81 Matching Annotations
  1. Jun 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
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    1. scibot 07 Jun 2024
      RRID:AB_11178658

      DOI: 10.1158/1078-0432.CCR-23-3839

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    ncbi.nlm.nih.gov/pmc/articles/PMC11145169/
  3. May 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mecp2 fine-tunes quiescence exit by targeting nuclear receptors
    1
    1. scibot 17 May 2024
      RRID:AB_11178658

      DOI: 10.7554/eLife.89912

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    ncbi.nlm.nih.gov/pmc/articles/PMC11095939/
  5. www.science.org www.science.org
    CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication
    1
    1. scibot 03 May 2024
      RRID:AB_11178658

      DOI: 10.1126/science.adi2421

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    science.org/doi/10.1126/science.adi2421
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
    1
    1. scibot 02 May 2024
      RRID:AB_11178658

      DOI: 10.1158/1078-0432.CCR-22-2854

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060649/
  7. Apr 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
    1
    1. scibot 20 Apr 2024
      RRID:AB_11178658

      DOI: 10.1016/j.devcel.2024.03.032

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    sciencedirect.com/science/article/pii/S1534580724002004
  9. Mar 2024
  10. www.sciencedirect.com www.sciencedirect.com
    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
      RRID:AB_11178658

      DOI: 10.1016/j.molcel.2024.02.010

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    2. scibot 08 Mar 2024
      RRID:AB_11178658

      DOI: 10.1016/j.molcel.2024.02.010

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    sciencedirect.com/science/article/pii/S1097276524001291
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
    1
    1. scibot 06 Mar 2024
      RRID:AB_11178658

      DOI: 10.1158/2159-8290.CD-23-0954

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    ncbi.nlm.nih.gov/pmc/articles/PMC10905675/
  12. Feb 2024
  13. 52.53.155.43 52.53.155.43
    cd-23-0954-html.html
    2
    1. scibot 27 Feb 2024
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      DOI: 10.1158/2159-8290.cd-23-0954

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    2. scibot 27 Feb 2024
      RRID:AB_11178658

      DOI: 10.1158/2159-8290.cd-23-0954

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    52.53.155.43/aaf525c30ae01b53e260240fad732783dfb4bbac/cd-23-0954-html.html
  14. www.sciencedirect.com www.sciencedirect.com
    Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113810

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    sciencedirect.com/science/article/pii/S2211124724001384
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
    1
    1. scibot 01 Feb 2024
      RRID:AB_11178658

      DOI: 10.1038/s41698-024-00496-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  16. Dec 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
    1
    1. scibot 29 Dec 2023
      RRID:AB_11178658

      DOI: 10.1016/j.isci.2023.108659

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    sciencedirect.com/science/article/pii/S2589004223027360
  18. Nov 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
    1
    1. scibot 28 Nov 2023
      RRID:AB_11178658

      DOI: 10.1016/j.chembiol.2023.10.011

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    sciencedirect.com/science/article/abs/pii/S2451945623003720
  20. www.cell.com www.cell.com
    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
    1
    1. scibot 28 Nov 2023
      RRID:AB_11178658

      DOI: 10.1016/j.molcel.2023.10.020

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    cell.com/molecular-cell/fulltext/S1097-2765(23)00857-2
  21. www.sciencedirect.com www.sciencedirect.com
    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
    1
    1. scibot 28 Nov 2023
      RRID:AB_11178658

      DOI: 10.1016/j.molcel.2023.10.017

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    sciencedirect.com/science/article/pii/S1097276523008547
  22. www.sciencedirect.com www.sciencedirect.com
    p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP
    1
    1. scibot 28 Nov 2023
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2023.113486

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    sciencedirect.com/science/article/pii/S2211124723014985
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antitumor effects of PRMT5 inhibition in sarcomas
    1
    1. scibot 09 Nov 2023
      RRID:AB_11178658

      DOI: 10.1158/2767-9764.CRC-23-0239

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    ncbi.nlm.nih.gov/pmc/articles/PMC10621483/
  24. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
    1
    1. scibot 03 Nov 2023
      RRID:AB_11178658

      DOI: 10.1158/2159-8290.CD-23-0669

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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
  25. Oct 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  27. www.sciencedirect.com www.sciencedirect.com
    Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection
    1
    1. scibot 13 Oct 2023
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2023.113181

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    sciencedirect.com/science/article/pii/S2211124723011932
  28. Aug 2023
  29. www.sciencedirect.com www.sciencedirect.com
    FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth
    1
    1. scibot 03 Aug 2023
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2023.112886

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    sciencedirect.com/science/article/pii/S2211124723008975
  30. Jul 2023
  31. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
    1
    1. scibot 21 Jul 2023
      RRID:AB_11178658

      DOI: 10.1111/bph.16193

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    52.53.155.43/51180316abfac9593501c4c683749a3ad6cad477/British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
  32. www.sciencedirect.com www.sciencedirect.com
    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
    1
    1. scibot 14 Jul 2023
      RRID:AB_11178658

      DOI: 10.1016/j.xcrm.2023.101120

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    sciencedirect.com/science/article/pii/S2666379123002483
  33. Jun 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
    1
    1. scibot 02 Jun 2023
      RRID:AB_11178658

      DOI: 10.1016/j.cell.2023.05.013

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    sciencedirect.com/science/article/pii/S0092867423005329
  35. May 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Protocol to determine the subcellular localization of protein interactions in murine keratinocytes
    1
    1. scibot 18 May 2023
      RRID:AB_11178658

      DOI: 10.1016/j.xpro.2023.102309

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    sciencedirect.com/science/article/pii/S2666166723002769
  37. Mar 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction
    1
    1. scibot 16 Mar 2023
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2023.112252

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    sciencedirect.com/science/article/pii/S2211124723002632
  39. www.sciencedirect.com www.sciencedirect.com
    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
    1
    1. scibot 02 Mar 2023
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2023.112188

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    sciencedirect.com/science/article/pii/S2211124723001997
  40. Jan 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
    1
    1. scibot 24 Jan 2023
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2023.112031

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    sciencedirect.com/science/article/pii/S2211124723000426
  42. www.sciencedirect.com www.sciencedirect.com
    The human placenta shapes the phenotype of decidual macrophages
    1
    1. scibot 12 Jan 2023
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2022.111977

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    sciencedirect.com/science/article/pii/S2211124722018812
  43. Dec 2022
  44. www.sciencedirect.com www.sciencedirect.com
    p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1
    1
    1. scibot 18 Dec 2022
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2022.111810

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    sciencedirect.com/science/article/pii/S2211124722016989
  45. Oct 2022
  46. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
    1
    1. scibot 28 Oct 2022
      RRID:AB_11178658

      DOI: 10.1016/j.chembiol.2022.10.006

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    sciencedirect.com/science/article/pii/S2451945622003609
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human cutaneous interfollicular melanocytes differentiate temporarily under genotoxic stress
    1
    1. scibot 26 Oct 2022
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      DOI: 10.1016/j.isci.2022.105238

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    ncbi.nlm.nih.gov/pmc/articles/PMC9579029/
  48. Sep 2022
  49. www.sciencedirect.com www.sciencedirect.com
    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
    1
    1. scibot 21 Sep 2022
      RRID:AB_11178658

      DOI: 10.1016/j.celrep.2022.111396

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    sciencedirect.com/science/article/pii/S2211124722012335
  50. Aug 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression
    1
    1. scibot 23 Aug 2022
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      DOI: 10.1016/j.molcel.2022.07.014

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    sciencedirect.com/science/article/pii/S1097276522007109
  52. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Alterations of serine racemase expression determine proliferation and differentiation of neuroblastoma cells
    1
    1. scibot 18 Aug 2022
      RRID:AB_11178658

      DOI: 10.1096/fj.202200394RRR

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202200394RRR
  53. May 2022
  54. academic.oup.com academic.oup.com
    Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells
    1
    1. scibot 26 May 2022
      RRID:AB_11178658

      DOI: 10.1093/humrep/deac112

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    academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deac112/6590738
  55. Apr 2022
  56. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
    1
    1. scibot 05 Apr 2022
      RRID:AB_11178658

      DOI: 10.1111/bph.15763

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15763
  57. Mar 2022
  58. www.sciencedirect.com www.sciencedirect.com
    The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia
    1
    1. scibot 02 Mar 2022
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      DOI: 10.1016/j.isci.2022.103881

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    sciencedirect.com/science/article/pii/S2589004222001511
  59. www.sciencedirect.com www.sciencedirect.com
    CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities
    1
    1. scibot 02 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110448

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  60. Jan 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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  62. Dec 2021
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
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  65. Nov 2021
  66. 52.53.155.43 52.53.155.43
    ajpheart.00125.2021-html.html
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  67. Oct 2021
  68. mct.aacrjournals.org mct.aacrjournals.org
    Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
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  69. Sep 2021
  70. www.sciencedirect.com www.sciencedirect.com
    Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
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    Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells
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  72. Aug 2021
  73. www.nature.com www.nature.com
    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
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    Molecular control of cell density-mediated exit to quiescence
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  75. europepmc.org europepmc.org
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  77. Jul 2021
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    RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors
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    CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells
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  82. May 2021
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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    Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control
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    Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells
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    Deciphering the signaling network of breast cancer improves drug sensitivity prediction
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  88. Apr 2021
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
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    Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors
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  92. Dec 2020
  93. www.cell.com www.cell.com
    Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation
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  95. Sep 2020
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single cell analysis reveals multiple requirements for zinc in the mammalian cell cycle
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    Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging
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    GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma
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      anti-pRb

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  99. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors
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      p-RB1-S807/811

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  100. Jan 2020
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    Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements
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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1
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    Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
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    MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer
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    sciencedirect.com/science/article/pii/S2352396419301677
  111. Nov 2018
  112. www.sciencedirect.com www.sciencedirect.com
    Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
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    1. scibot 05 Nov 2018
      RRID:AB_11178658

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      (Cell Signaling Technology Cat# 8516S, RRID:AB_11178658)

      SciCrunch record: RRID:AB_11178658

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_11178658
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    sciencedirect.com/science/article/pii/S1535610817305093