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Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells

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1. scibot 09 Sep 2025
  
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  DOI: 10.1016/j.xcrm.2025.102328
  
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sciencedirect.com/science/article/pii/S266637912500401X
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3525
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314509/
Jul 2025
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RFX2-BNIP3 axis-driven adaptive mitophagy promotes resistance to ACK1-targeted therapy in non-small cell lung cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1038/s41388-025-03502-0
  
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nature.com/articles/s41388-025-03502-0
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Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.07.002
  
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sciencedirect.com/science/article/pii/S1535610825002739
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

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1. scibot 02 Jul 2025
  
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  DOI: 10.1126/sciadv.adu8422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12189954/
Jun 2025
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Cardiomyocyte-derived YOD1 promotes pathological cardiac hypertrophy by deubiquitinating and stabilizing STAT3

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1. scibot 28 Jun 2025
  
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  DOI: 10.1126/sciadv.adu8422
  
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science.org/doi/10.1126/sciadv.adu8422
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Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.cmet.2025.05.013
  
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sciencedirect.com/science/article/pii/S1550413125002694
May 2025
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Foxp3 confers long-term efficacy of chimeric antigen receptor-T cells via metabolic reprogramming

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.cmet.2025.04.008
  
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sciencedirect.com/science/article/pii/S1550413125002189
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Integrase enables synthetic intercellular logic via bacterial conjugation

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.cels.2025.101268
  
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sciencedirect.com/science/article/pii/S2405471225001012
Apr 2025
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THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis

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1. scibot 15 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115555
  
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sciencedirect.com/science/article/pii/S2211124725003262
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LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115489
  
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sciencedirect.com/science/article/pii/S2211124725002608
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Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115487
  
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sciencedirect.com/science/article/pii/S221112472500258X
Mar 2025
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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

1
1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.024
  
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sciencedirect.com/science/article/pii/S1097276525001868
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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.devcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1534580725001212
Feb 2025
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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

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1. scibot 04 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115250
  
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sciencedirect.com/science/article/pii/S221112472500021X
Jan 2025
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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.molcel.2024.12.025
  
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sciencedirect.com/science/article/pii/S1097276524010669
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Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.cmet.2024.11.012
  
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sciencedirect.com/science/article/pii/S1550413124004807
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Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9

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1. scibot 07 Jan 2025
  
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  DOI: 10.1016/j.devcel.2024.12.013
  
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sciencedirect.com/science/article/pii/S1534580724007342
Dec 2024
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Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.008
  
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sciencedirect.com/science/article/pii/S1074761324005235
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Probiotics-sensing mechanism in neurons that initiates gut mitochondrial surveillance for pathogen defense

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115021
  
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sciencedirect.com/science/article/pii/S221112472401372X
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis

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1. scibot 05 Oct 2024
  
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  DOI: 10.1016/j.isci.2024.110911
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440250/
Sep 2024
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HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma

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1. scibot 27 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114756
  
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Aug 2024
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A broad-spectrum multiepitope vaccine against seasonal influenza A and B viruses in mice

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.ebiom.2024.105269
  
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sciencedirect.com/science/article/pii/S2352396424003050
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ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.jare.2024.07.021
  
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sciencedirect.com/science/article/pii/S2090123224003060
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Ca<sup>2+</sup> entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips

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1. scibot 02 Aug 2024
  
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  DOI: 10.1091/mbc.E21-10-0491
  
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molbiolcell.org/doi/10.1091/mbc.E21-10-0491
academic.oup.com academic.oup.com

Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6

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1. scibot 02 Aug 2024
  
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  DOI: 10.1093/cercor/bhab242
  
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academic.oup.com/cercor/advance-article-abstract/doi/10.1093/cercor/bhab242/6338536
May 2024
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Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.cmet.2024.04.018
  
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sciencedirect.com/science/article/pii/S1550413124001384
Apr 2024
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Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects

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1. scibot 10 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109544
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10995871/
Mar 2024
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ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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  DOI: 10.1016/j.cell.2024.02.013
  
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sciencedirect.com/science/article/pii/S009286742400179X
Feb 2024
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ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation

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1. scibot 22 Feb 2024
  
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  DOI: 10.1016/j.devcel.2024.01.026
  
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Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

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1. scibot 03 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108858
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10830871/
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A SUMO E3 ligase promotes long non-coding RNA transcription to regulate small RNA-directed DNA elimination

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1. scibot 02 Feb 2024
  
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  DOI: 10.7554/eLife.95337
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10830130/
Jan 2024
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Suppression of Drosophila antifungal immunity by a parasite effector via blocking GNBP3 and GNBP-like 3, the dual receptors for β-glucans

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1. scibot 11 Jan 2024
  
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  RRID:AB_11232599
  
  DOI: 10.1016/j.celrep.2023.113642
  
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sciencedirect.com/science/article/pii/S2211124723016534
Dec 2023
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FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression

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E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

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MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

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The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy

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Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5

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The PtdIns3P phosphatase MtMP promotes symbiotic nitrogen fixation via mitophagy in Medicago truncatula

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Inhibition of FNDC1 suppresses gastric cancer progression by interfering with Gβγ-VEGFR2 complex formation

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C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair

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PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ

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Integrated regulation of tubulin tyrosination and microtubule stability by human α-tubulin isotypes

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Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

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VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

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Cofilin promotes tau pathology in Alzheimer’s disease

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Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling

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Sensing of a spore surface protein by a Drosophila chemosensory protein induces behavioral defense against fungal parasitic infections

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circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells

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Oct 2022
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Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas

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Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis

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An anillin-CIN85-SEPT9 complex promotes intercellular bridge maturation required for successful cytokinesis

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Ubiquitination of phosphatidylethanolamine in organellar membranes

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Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips

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  DOI: 10.1091/mbc.E21-10-0491
  
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Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma

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BPS Publications

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A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation

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LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

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  DOI: 10.1016/j.cell.2019.07.021
  
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Female-to-male sex reversal in orange-spotted grouper (Epinephelus coioides) caused by overexpressing of Amh in vivo

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  AB_11 232 599
  
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Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction

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ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis

1
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Sep 2020
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Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor

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lncRNA Sensing of a Viral Suppressor of RNAi Activates Non-canonical Innate Immune Signaling in Drosophila

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LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

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  DOI: 10.1016/j.immuni.2019.11.015
  
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Untitled document

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Female-to-male sex reversal in orange-spotted grouper (Epinephelus coioides) caused by overexpressing of Amh in vivo

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  DOI: 10.7554/eLife.42426
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6361614/
Nov 2018
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GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion

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Structural Insights into the pH-Dependent Conformational Change and Collagen Recognition of the Human Mannose Receptor

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SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport

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