90 Matching Annotations
  1. Dec 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    1. scibot 13 Dec 2024
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      DOI: 10.1177/17588359241303302

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    pmc.ncbi.nlm.nih.gov/articles/PMC11632859/
  3. www.sciencedirect.com www.sciencedirect.com
    Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation
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    1. scibot 12 Dec 2024
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      DOI: 10.1016/j.devcel.2024.11.008

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    sciencedirect.com/science/article/pii/S1534580724006737
  4. Oct 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination
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    1. scibot 05 Oct 2024
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      DOI: 10.1016/j.isci.2024.110882

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    ncbi.nlm.nih.gov/pmc/articles/PMC11440251/
  6. Sep 2024
  7. link.springer.com link.springer.com
    TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus
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    1. scibot 27 Sep 2024
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      DOI: 10.1007/s12035-024-04504-x

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    link.springer.com/article/10.1007/s12035-024-04504-x
  8. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.cels.2019.03.009

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    sciencedirect.com/science/article/pii/S2405471219300791
  9. www.biorxiv.org www.biorxiv.org
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    1. scibot 15 Sep 2024
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      DOI: 10.1101/2024.09.05.611458

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    biorxiv.org/content/10.1101/2024.09.05.611458v1
  10. www.sciencedirect.com www.sciencedirect.com
    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
    1
    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S0092867424009048
  11. Aug 2024
  12. academic.oup.com academic.oup.com
    Senescent endometrial stromal cells transmit reactive oxygen species to the trophoblast-like cells and impair spreading of blastocyst-like spheroids
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1093/molehr/gaac039

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  13. Jul 2024
  14. www.cell.com www.cell.com
    A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
    1
    1. scibot 25 Jul 2024
      AB_11178658

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    cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00273-3
  15. Jun 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1158/1078-0432.CCR-23-3839

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    ncbi.nlm.nih.gov/pmc/articles/PMC11145169/
  17. May 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mecp2 fine-tunes quiescence exit by targeting nuclear receptors
    1
    1. scibot 17 May 2024
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      DOI: 10.7554/eLife.89912

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    ncbi.nlm.nih.gov/pmc/articles/PMC11095939/
  19. www.science.org www.science.org
    CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication
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    1. scibot 03 May 2024
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      DOI: 10.1126/science.adi2421

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    science.org/doi/10.1126/science.adi2421
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
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    1. scibot 02 May 2024
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      DOI: 10.1158/1078-0432.CCR-22-2854

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060649/
  21. Apr 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    1. scibot 20 Apr 2024
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      DOI: 10.1016/j.devcel.2024.03.032

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    sciencedirect.com/science/article/pii/S1534580724002004
  23. Mar 2024
  24. www.sciencedirect.com www.sciencedirect.com
    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001291
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
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    1. scibot 06 Mar 2024
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      DOI: 10.1158/2159-8290.CD-23-0954

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    ncbi.nlm.nih.gov/pmc/articles/PMC10905675/
  26. Feb 2024
  27. 52.53.155.43 52.53.155.43
    cd-23-0954-html.html
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    1. scibot 27 Feb 2024
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      DOI: 10.1158/2159-8290.cd-23-0954

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    52.53.155.43/aaf525c30ae01b53e260240fad732783dfb4bbac/cd-23-0954-html.html
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    Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
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    1. scibot 21 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001384
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
    1
    1. scibot 01 Feb 2024
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      DOI: 10.1038/s41698-024-00496-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  30. Dec 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
    1
    1. scibot 29 Dec 2023
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      DOI: 10.1016/j.isci.2023.108659

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    sciencedirect.com/science/article/pii/S2589004223027360
  32. Nov 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.chembiol.2023.10.011

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    sciencedirect.com/science/article/abs/pii/S2451945623003720
  34. www.cell.com www.cell.com
    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.020

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    cell.com/molecular-cell/fulltext/S1097-2765(23)00857-2
  35. www.sciencedirect.com www.sciencedirect.com
    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.molcel.2023.10.017

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  36. www.sciencedirect.com www.sciencedirect.com
    p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113486

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    sciencedirect.com/science/article/pii/S2211124723014985
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antitumor effects of PRMT5 inhibition in sarcomas
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    1. scibot 09 Nov 2023
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      DOI: 10.1158/2767-9764.CRC-23-0239

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    ncbi.nlm.nih.gov/pmc/articles/PMC10621483/
  38. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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    1. scibot 03 Nov 2023
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      DOI: 10.1158/2159-8290.CD-23-0669

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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  39. Oct 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  41. www.sciencedirect.com www.sciencedirect.com
    Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection
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    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113181

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    sciencedirect.com/science/article/pii/S2211124723011932
  42. Aug 2023
  43. www.sciencedirect.com www.sciencedirect.com
    FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth
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      DOI: 10.1016/j.celrep.2023.112886

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    sciencedirect.com/science/article/pii/S2211124723008975
  44. Jul 2023
  45. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
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    1. scibot 21 Jul 2023
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      DOI: 10.1111/bph.16193

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    52.53.155.43/51180316abfac9593501c4c683749a3ad6cad477/British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
  46. www.sciencedirect.com www.sciencedirect.com
    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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      DOI: 10.1016/j.xcrm.2023.101120

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    sciencedirect.com/science/article/pii/S2666379123002483
  47. Jun 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
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      DOI: 10.1016/j.cell.2023.05.013

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    sciencedirect.com/science/article/pii/S0092867423005329
  49. May 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Protocol to determine the subcellular localization of protein interactions in murine keratinocytes
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      DOI: 10.1016/j.xpro.2023.102309

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    sciencedirect.com/science/article/pii/S2666166723002769
  51. Mar 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction
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      DOI: 10.1016/j.celrep.2023.112252

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    sciencedirect.com/science/article/pii/S2211124723002632
  53. www.sciencedirect.com www.sciencedirect.com
    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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      DOI: 10.1016/j.celrep.2023.112188

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    sciencedirect.com/science/article/pii/S2211124723001997
  54. Jan 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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      DOI: 10.1016/j.celrep.2023.112031

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    sciencedirect.com/science/article/pii/S2211124723000426
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    The human placenta shapes the phenotype of decidual macrophages
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    sciencedirect.com/science/article/pii/S2211124722018812
  57. Dec 2022
  58. www.sciencedirect.com www.sciencedirect.com
    p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1
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      DOI: 10.1016/j.celrep.2022.111810

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  59. Oct 2022
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  62. Sep 2022
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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  64. Aug 2022
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    Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression
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  67. May 2022
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    Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells
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  69. Apr 2022
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  71. Mar 2022
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    The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia
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    CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities
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  74. Jan 2022
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    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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  76. Dec 2021
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    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
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    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
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  79. Nov 2021
  80. 52.53.155.43 52.53.155.43
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  81. Oct 2021
  82. mct.aacrjournals.org mct.aacrjournals.org
    Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
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  83. Sep 2021
  84. www.sciencedirect.com www.sciencedirect.com
    Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
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    Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells
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  86. Aug 2021
  87. www.nature.com www.nature.com
    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
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  88. www.sciencedirect.com www.sciencedirect.com
    Molecular control of cell density-mediated exit to quiescence
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  89. europepmc.org europepmc.org
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  91. Jul 2021
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    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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      P-Rb

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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors
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    CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells
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      8516T

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  96. May 2021
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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    Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer
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    Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control
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    Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells
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    Deciphering the signaling network of breast cancer improves drug sensitivity prediction
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  102. Apr 2021
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
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    Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors
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  106. Dec 2020
  107. www.cell.com www.cell.com
    Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation
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  109. Sep 2020
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single cell analysis reveals multiple requirements for zinc in the mammalian cell cycle
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    Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging
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    GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma
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      anti-pRb

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  113. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors
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      p-RB1-S807/811

      DOI: 10.1158/1078-0432.CCR-19-2706

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  114. Jan 2020
  115. www.sciencedirect.com www.sciencedirect.com
    Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements
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      RRID:AB_11178658

      DOI: 10.1016/j.cell.2019.08.013

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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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      RRID:AB_11178658

      DOI: 10.1016/j.cels.2019.11.001

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    Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1
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      RRID:AB_11178658

      DOI: 10.1016/j.molcel.2019.08.020

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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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    1. scibot 13 Jan 2020
      RRID:AB_11178658

      DOI: 10.1016/j.cell.2019.05.041

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    sciencedirect.com/science/article/pii/S0092867419306129
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    1. scibot 13 Jan 2020
      RRID:AB_11178658

      DOI: 10.1016/j.chembiol.2019.02.015

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    sciencedirect.com/science/article/pii/S2451945619300704
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      RRID:AB_11178658

      DOI: 10.1016/j.molcel.2019.01.004

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      RRID:AB_11178658

      DOI: 10.1016/j.molcel.2019.04.021

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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      RRID:AB_11178658

      DOI: 10.7554/eLife.40856

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      RRID:AB_11178658

      DOI: 10.1016/j.molcel.2019.03.020

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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    1. scibot 12 Jan 2020
      RRID:AB_11178658

      DOI: 10.1016/j.ebiom.2019.03.027

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    sciencedirect.com/science/article/pii/S2352396419301677
  125. Nov 2018
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    Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
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      RRID:AB_11178658

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    sciencedirect.com/science/article/pii/S1535610817305093