responses in patients with PIK3CA-mutated solid tumors and in preclinical models

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  DOI: 10.1158/1078-0432.CCR-25-1459
  
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aacrjournals.org/clincancerres/article/32/1/56/771272/PI3K-Inhibitor-and-Degrader-Inavolisib-Can-Co-opt
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Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation

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  DOI: 10.1016/j.celrep.2026.117504
  
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sciencedirect.com/science/article/pii/S2211124726005826
Apr 2026
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Anticancer activity of RAS-GTP inhibition in cholangiocarcinoma

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.ccell.2026.03.020
  
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sciencedirect.com/science/article/pii/S1535610826001741
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Involvement of the FGF8/FGF receptor signaling pathway in the maintenance and progression of fusion-positive rhabdomyosarcoma

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1. scibot 25 Feb 2026
  
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  DOI: 10.1158/1535-7163.MCT-24-0328
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12928154/
Jan 2026
link.springer.com link.springer.com

FGFR1 and FGFR4 are essential regulators of muscle stem cell quiescence

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1. scibot 06 Jan 2026
  
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  DOI: 10.1186/s12964-025-02533-0
  
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link.springer.com/article/10.1186/s12964-025-02533-0
Dec 2025
www.nature.com www.nature.com

CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

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  DOI: 10.1038/s41523-025-00851-7
  
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  DOI: 10.1038/s41523-025-00851-7
  
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nature.com/articles/s41523-025-00851-7
Nov 2025
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Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116526
  
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sciencedirect.com/science/article/pii/S2211124725012975
Sep 2025
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Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.neuron.2025.08.005
  
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sciencedirect.com/science/article/pii/S0896627325005914
Aug 2025
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Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-0775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11790258/
Jul 2025
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Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.cell.2024.05.025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11246234/
May 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225007874-main-html.html

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112526
  
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52.53.155.43/c336c57443491cd4dc5ae0bf77fccdf6be4f7175/1-s2.0-S2589004225007874-main-html.html
Feb 2025
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Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization

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1. scibot 04 Feb 2025
  
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  DOI: 10.1007/s10456-024-09965-1
  
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link.springer.com/article/10.1007/s10456-024-09965-1
Feb 2024
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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

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1. scibot 06 Feb 2024
  
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  DOI: 10.1016/j.cmet.2024.01.005
  
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sciencedirect.com/science/article/pii/S1550413124000068
Jul 2023
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112868
  
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sciencedirect.com/science/article/pii/S2211124723008793
Jun 2023
52.53.155.43 52.53.155.43

Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer

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1. scibot 16 Jun 2023
  
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  DOI: 10.1021/acs.jmedchem.3c00150
  
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52.53.155.43/26aa5ba62138ec506c6f952066d20d6f92d1221c/acs.jmedchem.3c00150-html.html
Apr 2023
www.nature.com www.nature.com

Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer

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1. scibot 18 Apr 2023
  
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  DOI: 10.1038/s41416-023-02264-4
  
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nature.com/articles/s41416-023-02264-4
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells

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1. scibot 11 Feb 2023
  
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  DOI: 10.21037/tlcr-22-507
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9903082/
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DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1

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1. scibot 01 Feb 2023
  
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  DOI: 10.1158/2767-9764.crc-22-0013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9881645/
Dec 2022
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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111834
  
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sciencedirect.com/science/article/pii/S2211124722017260
Nov 2022
aacrjournals.org aacrjournals.org

DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1

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1. scibot 16 Nov 2022
  
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  DOI: 10.1158/2767-9764.CRC-22-0013
  
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aacrjournals.org/cancerrescommun/article/2/11/1388/710518/DDR2-Coordinates-EMT-and-Metabolic-Reprogramming
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes

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1. scibot 12 Oct 2022
  
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  DOI: 10.1158/2643-3230.BCD-21-0115
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9414116/
May 2022
www.researchsquare.com www.researchsquare.com

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  DOI: 10.21203/rs.3.rs-658360/v1
  
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researchsquare.com/
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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.devcel.2022.04.018
  
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sciencedirect.com/science/article/pii/S1534580722002866
Apr 2022
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Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells

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1. scibot 21 Apr 2022
  
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  DOI: 10.1016/j.chembiol.2022.03.010
  
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sciencedirect.com/science/article/pii/S2451945622001271
Nov 2021
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 23 Nov 2021
  
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  DOI: 10.1111/bph.15701
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15701
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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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  DOI: 10.1016/j.celrep.2021.109957
  
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sciencedirect.com/science/article/pii/S2211124721014340
Jul 2021
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Untitled document

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  DOI: 10.1016/j.celrep.2019.02.014
  
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sciencedirect.com/science/article/pii/S2211124719301767
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Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons

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  DOI: 10.1016/j.brainres.2018.06.017
  
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sciencedirect.com/science/article/pii/S0006899318303445
Jun 2021
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The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

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  DOI: 10.1016/j.ccell.2021.06.003
  
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sciencedirect.com/science/article/pii/S1535610821002865
Apr 2021
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The bone microenvironment invigorates metastatic seeds for further dissemination

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  DOI: 10.1016/j.cell.2021.03.011
  
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sciencedirect.com/science/article/pii/S0092867421002968
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The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells

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1. scibot 20 Apr 2021
  
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  DOI: 10.1016/j.devcel.2021.03.008
  
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sciencedirect.com/science/article/pii/S1534580721002057
Mar 2021
academic.oup.com academic.oup.com

FGF19 in the hindbrain lowers blood glucose and alters excitability of vagal motor neurons in hyperglycemic mice

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1. scibot 22 Mar 2021
  
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  DOI: 10.1210/endocr/bqab021
  
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academic.oup.com/endo/article/162/4/bqab021/6127285
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models

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1. scibot 27 Feb 2021
  
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  AB_11178519
  
  DOI: 10.1371/journal.pone.0231877
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7313537/
Sep 2020
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Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates

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Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

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FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice

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Jan 2020
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Tanycyte-like cells derived from mouse embryonic stem culture show hypothalamic neural stem/progenitor cell functions

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N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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Nov 2018
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